LEF1 lymphoid enhancer binding factor 1 [Gallus gallus (chicken)] - Gene

Summary

Symbol: LEF1provided by CGNC
Full Name: lymphoid enhancer binding factor 1provided by CGNC
Primary source: CGNC:7997
See related: Ensembl:ENSGALG00010005587
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as: LEF-1
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 4

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	4	NC_052535.1 (37449291..37503977)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	4	NC_052576.1 (37402546..37457178)

Chromosome 4 - NC_052535.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Downregulation of PITX2 and LEF1 genes may interfere with ventral body wall formation in Cd chick model causing omphalocele by disrupting somite myogenesis.
Title: Altered PITX2 and LEF1 gene expression in the cadmium-induced omphalocele in the chick model.
Wnt/Lef1 signaling regulates epaxial myogenesis via Pitx2.
Title: Wnt/Lef1 signaling acts via Pitx2 to regulate somite myogenesis.
Knockout of LEF1 in the developing peripheral eye lead to partial loss of the iris and ciliary body hypoplasia.
Title: Wnt2b/beta-catenin-mediated canonical Wnt signaling determines the peripheral fates of the chick eye.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in canonical Wnt signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
part_of beta-catenin-TCF complex	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: lymphoid enhancer-binding factor 1

Names: lymphiod enhancer binding factor 1; transcription factor LEF-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001398055.1 → NP_001384984.1 lymphoid enhancer-binding factor 1 isoform 1

Status: VALIDATED

Source sequence(s)

JAENSK010000073

UniProtKB/TrEMBL

A0A3Q3B1W2

Related

ENSGALP00010007939.1, ENSGALT00010013390.1

Conserved Domains (2) summary

cd01388
Location:296 → 367

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

pfam08347
Location:1 → 211

CTNNB1_binding; N-terminal CTNNB1 binding
NM_001398056.1 → NP_001384985.1 lymphoid enhancer-binding factor 1 isoform 2

Status: VALIDATED

Source sequence(s)

JAENSK010000073

UniProtKB/TrEMBL

A0A8V0XV79

Related

ENSGALP00010007934.1, ENSGALT00010013383.1

Conserved Domains (2) summary

cd01388
Location:296 → 367

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

pfam08347
Location:1 → 211

CTNNB1_binding; N-terminal CTNNB1 binding
NM_001398057.1 → NP_001384986.1 lymphoid enhancer-binding factor 1 isoform 3

Status: VALIDATED

Source sequence(s)

JAENSK010000073

UniProtKB/TrEMBL

A0A8V0XSL5

Related

ENSGALP00010007942.1, ENSGALT00010013396.1

Conserved Domains (2) summary

cd01388
Location:268 → 339

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

pfam08347
Location:1 → 211

CTNNB1_binding; N-terminal CTNNB1 binding
NM_001398058.1 → NP_001384987.1 lymphoid enhancer-binding factor 1 isoform 5

Status: VALIDATED

Source sequence(s)

JAENSK010000073

Related

ENSGALP00010007927.1, ENSGALT00010013374.1
NM_205013.3 → NP_990344.1 lymphoid enhancer-binding factor 1 isoform 4

See identical proteins and their annotated locations for NP_990344.1

Status: VALIDATED

Source sequence(s)

JAENSK010000073

UniProtKB/TrEMBL

A0A8V0XMK8, O93345

Related

ENSGALP00010007932.1, ENSGALT00010013381.1

Conserved Domains (2) summary

cd01388
Location:268 → 339

SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...

pfam08347
Location:1 → 211

CTNNB1_binding; N-terminal CTNNB1 binding