DLL1 delta like canonical Notch ligand 1 [Gallus gallus (chicken)] - Gene

Summary

Symbol: DLL1provided by CGNC
Full Name: delta like canonical Notch ligand 1provided by CGNC
Primary source: CGNC:8494
See related: Ensembl:ENSGALG00010007927
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 3

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	3	NC_052534.1 (40510855..40522846)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	3	NC_052575.1 (40408750..40420747)

Chromosome 3 - NC_052534.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Notch ligand Dll1 promotes neuroepithelial differentiation by reducing Notch signaling through a Cis-inhibition mechanism.
Title: Mib1 prevents Notch Cis-inhibition to defer differentiation and preserve neuroepithelial integrity during neural delamination.
Dll1 functions primarily in trans to regulate hair cell production but also additional mechanisms operate downstream of lateral inhibition to eliminate patterning errors in the sensory epithelia of the inner ear.
Title: Delta-like 1 and lateral inhibition during hair cell formation in the chicken inner ear: evidence against cis-inhibition.
Dll1 and Dll4 and proneural notch bHLH genes have roles in chick retinal development
Title: Relationship between Delta-like and proneural bHLH genes during chick retinal development.
in cultured chick leg bud mesenchyme cells, TGF-beta 3 downregulates ADAM 10 & inhibits cell proliferation & subsequent precartilage condensation by inhibiting the ectodomain shedding of delta-1, & that this results in the activation of Notch signaling.
Title: Suppression of ADAM 10-induced Delta-1 shedding inhibits cell proliferation during the chondro-inhibitory action of TGF-beta3.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in Notch signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in cell communication	IEA Inferred from Electronic Annotation more info	PubMed
involved_in establishment or maintenance of epithelial cell apical/basal polarity	IEA Inferred from Electronic Annotation more info	PubMed
involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	IEA Inferred from Electronic Annotation more info	PubMed
involved_in multicellular organism development	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed
part_of protein-containing complex	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: delta-like protein 1

Names: C-Delta-1; delta-like 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001397475.1 → NP_001384404.1 delta-like protein 1 isoform 2 precursor

Status: VALIDATED

Source sequence(s)

JAENSK010000063

Conserved Domains (3) summary

smart00051
Location:166 → 228

DSL; delta serrate ligand

cd00054
Location:336 → 371

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

pfam07657
Location:24 → 98

MNNL; N-terminus of Notch ligand
NM_204973.3 → NP_990304.2 delta-like protein 1 isoform 1 precursor

Status: VALIDATED

Source sequence(s)

JAENSK010000063

UniProtKB/TrEMBL

Q90656

Related

ENSGALP00010010452.1, ENSGALT00010018902.1

Conserved Domains (3) summary

smart00051
Location:166 → 228

DSL; delta serrate ligand

cd00054
Location:336 → 371

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

pfam07657
Location:24 → 98

MNNL; N terminus of Notch ligand