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EZR ezrin [ Gallus gallus (chicken) ]

Gene ID: 395701, updated on 3-Apr-2024

Summary

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Official Symbol
EZRprovided by CGNC
Official Full Name
ezrinprovided by CGNC
Primary source
CGNC:10288
See related
Ensembl:ENSGALG00010005548
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
VIL2
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 3
Exon count:
13
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 3 NC_052534.1 (51794533..51831250, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 3 NC_052575.1 (51699653..51736400, complement)

Chromosome 3 - NC_052534.1Genomic Context describing neighboring genes Neighboring gene dynein light chain Tctex-type 1 Neighboring gene synaptotagmin like 3 Neighboring gene uncharacterized LOC107053008 Neighboring gene T-cell activation RhoGTPase activating protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Specific expression of ezrin, a cytoskeletal-membrane linker protein, in a subset of chick retinotectal and sensory projections. Takahashi M, et al. Eur J Neurosci, 1999 Feb. PMID 10051754
  2. Activation of ezrin/radixin/moesin mediates attractive growth cone guidance through regulation of growth cone actin and adhesion receptors. Marsick BM, et al. J Neurosci, 2012 Jan 4. PMID 22219290, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Ezrin/radixin/moesin proteins organize actin filaments in sensory neuron growth cones and are crucial for neurotrophin-induced remodeling of F-actin and redistribution of adhesion receptors.
    Title: Activation of ezrin/radixin/moesin mediates attractive growth cone guidance through regulation of growth cone actin and adhesion receptors.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables cell adhesion molecule binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in positive regulation of early endosome to late endosome transport IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of protein localization to early endosome IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of cell shape IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of organelle assembly IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in adherens junction IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in apical part of cell IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in filopodium IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in microvillus IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
ezrin
Names
villin 2 (ezrin)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_204885.2 → NP_990216.1  ezrin

    See identical proteins and their annotated locations for NP_990216.1

    Status: PROVISIONAL

    Source sequence(s)
    JAENSK010000063
    UniProtKB/TrEMBL
    A0A8V0XUY7, F1P3H9, Q9YGW6
    Related
    ENSGALP00010007851.1, ENSGALT00010013289.1
    Conserved Domains (6) summary
    smart00295
    Location:7 → 206
    B41; Band 4.1 homologues
    cd13194
    Location:200 → 296
    FERM_C_ERM; FERM domain C-lobe/F3 of the ERM family
    pfam00373
    Location:91 → 206
    FERM_M; FERM central domain
    pfam00769
    Location:338 → 585
    ERM; Ezrin/radixin/moesin family
    pfam09379
    Location:9 → 68
    FERM_N; FERM N-terminal domain
    cl21478
    Location:307 → 374
    ATP-synt_B; ATP synthase B/B' CF(0)

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052534.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    51794533..51831250 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015284013.4 → XP_015139499.1  ezrin isoform X2

    Conserved Domains (3) summary
    cd13194
    Location:64 → 160
    FERM_C_ERM; FERM domain C-lobe/F3 of the ERM family
    pfam00769
    Location:202 → 449
    ERM; Ezrin/radixin/moesin family
    cl09511
    Location:24 → 70
    FERM_B-lobe; FERM domain B-lobe

  2. XM_046938482.1 → XP_046794438.1  ezrin isoform X1

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052575.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    51699653..51736400 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046913077.1 → XP_046769033.1  ezrin isoform X2

  2. XM_046913076.1 → XP_046769032.1  ezrin isoform X1

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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