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HDAC2 histone deacetylase 2 [ Gallus gallus (chicken) ]

Gene ID: 395635, updated on 3-Apr-2024

Summary

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Symbol
HDAC2provided by CGNC
Full Name
histone deacetylase 2provided by CGNC
Primary source
CGNC:11140
See related
Ensembl:ENSGALG00010013392
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 3
Exon count:
17
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 3 NC_052534.1 (64512322..64534630)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 3 NC_052575.1 (64293087..64315332)

Chromosome 3 - NC_052534.1Genomic Context describing neighboring genes Neighboring gene heparan sulfate-glucosamine 3-sulfotransferase 5 Neighboring gene uncharacterized LOC121110192 Neighboring gene uncharacterized LOC121110193 Neighboring gene uncharacterized LOC121113157 Neighboring gene translation initiation factor IF-2-like Neighboring gene uncharacterized LOC121110194 Neighboring gene myristoylated alanine rich protein kinase C substrate

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Transcription-dependent association of HDAC2 with active chromatin. Jahan S, et al. J Cell Physiol, 2018 Feb. PMID 28671300
  2. Modulation of immunoglobulin gene conversion frequency and distribution by the histone deacetylase HDAC2 in chicken DT40. Lin W, et al. Genes Cells, 2008 Mar. PMID 18298800
  3. HDAC2 controls IgM H- and L-chain gene expressions via EBF1, Pax5, Ikaros, Aiolos and E2A gene expressions. Nakayama M, et al. Genes Cells, 2007 Mar. PMID 17352740
  4. Distinct roles of HDAC1 and HDAC2 in transcription and recombination at the immunoglobulin loci in the chicken B cell line DT40. Kurosawa K, et al. J Biochem, 2010 Aug. PMID 20511365
  5. Epigenetic influences on sensory regeneration: histone deacetylases regulate supporting cell proliferation in the avian utricle. Slattery EL, et al. J Assoc Res Otolaryngol, 2009 Sep. PMID 19340485, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Unmodified HDAC2 was associated with RNA binding proteins and interacted with RNA bound to the initiating and elongating forms of RNA polymerase II. Phosphorylated HDAC2 was not associated with RNA polymerase II.
    Title: Transcription-dependent association of HDAC2 with active chromatin.
  2. HDAC2(-/-) cells showed a significant enhancement of transcriptional and recombinational activities at both IgL and IgH.
    Title: Distinct roles of HDAC1 and HDAC2 in transcription and recombination at the immunoglobulin loci in the chicken B cell line DT40.
  3. HDAC1 and HDAC2 are positive regulators of regenerative proliferation but they are not critical for avian hair cell differentiation.
    Title: Epigenetic influences on sensory regeneration: histone deacetylases regulate supporting cell proliferation in the avian utricle.
  4. Sequence analysis revealed that the distribution of the gene conversion tracts induced throughout the Ig V regions in HDAC2-/- was significantly different from the diversification patterns in TSA-treated wild-type cultures.
    Title: Modulation of immunoglobulin gene conversion frequency and distribution by the histone deacetylase HDAC2 in chicken DT40.
  5. HDAC2 controls indirectly expressions of IgM H- and L-chain genes through opposite transcriptional regulations of EBF1, Pax5, Aiolos plus Ikaros and E2A genes.
    Title: HDAC2 controls IgM H- and L-chain gene expressions via EBF1, Pax5, Ikaros, Aiolos and E2A gene expressions.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables histone deacetylase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
histone deacetylase 2
Names
HD2
protein deacylase HDAC2
NP_990162.3
XP_015139980.2
XP_046769000.1
XP_046769001.1
XP_046769002.1
XP_046769003.1
XP_046769004.1
XP_046794407.1
XP_046794408.1
XP_046794409.1
XP_046794410.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_204831.3 → NP_990162.3  histone deacetylase 2

