ID2 inhibitor of DNA binding 2, HLH protein [Gallus gallus (chicken)] - Gene

Summary

Symbol: ID2provided by CGNC
Full Name: inhibitor of DNA binding 2, HLH proteinprovided by CGNC
Primary source: CGNC:12279
See related: Ensembl:ENSGALG00010003117
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 3

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	3	NC_052534.1 (95549855..95551981)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	3	NC_052575.1 (95351007..95353141)

Chromosome 3 - NC_052534.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Gene-silencing experiments indicate that Id2 is one of the factors limiting the profibrogenic influence of BMPs in the developing digits.
Title: Ligand- and stage-dependent divergent functions of BMP signaling in the differentiation of embryonic skeletogenic progenitors in vitro.
Increased bone morphogenetic protein signaling induces expression of Id1, Id2, and Id3 along with the inhibition of atonal homolog 1 (Atoh1).
Title: Id gene regulation and function in the prosensory domains of the chicken inner ear: a link between Bmp signaling and Atoh1.
Data show that the Expression of Id2 both in vivo and in vitro was up-regulated in BMP-gain-of-function.
Title: Expression of Id2 in the developing limb is associated with zones of active BMP signaling and marks the regions of growth and differentiation of the developing digits.
These results indicate that Id proteins participate in NSC maintenance through sustaining Hes1 expression in early embryos.
Title: Id sustains Hes1 expression to inhibit precocious neurogenesis by releasing negative autoregulation of Hes1.
the presence of neural crest is required for normal Id2 expression in chick heart development
Title: Cardiac neural crest ablation alters Id2 gene expression in the developing heart.
Id2 expression in somites requires positive signalling from not only axial structures and lateral plate mesoderm but also surface ectoderm
Title: Dynamic Id2 expression in the medial and lateral domains of avian dermamyotome.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info	PubMed
enables transcription regulator activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in circadian regulation of gene expression	IEA Inferred from Electronic Annotation more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: DNA-binding protein inhibitor ID-2

Names: inhibitor of DNA binding 2, dominant negative helix-loop-helix protein; transcriptional regulator Id2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_205002.2 → NP_990333.1 DNA-binding protein inhibitor ID-2

See identical proteins and their annotated locations for NP_990333.1

Status: PROVISIONAL

Source sequence(s)

JAENSK010000066

UniProtKB/TrEMBL

F1NSW7, O73933

Related

ENSGALP00010004369.1, ENSGALT00010007268.1

Conserved Domains (1) summary

cd19692
Location:18 → 83

bHLH_dnHLH_ID2; basic helix-loop-helix (bHLH) domain found in DNA-binding protein inhibitor ID2 and similar proteins