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NUMB NUMB, endocytic adaptor protein [ Gallus gallus (chicken) ]

Gene ID: 395639, updated on 3-Apr-2024

Summary

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Symbol
NUMBprovided by CGNC
Full Name
NUMB, endocytic adaptor proteinprovided by CGNC
Primary source
CGNC:49418
See related
Ensembl:ENSGALG00010020945
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 5
Exon count:
25
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 5 NC_052536.1 (25688341..25818698)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 5 NC_052577.1 (25655039..25785313)

Chromosome 5 - NC_052536.1Genomic Context describing neighboring genes Neighboring gene prostaglandin reductase 2 Neighboring gene ELM2 and Myb/SANT domain containing 1 Neighboring gene dynein axonemal light chain 1 Neighboring gene acyl-coenzyme A thioesterase 1 Neighboring gene acyl-coenzyme A thioesterase 6 Neighboring gene translation initiation factor IF-2-like Neighboring gene microRNA 6587 Neighboring gene ribosomal oxygenase 1 Neighboring gene papilin, proteoglycan like sulfated glycoprotein Neighboring gene uncharacterized LOC121111006 Neighboring gene translation initiation factor IF-2-like Neighboring gene presenilin 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Asymmetric localization of numb in the chick somite and the influence of myogenic signals. Holowacz T, et al. Dev Dyn, 2006 Mar. PMID 16425215, Free PMC Article
  2. Transitin, a nestin-like intermediate filament protein, mediates cortical localization and the lateral transport of Numb in mitotic avian neuroepithelial cells. Wakamatsu Y, et al. Development, 2007 Jul. PMID 17522158
  3. NUMB localizes in the basal cortex of mitotic avian neuroepithelial cells and modulates neuronal differentiation by binding to NOTCH-1. Wakamatsu Y, et al. Neuron, 1999 May. PMID 10402194
  4. Rbfox3-regulated alternative splicing of Numb promotes neuronal differentiation during development. Kim KK, et al. J Cell Biol, 2013 Feb 18. PMID 23420872, Free PMC Article
  5. Phosphorylation by Rho kinase regulates CRMP-2 activity in growth cones. Arimura N, et al. Mol Cell Biol, 2005 Nov. PMID 16260611, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Rbfox3-dependent Numb alternative splicing plays an important role in the progression of neuronal differentiation during vertebrate development.
    Title: Rbfox3-regulated alternative splicing of Numb promotes neuronal differentiation during development.
  2. transitin has important roles in determining the intracellular localization of Numb, which regulates neurogenesis in the developing nervous system of avian embryos
    Title: Transitin, a nestin-like intermediate filament protein, mediates cortical localization and the lateral transport of Numb in mitotic avian neuroepithelial cells.
  3. Numb protein is asymmetrically localized in a cortical crescent on the basal side of dividing cells in the dorsomedial lip of the dermomyotome and is subsequently uniformly distributed throughout differentiated myotomal cells.
    Title: Asymmetric localization of numb in the chick somite and the influence of myogenic signals.
  4. Rho kinase phosphorylates CRMP-2, and inactivates the ability of CRMP-2 to promote microtubule assembly and Numb-mediated endocytosis, during growth cone collapse
    Title: Phosphorylation by Rho kinase regulates CRMP-2 activity in growth cones.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables cadherin binding IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
protein numb homolog
Names
numb homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_204835.3 → NP_990166.3  protein numb homolog

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000214
    UniProtKB/TrEMBL
    A0A0D4WTY6, Q9PW30, T1P3Y7
    Conserved Domains (2) summary
    cd01268
    Location:23 → 157
    PTB_Numb; Numb Phosphotyrosine-binding (PTB) domain
    pfam06311
    Location:250 → 328
    NumbF; NUMB domain

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052536.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    25688341..25818698
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046941390.1 → XP_046797346.1  protein numb homolog isoform X1

    UniProtKB/TrEMBL
    A0A8V0ZF56

  2. XM_046941389.1 → XP_046797345.1  protein numb homolog isoform X1

    UniProtKB/TrEMBL
    A0A8V0ZF56

  3. XM_040700610.2 → XP_040556544.1  protein numb homolog isoform X6

    UniProtKB/TrEMBL
    A0A0D4WTY6, Q9PW30, T1P3Y7
    Conserved Domains (2) summary
    cd01268
    Location:23 → 157
    PTB_Numb; Numb Phosphotyrosine-binding (PTB) domain
    pfam06311
    Location:250 → 328
    NumbF; NUMB domain

  4. XM_046941392.1 → XP_046797348.1  protein numb homolog isoform X1

    UniProtKB/TrEMBL
    A0A8V0ZF56

  5. XM_040700596.2 → XP_040556530.1  protein numb homolog isoform X1

    UniProtKB/TrEMBL
    A0A8V0ZF56, T1P426
    Conserved Domains (1) summary
    cd01268
    Location:23 → 183
    PTB_Numb; Numb Phosphotyrosine-binding (PTB) domain

