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PXN paxillin [ Gallus gallus (chicken) ]

Gene ID: 395832, updated on 3-Apr-2024

Summary

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Official Symbol
PXNprovided by CGNC
Official Full Name
paxillinprovided by CGNC
Primary source
CGNC:5477
See related
Ensembl:ENSGALG00010021649
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
TGFB1I1
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 15
Exon count:
22
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 15 NC_052546.1 (9399104..9441327)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 15 NC_052587.1 (9398287..9440499)

Chromosome 15 - NC_052546.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC121111828 Neighboring gene phospholipase A2, major isoenzyme-like Neighboring gene U4 spliceosomal RNA Neighboring gene U4 spliceosomal RNA Neighboring gene sirtuin 4 Neighboring gene ribosomal protein lateral stalk subunit P0 Neighboring gene GCN1, eIF2 alpha kinase activator homolog Neighboring gene uncharacterized LOC121106864

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Phosphorylation of paxillin LD4 destabilizes helix formation and inhibits binding to focal adhesion kinase. Bertolucci CM, et al. Biochemistry, 2008 Jan 15. PMID 18092823, Free PMC Article
  2. Characterization of tyrosine phosphorylation of paxillin in vitro by focal adhesion kinase. Bellis SL, et al. J Biol Chem, 1995 Jul 21. PMID 7615549
  3. Structural and functional insights into the interaction between the Cas family scaffolding protein p130Cas and the focal adhesion-associated protein paxillin. Zhang C, et al. J Biol Chem, 2017 Nov 3. PMID 28860193, Free PMC Article
  4. Structural and mechanistic insights into the interaction between Pyk2 and paxillin LD motifs. Vanarotti MS, et al. J Mol Biol, 2014 Dec 12. PMID 25174335, Free PMC Article
  5. Force fluctuations within focal adhesions mediate ECM-rigidity sensing to guide directed cell migration. Plotnikov SV, et al. Cell, 2012 Dec 21. PMID 23260139, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Paxillin S273 Phosphorylation Regulates Adhesion Dynamics and Cell Migration through a Common Protein Complex with PAK1 and betaPIX.
    Title: Paxillin S273 Phosphorylation Regulates Adhesion Dynamics and Cell Migration through a Common Protein Complex with PAK1 and βPIX.
  2. Data suggest that the first LD motif (LD1; leucine-rich motif) of paxillin binds to the CCHD (C-terminal region of Cas family homology domain) of p130Cas/Bcar1 (in a 1:1 stoichiometry with Kd approximately 4.2 uM); p130Cas/Bcar1 CCHD is stabilized by forming complex with paxillin LD1; these studies utilized chicken paxillin and mouse p130Cas/Bcar1. (p130Cas/Bcar1 = breast cancer anti-estrogen resistance protein 1)
    Title: Structural and functional insights into the interaction between the Cas family scaffolding protein p130Cas and the focal adhesion-associated protein paxillin.
  3. Data indicate that chicken paxillin leucine-aspartate LD2 and LD4 motifs preferentially dock at the helix 2/3 binding site of human Proline-rich tyrosine kinase 2 (Pyk2)-focal adhesion kinase (FAK).
    Title: Structural and mechanistic insights into the interaction between Pyk2 and paxillin LD motifs.
  4. Phosphorylation of paxillin LD4 results in a reduction of binding affinity to FAK.
    Title: Phosphorylation of paxillin LD4 destabilizes helix formation and inhibits binding to focal adhesion kinase.
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Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by RefSeq

Process Evidence Code Pubs
involved_in endothelial cell migration IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in substrate adhesion-dependent cell spreading IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in transforming growth factor beta receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
paxillin
Names
transforming growth factor beta 1 induced transcript 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_204984.2 → NP_990315.2  paxillin

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000260
    UniProtKB/Swiss-Prot
    P49024
    Related
    ENSGALP00010031647.1, ENSGALT00010052741.1
    Conserved Domains (4) summary
    cd09338
    Location:444 → 496
    LIM3_Paxillin_like; The third LIM domain of the paxillin like protein family
    cd09407
    Location:385 → 436
    LIM2_Paxillin; The second LIM domain of paxillin
    cd09411
    Location:503 → 554
    LIM4_Paxillin; The fourth LIM domain of Paxillin
    cd09336
    Location:326 → 378
    LIM1_Paxillin_like; The first LIM domain of the paxillin like protein family

