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RPE65 RPE65, retinoid isomerohydrolase [ Gallus gallus (chicken) ]

Gene ID: 395700, updated on 3-Apr-2024

Summary

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Symbol
RPE65provided by CGNC
Full Name
RPE65, retinoid isomerohydrolaseprovided by CGNC
Primary source
CGNC:8554
See related
Ensembl:ENSGALG00010023506
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 8
Exon count:
14
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 8 NC_052539.1 (28459714..28468361, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 8 NC_052580.1 (28471737..28480382, complement)

Chromosome 8 - NC_052539.1Genomic Context describing neighboring genes Neighboring gene wntless Wnt ligand secretion mediator Neighboring gene microRNA 6653 Neighboring gene methylcrotonoyl-Coenzyme A carboxylase 2-like Neighboring gene DEP domain containing 1 Neighboring gene leucine rich repeat containing 7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Binding to lipid membrane induces conformational changes in RPE65: implications for its isomerohydrolase activity. Nikolaeva O, et al. Biochem J, 2011 Jun 15. PMID 21446919
  2. Purified RPE65 shows isomerohydrolase activity after reassociation with a phospholipid membrane. Nikolaeva O, et al. FEBS J, 2009 Jun. PMID 19490105, Free PMC Article
  3. Rpe65 isomerase associates with membranes through an electrostatic interaction with acidic phospholipid headgroups. Yuan Q, et al. J Biol Chem, 2010 Jan 8. PMID 19892706, Free PMC Article
  4. RPE65 has an additional function as the lutein to meso-zeaxanthin isomerase in the vertebrate eye. Shyam R, et al. Proc Natl Acad Sci U S A, 2017 Oct 10. PMID 28874556, Free PMC Article
  5. Identification of key residues determining isomerohydrolase activity of human RPE65. Takahashi Y, et al. J Biol Chem, 2014 Sep 26. PMID 25112876, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. RPE65 undergoes conformational changes in secondary and tertiary structures upon binding with the phospholipid membrane. These conformational rearrangements facilitate restoration of a catalytically active state of RPE65.
    Title: Binding to lipid membrane induces conformational changes in RPE65: implications for its isomerohydrolase activity.
  2. Rpe65 isomerase associates with membranes through an electrostatic interaction with acidic phospholipid headgroups.
    Title: Rpe65 isomerase associates with membranes through an electrostatic interaction with acidic phospholipid headgroups.
  3. Results provide conclusive evidence that RPE65 is the isomerohydrolase of the visual cycle.
    Title: Purified RPE65 shows isomerohydrolase activity after reassociation with a phospholipid membrane.
  4. RPE65 from the cone-dominant chicken RPE possesses significantly higher specific retinol isomerohydrolase activity, when compared with RPE65 from rod-dominant species
    Title: RPE65 from cone-dominant chicken is a more efficient isomerohydrolase compared with that from rod-dominant species.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables beta-carotene 15,15'-dioxygenase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables retinol isomerase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in retinal metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in zeaxanthin biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
retinoid isomerohydrolase
Names
all-trans-retinyl-palmitate hydrolase
lutein isomerase
meso-zeaxanthin isomerase
retinal pigment epithelium-specific 65 kDa protein
retinal pigment epithelium-specific protein 65kDa
retinol isomerase
NP_990215.1
XP_015146455.1
XP_040560441.1
XP_040560442.1
XP_046778292.1
XP_046778293.1
XP_046778294.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_204884.2 → NP_990215.1  retinoid isomerohydrolase

    See identical proteins and their annotated locations for NP_990215.1

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000239
    UniProtKB/Swiss-Prot
    Q9YGX2
    UniProtKB/TrEMBL
    A0A8V0ZWQ7
    Related
    ENSGALP00010034815.1, ENSGALT00010057251.1
    Conserved Domains (1) summary
    pfam03055
    Location:21 → 530
    RPE65; Retinal pigment epithelial membrane protein

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052539.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    28459714..28468361 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015290969.4 → XP_015146455.1  retinoid isomerohydrolase isoform X3

    UniProtKB/TrEMBL
    A0A8V0ZWQ7
    Conserved Domains (1) summary
    pfam03055
    Location:20 → 561
    RPE65; Retinal pigment epithelial membrane protein

  2. XM_040704508.2 → XP_040560442.1  retinoid isomerohydrolase isoform X2

    UniProtKB/TrEMBL
    A0A8V0ZN36, A0A8V1A0V9
    Related
    ENSGALP00010034818.1, ENSGALT00010057256.1
    Conserved Domains (1) summary
    cl10080
    Location:258 → 707
    RPE65; Retinal pigment epithelial membrane protein

  3. XM_040704507.2 → XP_040560441.1  retinoid isomerohydrolase isoform X1

    UniProtKB/TrEMBL
    A0A8V0ZN36
    Conserved Domains (1) summary
    cl10080
    Location:258 → 738
    RPE65; Retinal pigment epithelial membrane protein

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052580.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    28471737..28480382 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046922338.1 → XP_046778294.1  retinoid isomerohydrolase isoform X3

  2. XM_046922337.1 → XP_046778293.1  retinoid isomerohydrolase isoform X2

    UniProtKB/TrEMBL
    A0A8V1A0V9

  3. XM_046922336.1 → XP_046778292.1  retinoid isomerohydrolase isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9YGX2.1 GenPept UniProtKB/Swiss-Prot:Q9YGX2

Gene LinkOut

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