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MITF melanocyte inducing transcription factor [ Gallus gallus (chicken) ]

Gene ID: 395886, updated on 3-Apr-2024

Summary

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Official Symbol
MITFprovided by CGNC
Official Full Name
melanocyte inducing transcription factorprovided by CGNC
Primary source
CGNC:49531
See related
Ensembl:ENSGALG00010022062
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
CMI9
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 12
Exon count:
15
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 12 NC_052543.1 (15667695..15755531)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 12 NC_052584.1 (15701339..15789098)

Chromosome 12 - NC_052543.1Genomic Context describing neighboring genes Neighboring gene FERM domain containing 4B Neighboring gene uncharacterized LOC121106660 Neighboring gene uncharacterized LOC427595 Neighboring gene 2-epi-5-epi-valiolone synthase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mitf functions as an in ovo regulator for cell differentiation and proliferation during development of the chick RPE. Tsukiji N, et al. Dev Biol, 2009 Feb 15. PMID 19100253
  2. Role of Mitf in differentiation and transdifferentiation of chicken pigmented epithelial cell. Mochii M, et al. Dev Biol, 1998 Jan 1. PMID 9466887
  3. FOXD3 regulates the lineage switch between neural crest-derived glial cells and pigment cells by repressing MITF through a non-canonical mechanism. Thomas AJ, et al. Development, 2009 Jun. PMID 19403660, Free PMC Article
  4. Retina regeneration in the chick embryo is not induced by spontaneous Mitf downregulation but requires FGF/FGFR/MEK/Erk dependent upregulation of Pax6. Spence JR, et al. Mol Vis, 2007 Jan 24. PMID 17277739, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. FOXD3 controls the lineage choice between neural/glial and pigment cells by repressing MITF during the early phase of neural crest migration.
    Title: FOXD3 regulates the lineage switch between neural crest-derived glial cells and pigment cells by repressing MITF through a non-canonical mechanism.
  2. These results demonstrate for the first time "in vivo" that Mitf uniquely regulates both differentiation and cell proliferation in the developing retinal pigment epithelium.
    Title: Mitf functions as an in ovo regulator for cell differentiation and proliferation during development of the chick RPE.
  3. Mitf is spontaneously downregulated after removal of retina. Downregulation is not accompanied by Pax6 upregulation. FGF2 stimulated Pax6 upregulation is required for transdifferentiation of retinal pigment epithelium.
    Title: Retina regeneration in the chick embryo is not induced by spontaneous Mitf downregulation but requires FGF/FGFR/MEK/Erk dependent upregulation of Pax6.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein dimerization activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in melanocyte differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
microphthalmia-associated transcription factor
Names
melanogenesis associated transcription factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_205029.1 → NP_990360.1  microphthalmia-associated transcription factor

    See identical proteins and their annotated locations for NP_990360.1

    Status: PROVISIONAL

    Source sequence(s)
    D88363
    UniProtKB/TrEMBL
    A0A1D5NVH0, A0A8V0ZNC5, O73871
    Conserved Domains (4) summary
    cd00083
    Location:251 → 311
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
    pfam11851
    Location:339 → 464
    DUF3371; Domain of unknown function (DUF3371)
    pfam15951
    Location:4 → 142
    MITF_TFEB_C_3_N; MITF/TFEB/TFEC/TFE3 N-terminus
    cl21462
    Location:307 → 342
    bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052543.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    15667695..15755531
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015292966.4 → XP_015148452.2  microphthalmia-associated transcription factor isoform X1

    UniProtKB/TrEMBL
    A0A8V0ZNC5
    Conserved Domains (4) summary
    cd00083
    Location:308 → 368
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
    pfam11851
    Location:396 → 521
    DUF3371; Domain of unknown function (DUF3371)
    pfam15951
    Location:55 → 193
    MITF_TFEB_C_3_N; MITF/TFEB/TFEC/TFE3 N-terminus
    cl21462
    Location:364 → 399
    bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain

  2. XM_015292967.4 → XP_015148453.2  microphthalmia-associated transcription factor isoform X2

    UniProtKB/TrEMBL
    A0A8V0ZNC5
    Conserved Domains (4) summary
    cd00083
    Location:302 → 362
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
    pfam11851
    Location:390 → 515
    DUF3371; Domain of unknown function (DUF3371)
    pfam15951
    Location:55 → 193
    MITF_TFEB_C_3_N; MITF/TFEB/TFEC/TFE3 N-terminus
    cl21462
    Location:358 → 393
    bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain

  3. XM_015292968.4 → XP_015148454.2  microphthalmia-associated transcription factor isoform X3

    UniProtKB/TrEMBL
    A0A8V0ZNC5
    Conserved Domains (4) summary
    cd00083
    Location:280 → 340
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
    pfam11851
    Location:368 → 493
    DUF3371; Domain of unknown function (DUF3371)
    pfam15951
    Location:55 → 198
    MITF_TFEB_C_3_N; MITF/TFEB/TFEC/TFE3 N-terminus
    cl21462
    Location:336 → 371
    bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain

