IHH indian hedgehog [Gallus gallus (chicken)] - Gene

Summary

Symbol: IHHprovided by CGNC
Full Name: indian hedgehogprovided by CGNC
Primary source: CGNC:49486
See related: Ensembl:ENSGALG00010021505
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 7

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	7	NC_052538.1 (21924895..21933614)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	7	NC_052579.1 (21844180..21852910)

Chromosome 7 - NC_052538.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Based on these results, the Ihh signal is essential for balancing chicken chondrocyte proliferation and hypertrophy, and the regulatory function of PTHrP acts in an Ihh-dependent manner.
Title: The Ihh signal is essential for regulating proliferation and hypertrophy of cultured chicken chondrocytes.
Reduction of Ihh in chicken embryo hindlimbs reduced skeletal muscle mass similar to that seen in Ihh(-/-) mouse embryos
Title: Growth of limb muscle is dependent on skeletal-derived Indian hedgehog.
IHH and FGF8 maybe play different roles and act synergistically to promote chondrogenesis during digit primordia elongation.
Title: IHH and FGF8 coregulate elongation of digit primordia.
Indian hedgehog and syndecan-3 have roles in chondrocyte proliferation and limb skeletogenesis
Title: Indian hedgehog and syndecans-3 coregulate chondrocyte proliferation and function during chick limb skeletogenesis.
BMPs are integrated into the Ihh/PTHrP signaling loop, and a fine balance of BMP signaling is essential for normal chondrocyte maturation and skeletal development.
Title: ALK2 functions as a BMP type I receptor and induces Indian hedgehog in chondrocytes during skeletal development.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info	PubMed
enables patched binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in cell fate specification	IEA Inferred from Electronic Annotation more info	PubMed
involved_in cell-cell signaling	IEA Inferred from Electronic Annotation more info	PubMed
involved_in multicellular organism development	IEA Inferred from Electronic Annotation more info	PubMed
involved_in protein autoprocessing	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of gene expression	IEA Inferred from Electronic Annotation more info	PubMed
involved_in smoothened signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular space	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: indian hedgehog protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_204957.3 → NP_990288.1 indian hedgehog protein precursor

See identical proteins and their annotated locations for NP_990288.1

Status: VALIDATED

Source sequence(s)

JAENSK010000236

UniProtKB/Swiss-Prot

Q98938

Related

ENSGALP00010031145.1, ENSGALT00010052149.1

Conserved Domains (3) summary

cd00081
Location:199 → 344

Hint; Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein, ...

pfam01079
Location:188 → 394

Hint; Hint module

pfam01085
Location:40 → 185

HH_signal; Hedgehog amino-terminal signalling domain