  6. XM_046941393.1 → XP_046797349.1  protein numb homolog isoform X1

    UniProtKB/TrEMBL
    A0A8V0ZF56

  7. XM_040700598.2 → XP_040556532.1  protein numb homolog isoform X1

    UniProtKB/TrEMBL
    A0A8V0ZF56, T1P426
    Conserved Domains (1) summary
    cd01268
    Location:23 → 183
    PTB_Numb; Numb Phosphotyrosine-binding (PTB) domain

  8. XM_015286935.4 → XP_015142421.2  protein numb homolog isoform X1

    UniProtKB/TrEMBL
    A0A8V0ZF56, T1P426
    Conserved Domains (1) summary
    cd01268
    Location:23 → 183
    PTB_Numb; Numb Phosphotyrosine-binding (PTB) domain

  9. XM_025150567.3 → XP_025006335.2  protein numb homolog isoform X1

    UniProtKB/TrEMBL
    A0A8V0ZF56, T1P426
    Conserved Domains (1) summary
    cd01268
    Location:23 → 183
    PTB_Numb; Numb Phosphotyrosine-binding (PTB) domain

  10. XM_046941399.1 → XP_046797355.1  protein numb homolog isoform X6

    UniProtKB/TrEMBL
    A0A0D4WTY6

  11. XM_046941397.1 → XP_046797353.1  protein numb homolog isoform X3

    UniProtKB/TrEMBL
    A0A8V0ZGD0

  12. XM_015286934.4 → XP_015142420.2  protein numb homolog isoform X1

    UniProtKB/TrEMBL
    A0A8V0ZF56, T1P426
    Related
    ENSGALP00010029895.1, ENSGALT00010050637.1
    Conserved Domains (1) summary
    cd01268
    Location:23 → 183
    PTB_Numb; Numb Phosphotyrosine-binding (PTB) domain

  13. XM_015286941.4 → XP_015142427.2  protein numb homolog isoform X4

    UniProtKB/TrEMBL
    A0A0D4WTI4, A0A8V0ZMI5
    Related
    ENSGALP00010029889.1, ENSGALT00010050626.1
    Conserved Domains (1) summary
    cd01268
    Location:23 → 183
    PTB_Numb; Numb Phosphotyrosine-binding (PTB) domain

  14. XM_015286938.4 → XP_015142424.2  protein numb homolog isoform X2

    UniProtKB/TrEMBL
    T1P426
    Conserved Domains (1) summary
    cd01268
    Location:23 → 168
    PTB_Numb; Numb Phosphotyrosine-binding (PTB) domain

  15. XM_015286942.4 → XP_015142428.2  protein numb homolog isoform X5

    UniProtKB/TrEMBL
    A0A0D4WTI4
    Conserved Domains (1) summary
    cd01268
    Location:23 → 168
    PTB_Numb; Numb Phosphotyrosine-binding (PTB) domain

  16. XM_015286939.4 → XP_015142425.2  protein numb homolog isoform X3

    UniProtKB/TrEMBL
    A0A8V0ZGD0, T1P426
    Related
    ENSGALP00010029887.1, ENSGALT00010050623.1
    Conserved Domains (1) summary
    cd01268
    Location:23 → 157
    PTB_Numb; Numb Phosphotyrosine-binding (PTB) domain

  17. XM_015286936.4 → XP_015142422.2  protein numb homolog isoform X1

    UniProtKB/TrEMBL
    A0A8V0ZF56, T1P426
    Conserved Domains (1) summary
    cd01268
    Location:23 → 183
    PTB_Numb; Numb Phosphotyrosine-binding (PTB) domain

  18. XM_040700600.2 → XP_040556534.1  protein numb homolog isoform X2

    UniProtKB/TrEMBL
    T1P426
    Conserved Domains (1) summary
    cd01268
    Location:23 → 168
    PTB_Numb; Numb Phosphotyrosine-binding (PTB) domain

  19. XM_040700608.2 → XP_040556542.1  protein numb homolog isoform X5

    UniProtKB/TrEMBL
    A0A0D4WTI4
    Conserved Domains (1) summary
    cd01268
    Location:23 → 168
    PTB_Numb; Numb Phosphotyrosine-binding (PTB) domain

  20. XM_015286940.4 → XP_015142426.2  protein numb homolog isoform X3

    UniProtKB/TrEMBL
    A0A8V0ZGD0, T1P426
    Related
    ENSGALP00010029891.1, ENSGALT00010050632.1
    Conserved Domains (1) summary
    cd01268
    Location:23 → 157
    PTB_Numb; Numb Phosphotyrosine-binding (PTB) domain