  4. XM_015292970.4 → XP_015148456.2  microphthalmia-associated transcription factor isoform X5

    UniProtKB/TrEMBL
    A0A3Q2U6P0, A0A8V0ZNC5
    Related
    ENSGALP00010032326.1, ENSGALT00010053663.1
    Conserved Domains (4) summary
    cd00083
    Location:274 → 334
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
    pfam11851
    Location:362 → 487
    DUF3371; Domain of unknown function (DUF3371)
    pfam15951
    Location:55 → 198
    MITF_TFEB_C_3_N; MITF/TFEB/TFEC/TFE3 N-terminus
    cl21462
    Location:330 → 365
    bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain

  5. XM_046899817.1 → XP_046755773.1  microphthalmia-associated transcription factor isoform X6

  6. XM_015292969.4 → XP_015148455.1  microphthalmia-associated transcription factor isoform X4

    UniProtKB/TrEMBL
    A0A8V0ZNC5
    Conserved Domains (4) summary
    cd00083
    Location:276 → 336
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
    pfam11851
    Location:364 → 489
    DUF3371; Domain of unknown function (DUF3371)
    pfam15951
    Location:23 → 161
    MITF_TFEB_C_3_N; MITF/TFEB/TFEC/TFE3 N-terminus
    cl21462
    Location:332 → 367
    bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain

  7. XM_040646098.2 → XP_040502032.1  microphthalmia-associated transcription factor isoform X6

    UniProtKB/TrEMBL
    A0A8V0ZNC5
    Conserved Domains (3) summary
    cd18926
    Location:248 → 351
    bHLHzip_MITF; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in microphthalmia-associated transcription factor (MITF) and similar proteins
    pfam11851
    Location:345 → 470
    DUF3371; Domain of unknown function (DUF3371)
    pfam15951
    Location:4 → 142
    MITF_TFEB_C_3_N; MITF/TFEB/TFEC/TFE3 N-terminus

  8. XM_046899816.1 → XP_046755772.1  microphthalmia-associated transcription factor isoform X6

  9. XM_046899818.1 → XP_046755774.1  microphthalmia-associated transcription factor isoform X6

  10. XM_015292972.4 → XP_015148458.1  microphthalmia-associated transcription factor isoform X7

    UniProtKB/TrEMBL
    A0A8V0ZNC0
    Conserved Domains (4) summary
    cd00083
    Location:202 → 262
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
    pfam11851
    Location:290 → 415
    DUF3371; Domain of unknown function (DUF3371)
    pfam15951
    Location:11 → 87
    MITF_TFEB_C_3_N; MITF/TFEB/TFEC/TFE3 N-terminus
    cl21462
    Location:258 → 293
    bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain

  11. XM_015292973.3 → XP_015148459.1  microphthalmia-associated transcription factor isoform X8

    UniProtKB/TrEMBL
    A0A8V0ZNC0, B6E281
    Conserved Domains (4) summary
    cd00083
    Location:196 → 256
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
    pfam11851
    Location:284 → 409
    DUF3371; Domain of unknown function (DUF3371)
    pfam15951
    Location:11 → 87
    MITF_TFEB_C_3_N; MITF/TFEB/TFEC/TFE3 N-terminus
    cl21462
    Location:252 → 287
    bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain

  12. XM_015292974.3 → XP_015148460.1  microphthalmia-associated transcription factor isoform X9

    UniProtKB/TrEMBL
    A0A8V0ZNC0, Q9IAU0
    Related
    ENSGALP00010032317.1, ENSGALT00010053653.1
    Conserved Domains (4) summary
    cd00083
    Location:168 → 228
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
    pfam11851
    Location:256 → 381
    DUF3371; Domain of unknown function (DUF3371)
    pfam15951
    Location:11 → 92
    MITF_TFEB_C_3_N; MITF/TFEB/TFEC/TFE3 N-terminus
    cl21462
    Location:224 → 259
    bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052584.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    15701339..15789098
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046926059.1 → XP_046782015.1  microphthalmia-associated transcription factor isoform X1

  2. XM_046926060.1 → XP_046782016.1  microphthalmia-associated transcription factor isoform X2

  3. XM_046926061.1 → XP_046782017.1  microphthalmia-associated transcription factor isoform X3

  4. XM_046926063.1 → XP_046782019.1  microphthalmia-associated transcription factor isoform X5

    UniProtKB/TrEMBL
    A0A3Q2U6P0

  5. XM_046926065.1 → XP_046782021.1  microphthalmia-associated transcription factor isoform X6

  6. XM_046926062.1 → XP_046782018.1  microphthalmia-associated transcription factor isoform X4

  7. XM_046926064.1 → XP_046782020.1  microphthalmia-associated transcription factor isoform X6

  8. XM_046926067.1 → XP_046782023.1  microphthalmia-associated transcription factor isoform X6

  9. XM_046926066.1 → XP_046782022.1  microphthalmia-associated transcription factor isoform X6

  10. XM_046926068.1 → XP_046782024.1  microphthalmia-associated transcription factor isoform X7

  11. XM_046926069.1 → XP_046782025.1  microphthalmia-associated transcription factor isoform X8

    UniProtKB/TrEMBL
    B6E281

  12. XM_046926070.1 → XP_046782026.1  microphthalmia-associated transcription factor isoform X9

    UniProtKB/TrEMBL
    Q9IAU0
Nucleotide Protein Strain
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