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000065
    UniProtKB/Swiss-Prot
    P56519
    UniProtKB/TrEMBL
    A0A8V0YJQ6
    Related
    ENSGALP00010019046.1, ENSGALT00010032256.1
    Conserved Domains (2) summary
    cd10011
    Location:9 → 374
    HDAC2; Histone deacetylase 2 (HDAC2)
    COG4547
    Location:386 → 479
    CobT2; Cobalamin biosynthesis protein CobT (nicotinate-mononucleotide:5, 6-dimethylbenzimidazole phosphorib... [Coenzyme transport and metabolism]

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052534.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    64512322..64534630
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046938452.1 → XP_046794408.1  histone deacetylase 2 isoform X1

    UniProtKB/TrEMBL
    A0A8V0YKC7
    Related
    ENSGALP00010019039.1, ENSGALT00010032249.1

  2. XM_046938453.1 → XP_046794409.1  histone deacetylase 2 isoform X1

    UniProtKB/TrEMBL
    A0A8V0YKC7

  3. XM_046938454.1 → XP_046794410.1  histone deacetylase 2 isoform X1

    UniProtKB/TrEMBL
    A0A8V0YKC7

  4. XM_015284494.4 → XP_015139980.2  histone deacetylase 2 isoform X1

    UniProtKB/TrEMBL
    A0A8V0YKC7, A0A8V0YS62
    Conserved Domains (2) summary
    COG4547
    Location:356 → 449
    CobT2; Cobalamin biosynthesis protein CobT (nicotinate-mononucleotide:5, 6-dimethylbenzimidazole phosphorib... [Coenzyme transport and metabolism]
    cl17011
    Location:1 → 344
    Arginase_HDAC; Arginase-like and histone-like hydrolases

  5. XM_046938451.1 → XP_046794407.1  histone deacetylase 2 isoform X1

    UniProtKB/TrEMBL
    A0A8V0YKC7

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052575.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    64293087..64315332
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046913046.1 → XP_046769002.1  histone deacetylase 2 isoform X1

    Conserved Domains (2) summary
    COG4547
    Location:356 → 449
    CobT2; Cobalamin biosynthesis protein CobT (nicotinate-mononucleotide:5, 6-dimethylbenzimidazole phosphorib... [Coenzyme transport and metabolism]
    cl17011
    Location:1 → 344
    Arginase_HDAC; Arginase-like and histone-like hydrolases

  2. XM_046913047.1 → XP_046769003.1  histone deacetylase 2 isoform X1

    Conserved Domains (2) summary
    COG4547
    Location:356 → 449
    CobT2; Cobalamin biosynthesis protein CobT (nicotinate-mononucleotide:5, 6-dimethylbenzimidazole phosphorib... [Coenzyme transport and metabolism]
    cl17011
    Location:1 → 344
    Arginase_HDAC; Arginase-like and histone-like hydrolases

  3. XM_046913048.1 → XP_046769004.1  histone deacetylase 2 isoform X1

    Conserved Domains (2) summary
    COG4547
    Location:356 → 449
    CobT2; Cobalamin biosynthesis protein CobT (nicotinate-mononucleotide:5, 6-dimethylbenzimidazole phosphorib... [Coenzyme transport and metabolism]
    cl17011
    Location:1 → 344
    Arginase_HDAC; Arginase-like and histone-like hydrolases

  4. XM_046913044.1 → XP_046769000.1  histone deacetylase 2 isoform X1

    Conserved Domains (2) summary
    COG4547
    Location:356 → 449
    CobT2; Cobalamin biosynthesis protein CobT (nicotinate-mononucleotide:5, 6-dimethylbenzimidazole phosphorib... [Coenzyme transport and metabolism]
    cl17011
    Location:1 → 344
    Arginase_HDAC; Arginase-like and histone-like hydrolases

  5. XM_046913045.1 → XP_046769001.1  histone deacetylase 2 isoform X1

    Conserved Domains (2) summary
    COG4547
    Location:356 → 449
    CobT2; Cobalamin biosynthesis protein CobT (nicotinate-mononucleotide:5, 6-dimethylbenzimidazole phosphorib... [Coenzyme transport and metabolism]
    cl17011
    Location:1 → 344
    Arginase_HDAC; Arginase-like and histone-like hydrolases
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P56519.1 GenPept UniProtKB/Swiss-Prot:P56519

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