NOTCH1 notch 1 [Gallus gallus (chicken)] - Gene

Summary

Symbol: NOTCH1provided by CGNC
Full Name: notch 1provided by CGNC
Primary source: CGNC:49424
See related: Ensembl:ENSGALG00010028107
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 17

Exon count:: 36

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	17	NC_052548.1 (8415416..8451054)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	17	NC_052589.1 (7826632..7862049)

Chromosome 17 - NC_052548.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Temperature sensitivity of Notch signaling underlies species-specific developmental plasticity and robustness in amniote brains.
Title: Temperature sensitivity of Notch signaling underlies species-specific developmental plasticity and robustness in amniote brains.
Mib1 prevents Notch Cis-inhibition to defer differentiation and preserve neuroepithelial integrity during neural delamination.
Title: Mib1 prevents Notch Cis-inhibition to defer differentiation and preserve neuroepithelial integrity during neural delamination.
Cytoplasmic NOTCH and membrane-derived beta-catenin link cell fate choice to epithelial-mesenchymal transition during myogenesis.
Title: Cytoplasmic NOTCH and membrane-derived β-catenin link cell fate choice to epithelial-mesenchymal transition during myogenesis.
These results identify a novel mechanism acting downstream of muscle contraction, where YAP activates JAG2 expression in muscle fibers, which in turn regulates the pool of fetal muscle progenitors via NOTCH in a non-cell-autonomous manner.
Title: Muscle contraction is required to maintain the pool of muscle progenitors via YAP and NOTCH during fetal myogenesis.
These data identify Notch signalling as a novel modulator of Shh signalling that acts mechanistically via regulation of ciliary localisation of key components of its transduction machinery.
Title: A conserved role for Notch signaling in priming the cellular response to Shh through ciliary localisation of the key Shh transducer Smo.
These results identified the apical endfoot as the central site of active Notch signaling to securely prohibit inappropriate differentiation of neural progenitors.
Title: Cadherin-based adhesions in the apical endfoot are required for active Notch signaling to control neurogenesis in vertebrates.
Mib1 is a major component of the signal-sending cells required to provide Notch ligand activity for specifying neurons and glia in the spinal cord
Title: The E3 ligase Mind bomb-1 (Mib1) modulates Delta-Notch signaling to control neurogenesis and gliogenesis in the developing spinal cord.
report that a novel evolutionarily conserved cis-element in the second intron of the Notch1 locus plays an important role in regulating gene expression in interneuron progenitors
Title: A cis-element in the Notch1 locus is involved in the regulation of gene expression in interneuron progenitors.
Notch Signaling Is Not Required for Growth of Intersomitic Vessels in the Chick Embryo.
Title: Hedgehog regulates angiogenesis of intersegmental vessels through the VEGF signaling pathway.
A novel Notch reporter with multiple destabilisation elements provides a faithful read-out of endogenous Notch activity.
Title: A novel reporter of notch signalling indicates regulated and random Notch activation during vertebrate neurogenesis.

Submit: New GeneRIF Correction See all GeneRIFs (22)

General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables Notch binding	IEA Inferred from Electronic Annotation more info	PubMed
enables calcium ion binding	IEA Inferred from Electronic Annotation more info	PubMed
enables signaling receptor activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in Notch signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in multicellular organism development	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of developmental process	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: neurogenic locus notch homolog protein 1

Names: Notch homolog 1, translocation-associated

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001397796.1 → NP_001384725.1 neurogenic locus notch homolog protein 1 isoform 1 precursor

Status: VALIDATED

Source sequence(s)

JAENSK010000308

UniProtKB/TrEMBL

A0A3Q2ULK6

Related

ENSGALP00010041850.1, ENSGALT00010068107.1

Conserved Domains (11) summary

smart00004
Location:1485 → 1521

NL; Domain found in Notch and Lin-12

COG0666
Location:1931 → 2121

ANKYR; Ankyrin repeat [Signal transduction mechanisms]

cd00054
Location:945 → 981

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

sd00045
Location:1880 → 1925

ANK; ANK repeat [structural motif]

pfam00066
Location:1532 → 1561

Notch; LNR domain

pfam03154
Location:2086 → 2543

Atrophin-1; Atrophin-1 family

pfam06816
Location:1567 → 1621

NOD; NOTCH protein

pfam07684
Location:1672 → 1727

NODP; NOTCH protein

pfam11936
Location:2476 → 2536

DUF3454; Domain of unknown function (DUF3454)

pfam12796
Location:1932 → 2025

Ank_2; Ankyrin repeats (3 copies)

cd21702
Location:1719 → 1798

JMTM_Notch1; juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein 1 (Notch1) and similar proteins
NM_001397797.1 → NP_001384726.1 neurogenic locus notch homolog protein 1 isoform 2 precursor

Status: VALIDATED

Source sequence(s)

JAENSK010000308

Conserved Domains (11) summary

smart00004
Location:1439 → 1475

NL; Domain found in Notch and Lin-12

COG0666
Location:1885 → 2075

ANKYR; Ankyrin repeat [Signal transduction mechanisms]

cd00054
Location:945 → 981

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

sd00045
Location:1834 → 1879

ANK; ANK repeat [structural motif]

pfam00066
Location:1486 → 1515

Notch; LNR domain

pfam03154
Location:2040 → 2497

Atrophin-1; Atrophin-1 family

pfam06816
Location:1521 → 1575

NOD; NOTCH protein

pfam07684
Location:1626 → 1681

NODP; NOTCH protein

pfam11936
Location:2430 → 2490

DUF3454; Domain of unknown function (DUF3454)

pfam12796
Location:1886 → 1979

Ank_2; Ankyrin repeats (3 copies)

cd21702
Location:1673 → 1752

JMTM_Notch1; juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein 1 (Notch1) and similar proteins

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

NC_052548.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Range

8415416..8451054

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_046901649.1 → XP_046757605.1 neurogenic locus notch homolog protein 1 isoform X1

Related

ENSGALP00010041847.1, ENSGALT00010068104.1
XM_046901650.1 → XP_046757606.1 neurogenic locus notch homolog protein 1 isoform X1

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

NC_052589.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Range

7826632..7862049

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_046928731.1 → XP_046784687.1 neurogenic locus notch homolog protein 1 isoform X1
XM_046928732.1 → XP_046784688.1 neurogenic locus notch homolog protein 1 isoform X1

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001030295.1: Suppressed sequence

Description

NM_001030295.1: This RefSeq was removed because currently there is support for the transcript but not for the protein.