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RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) [ Gallus gallus (chicken) ]

Gene ID: 395871, updated on 3-Apr-2024

Summary

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Symbol
RAC1provided by CGNC
Full Name
ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)provided by CGNC
Primary source
CGNC:49523
See related
Ensembl:ENSGALG00010019145
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
CRAC1A
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 14
Exon count:
7
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 14 NC_052545.1 (8829045..8842913, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 14 NC_052586.1 (8825962..8839830, complement)

Chromosome 14 - NC_052545.1Genomic Context describing neighboring genes Neighboring gene KDEL endoplasmic reticulum protein retention receptor 2 Neighboring gene diacylglycerol lipase beta Neighboring gene cytohesin 3 Neighboring gene uncharacterized LOC124417201 Neighboring gene small integral membrane protein 10 like 1 Neighboring gene uncharacterized LOC121106843

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Rac1/p21-activated kinase pathway controls retinoblastoma protein phosphorylation and E2F transcription factor activation in B lymphocytes. Zaldua N, et al. FEBS J, 2016 Feb. PMID 26663827
  2. Lipid raft-targeted Akt promotes axonal branching and growth cone expansion via mTOR and Rac1, respectively. Grider MH, et al. J Neurosci Res, 2009 Nov 1. PMID 19530170, Free PMC Article
  3. Differential expression of distinct members of Rho family GTP-binding proteins during neuronal development: identification of Rac1B, a new neural-specific member of the family. Malosio ML, et al. J Neurosci, 1997 Sep 1. PMID 9254684, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. By evaluating the effect of Rac1, the RB-E2F complex activation dependency on PAK and PKCepsilon activities was established, being independent of both actin cytoskeleton reorganization and Ras activity.
    Title: Rac1/p21-activated kinase pathway controls retinoblastoma protein phosphorylation and E2F transcription factor activation in B lymphocytes.
  2. Akt activity can regulate growth cone expansion via localized Rac1 signaling and regulate axonal branching and soma size via activation of mTOR.
    Title: Lipid raft-targeted Akt promotes axonal branching and growth cone expansion via mTOR and Rac1, respectively.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein kinase binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in actin filament organization IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cortical cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in establishment or maintenance of cell polarity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in motor neuron axon guidance IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of actin cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of cell shape IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in small GTPase-mediated signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cell cortex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in dendritic spine IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
ras-related C3 botulinum toxin substrate 1
Names
GTPase cRac1A
Rac family small GTPase 1
NP_990348.1
XP_015149624.1
XP_046783248.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_205017.2 → NP_990348.1  ras-related C3 botulinum toxin substrate 1

    See identical proteins and their annotated locations for NP_990348.1

    Status: PROVISIONAL

    Source sequence(s)
    JAENSK010000257
    UniProtKB/TrEMBL
    A0A8V1AIF5, F1N8D9, Q6LC82
    Conserved Domains (1) summary
    cd01871
    Location:3 → 176
    Rac1_like; Ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)-like consists of Rac1, Rac2 and Rac3

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052545.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    8829045..8842913 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015294138.4 → XP_015149624.1  ras-related C3 botulinum toxin substrate 1 isoform X1

    UniProtKB/TrEMBL
    A0A8V0Z8U4, A0A8V1AIF5
    Related
    ENSGALP00010027595.1, ENSGALT00010046332.1
    Conserved Domains (1) summary
    cd01871
    Location:3 → 195
    Rac1_like; Ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)-like consists of Rac1, Rac2 and Rac3

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052586.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    8825962..8839830 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046927292.1 → XP_046783248.1  ras-related C3 botulinum toxin substrate 1 isoform X1

    UniProtKB/TrEMBL
    A0A8V0Z8U4
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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