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052546.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    9399104..9441327
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046901102.1 → XP_046757058.1  paxillin isoform X5

  2. XM_015275211.4 → XP_015130697.1  paxillin isoform X4

    UniProtKB/TrEMBL
    A0A8V0ZED7
    Conserved Domains (5) summary
    cd09338
    Location:1035 → 1087
    LIM3_Paxillin_like; The third LIM domain of the paxillin like protein family
    cd09407
    Location:976 → 1027
    LIM2_Paxillin; The second LIM domain of paxillin
    cd09411
    Location:1094 → 1145
    LIM4_Paxillin; The fourth LIM domain of Paxillin
    cd09336
    Location:917 → 969
    LIM1_Paxillin_like; The first LIM domain of the paxillin like protein family
    pfam03535
    Location:51 → 251
    Paxillin; Paxillin family

  3. XM_046901099.1 → XP_046757055.1  paxillin isoform X1

    UniProtKB/TrEMBL
    A0A8V0ZLQ2
    Related
    ENSGALP00010031652.1, ENSGALT00010052746.1

  4. XM_046901105.1 → XP_046757061.1  paxillin isoform X8

  5. XM_046901103.1 → XP_046757059.1  paxillin isoform X6

    UniProtKB/TrEMBL
    A0A8V0ZS82
    Related
    ENSGALP00010031645.1, ENSGALT00010052739.1

  6. XM_046901101.1 → XP_046757057.1  paxillin isoform X5

  7. XM_046901100.1 → XP_046757056.1  paxillin isoform X4

  8. XM_015275210.4 → XP_015130696.1  paxillin isoform X3

    UniProtKB/TrEMBL
    A0A8V0ZED7
    Conserved Domains (5) summary
    cd09338
    Location:1036 → 1088
    LIM3_Paxillin_like; The third LIM domain of the paxillin like protein family
    cd09407
    Location:977 → 1028
    LIM2_Paxillin; The second LIM domain of paxillin
    cd09411
    Location:1095 → 1146
    LIM4_Paxillin; The fourth LIM domain of Paxillin
    cd09336
    Location:918 → 970
    LIM1_Paxillin_like; The first LIM domain of the paxillin like protein family
    pfam03535
    Location:52 → 252
    Paxillin; Paxillin family

  9. XM_015275209.4 → XP_015130695.1  paxillin isoform X2

    UniProtKB/TrEMBL
    A0A8V0ZED7
    Conserved Domains (5) summary
    cd09338
    Location:1036 → 1088
    LIM3_Paxillin_like; The third LIM domain of the paxillin like protein family
    cd09407
    Location:977 → 1028
    LIM2_Paxillin; The second LIM domain of paxillin
    cd09411
    Location:1095 → 1146
    LIM4_Paxillin; The fourth LIM domain of Paxillin
    cd09336
    Location:918 → 970
    LIM1_Paxillin_like; The first LIM domain of the paxillin like protein family
    pfam03535
    Location:52 → 252
    Paxillin; Paxillin family

  10. XM_046901104.1 → XP_046757060.1  paxillin isoform X7

    UniProtKB/TrEMBL
    F1NB68
    Related
    ENSGALP00010031578.1, ENSGALT00010052668.1

  11. XM_046901106.1 → XP_046757062.1  paxillin isoform X9

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052587.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    9398287..9440499
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046928062.1 → XP_046784018.1  paxillin isoform X10

  2. XM_046928069.1 → XP_046784025.1  paxillin isoform X13

  3. XM_046928064.1 → XP_046784020.1  paxillin isoform X12

  4. XM_046928065.1 → XP_046784021.1  paxillin isoform X2

  5. XM_046928070.1 → XP_046784026.1  paxillin isoform X7

  6. XM_046928067.1 → XP_046784023.1  paxillin isoform X3

  7. XM_046928066.1 → XP_046784022.1  paxillin isoform X2

  8. XM_046928068.1 → XP_046784024.1  paxillin isoform X4

  9. XM_046928063.1 → XP_046784019.1  paxillin isoform X11

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P49024.1 GenPept UniProtKB/Swiss-Prot:P49024

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