U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

JAK1 Janus kinase 1 [ Gallus gallus (chicken) ]

Gene ID: 395681, updated on 11-Apr-2024

Summary

Go to the top of the page Help
Symbol
JAK1provided by CGNC
Full Name
Janus kinase 1provided by CGNC
Primary source
CGNC:8381
See related
Ensembl:ENSGALG00010024493
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
chromosome: 8
Exon count:
27
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 8 NC_052539.1 (27885691..27938586, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 8 NC_052580.1 (27898533..27951149, complement)

Chromosome 8 - NC_052539.1Genomic Context describing neighboring genes Neighboring gene cache domain containing 1 Neighboring gene ribonucleoprotein, PTB binding 2 Neighboring gene uncharacterized LOC101749837 Neighboring gene microRNA 101-2 Neighboring gene microRNA mir-12281

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Molecular cloning, expression and evolutionary analysis of the avian tyrosine kinase JAK1. Bartunek P, et al. Gene, 1999 Apr 16. PMID 10216250
  2. The fibroblast growth factor receptor FGFR-4 acts as a ligand dependent modulator of erythroid cell proliferation. Koritschoner NP, et al. Oncogene, 1999 Oct 21. PMID 10557077
  3. Full-length cDNAs from chicken bursal lymphocytes to facilitate gene function analysis. Caldwell RB, et al. Genome Biol, 2005. PMID 15642098, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables cytokine receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables non-membrane spanning protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell surface receptor signaling pathway via JAK-STAT IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cytokine-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in hemopoiesis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in tyrosine phosphorylation of STAT protein IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
tyrosine-protein kinase JAK1
Names
Janus kinase 1 (a protein tyrosine kinase)
tyrosine kinase JAK1
NP_990201.2
XP_015146451.1
XP_025008524.1
XP_046778289.1
XP_046778290.1
XP_046778291.1
XP_046800209.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_204870.2 → NP_990201.2  tyrosine-protein kinase JAK1

    Status: PROVISIONAL

    Source sequence(s)
    JAENSK010000239
    UniProtKB/TrEMBL
    F1NMJ9, Q9PWM9
    Related
    ENSGALP00010036502.1, ENSGALT00010059742.1
    Conserved Domains (6) summary
    cd05079
    Location:864 → 1147
    PTKc_Jak1_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 1
    cd05077
    Location:576 → 840
    PTK_Jak1_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 1
    pfam18377
    Location:147 → 277
    FERM_F2; FERM F2 acyl-CoA binding protein-like domain
    pfam18379
    Location:36 → 129
    FERM_F1; FERM F1 ubiquitin-like domain
    cl15255
    Location:420 → 520
    SH2; Src homology 2 (SH2) domain
    cl17171
    Location:282 → 420
    PH-like; Pleckstrin homology-like domain

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052539.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    27885691..27938586 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015290965.4 → XP_015146451.1  tyrosine-protein kinase JAK1 isoform X1

    UniProtKB/TrEMBL
    F1NMJ9, Q9PWM9
    Conserved Domains (6) summary
    cd05079
    Location:864 → 1147
    PTKc_Jak1_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 1
    cd05077
    Location:576 → 840
    PTK_Jak1_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 1
    pfam18377
    Location:147 → 277
    FERM_F2; FERM F2 acyl-CoA binding protein-like domain
    pfam18379
    Location:36 → 129
    FERM_F1; FERM F1 ubiquitin-like domain
    cl15255
    Location:420 → 520
    SH2; Src homology 2 (SH2) domain
    cl17171
    Location:282 → 420
    PH-like; Pleckstrin homology-like domain

  2. XM_046944253.1 → XP_046800209.1  tyrosine-protein kinase JAK1 isoform X1

    UniProtKB/TrEMBL
    F1NMJ9

  3. XM_025152756.3 → XP_025008524.1  tyrosine-protein kinase JAK1 isoform X1

    UniProtKB/TrEMBL
    F1NMJ9, Q9PWM9
    Conserved Domains (6) summary
    cd05079
    Location:864 → 1147
    PTKc_Jak1_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 1
    cd05077
    Location:576 → 840
    PTK_Jak1_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 1
    pfam18377
    Location:147 → 277
    FERM_F2; FERM F2 acyl-CoA binding protein-like domain
    pfam18379
    Location:36 → 129
    FERM_F1; FERM F1 ubiquitin-like domain
    cl15255
    Location:420 → 520
    SH2; Src homology 2 (SH2) domain
    cl17171
    Location:282 → 420
    PH-like; Pleckstrin homology-like domain

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052580.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    27898533..27951149 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046922333.1 → XP_046778289.1  tyrosine-protein kinase JAK1 isoform X1

    UniProtKB/TrEMBL
    F1NMJ9

  2. XM_046922335.1 → XP_046778291.1  tyrosine-protein kinase JAK1 isoform X1

    UniProtKB/TrEMBL
    F1NMJ9

  3. XM_046922334.1 → XP_046778290.1  tyrosine-protein kinase JAK1 isoform X1

    UniProtKB/TrEMBL
    F1NMJ9
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.