  21. XM_040700612.2 → XP_040556546.1  protein numb homolog isoform X6

    UniProtKB/TrEMBL
    A0A0D4WTY6, Q9PW30, T1P3Y7
    Conserved Domains (2) summary
    cd01268
    Location:23 → 157
    PTB_Numb; Numb Phosphotyrosine-binding (PTB) domain
    pfam06311
    Location:250 → 328
    NumbF; NUMB domain

  22. XM_046941391.1 → XP_046797347.1  protein numb homolog isoform X1

    UniProtKB/TrEMBL
    A0A8V0ZF56

  23. XM_015286937.4 → XP_015142423.2  protein numb homolog isoform X1

    UniProtKB/TrEMBL
    A0A8V0ZF56, T1P426
    Conserved Domains (1) summary
    cd01268
    Location:23 → 183
    PTB_Numb; Numb Phosphotyrosine-binding (PTB) domain

  24. XM_046941396.1 → XP_046797352.1  protein numb homolog isoform X3

    UniProtKB/TrEMBL
    A0A8V0ZGD0

  25. XM_046941398.1 → XP_046797354.1  protein numb homolog isoform X6

    UniProtKB/TrEMBL
    A0A0D4WTY6

  26. XM_025150568.3 → XP_025006336.2  protein numb homolog isoform X1

    UniProtKB/TrEMBL
    A0A8V0ZF56, T1P426
    Conserved Domains (1) summary
    cd01268
    Location:23 → 183
    PTB_Numb; Numb Phosphotyrosine-binding (PTB) domain

  27. XM_046941394.1 → XP_046797350.1  protein numb homolog isoform X1

    UniProtKB/TrEMBL
    A0A8V0ZF56

  28. XM_046941395.1 → XP_046797351.1  protein numb homolog isoform X1

    UniProtKB/TrEMBL
    A0A8V0ZF56

  29. XM_040700606.2 → XP_040556540.1  protein numb homolog isoform X3

    UniProtKB/TrEMBL
    A0A8V0ZGD0, T1P426
    Conserved Domains (1) summary
    cd01268
    Location:23 → 157
    PTB_Numb; Numb Phosphotyrosine-binding (PTB) domain

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052577.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    25655039..25785313
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046917724.1 → XP_046773680.1  protein numb homolog isoform X1

  2. XM_046917723.1 → XP_046773679.1  protein numb homolog isoform X1

  3. XM_046917745.1 → XP_046773701.1  protein numb homolog isoform X6

  4. XM_046917729.1 → XP_046773685.1  protein numb homolog isoform X1

  5. XM_046917726.1 → XP_046773682.1  protein numb homolog isoform X1

  6. XM_046917731.1 → XP_046773687.1  protein numb homolog isoform X1

  7. XM_046917730.1 → XP_046773686.1  protein numb homolog isoform X1

  8. XM_046917725.1 → XP_046773681.1  protein numb homolog isoform X1

  9. XM_046917733.1 → XP_046773689.1  protein numb homolog isoform X1

  10. XM_046917748.1 → XP_046773704.1  protein numb homolog isoform X6

  11. XM_046917740.1 → XP_046773696.1  protein numb homolog isoform X3

  12. XM_046917721.1 → XP_046773677.1  protein numb homolog isoform X1

  13. XM_046917742.1 → XP_046773698.1  protein numb homolog isoform X4

  14. XM_046917735.1 → XP_046773691.1  protein numb homolog isoform X2

  15. XM_046917743.1 → XP_046773699.1  protein numb homolog isoform X5

  16. XM_046917737.1 → XP_046773693.1  protein numb homolog isoform X3

  17. XM_046917722.1 → XP_046773678.1  protein numb homolog isoform X1

  18. XM_046917736.1 → XP_046773692.1  protein numb homolog isoform X2

  19. XM_046917744.1 → XP_046773700.1  protein numb homolog isoform X5

  20. XM_046917738.1 → XP_046773694.1  protein numb homolog isoform X3

  21. XM_046917746.1 → XP_046773702.1  protein numb homolog isoform X6

  22. XM_046917727.1 → XP_046773683.1  protein numb homolog isoform X1

  23. XM_046917728.1 → XP_046773684.1  protein numb homolog isoform X1

  24. XM_046917739.1 → XP_046773695.1  protein numb homolog isoform X3

  25. XM_046917747.1 → XP_046773703.1  protein numb homolog isoform X6

  26. XM_046917732.1 → XP_046773688.1  protein numb homolog isoform X1

  27. XM_046917734.1 → XP_046773690.1  protein numb homolog isoform X1

  28. XM_046917741.1 → XP_046773697.1  protein numb homolog isoform X3

Nucleotide Protein Strain
Heading Accession and Version

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