SHH sonic hedgehog [Gallus gallus (chicken)] - Gene

Summary

Symbol: SHHprovided by CGNC
Full Name: sonic hedgehogprovided by CGNC
Primary source: CGNC:49404
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as: ShhNC
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 2

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	2	NC_052533.1 (8087761..8097333, complement)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	2	NC_052574.1 (8113954..8123546, complement)

Chromosome 2 - NC_052533.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Transient agonism of the sonic hedgehog pathway triggers a permanent transition of skin appendage fate in the chicken embryo.
Title: Transient agonism of the sonic hedgehog pathway triggers a permanent transition of skin appendage fate in the chicken embryo.
miR-199 family contributes to regulation of sonic hedgehog expression during craniofacial development.
Title: miR-199 family contributes to regulation of sonic hedgehog expression during craniofacial development.
The correct location of sonic hedgehog protein (SHH) expression is vital to the formation of the motor column.
Title: Effect of sonic hedgehog on motor neuron positioning in the spinal cord during chicken embryonic development.
AKT stimulates the Shh activity to induce lateral motor columnar motor neurons through the stabilization of ARHGAP36 proteins.
Title: Critical roles of ARHGAP36 as a signal transduction mediator of Shh pathway in lateral motor columnar specification.
the effects of recombinant Shh and the distribution of Gli-1 during in vitro and in situ embryonic chick skeletal muscle differentiation at later stages of development.
Title: Sonic Hedgehog signaling and Gli-1 during embryonic chick myogenesis.
cAMP dependent protein kinase A (PKA) is a key intracellular factor mediating SHH signaling through regulation of GLI3 processing.
Title: SHH ventralizes the otocyst by maintaining basal PKA activity and regulating GLI3 signaling.
propose a model in which positive and negative transcriptional regulatory networks accumulate their functions in the intersection area of their expression regions to provide a restricted spot for the ZPA (zone of polarizing activity), the source of morphogen, Shh.
Title: Upstream regulation for initiation of restricted Shh expression in the chick limb bud.
SHH determines the formation of spinal cord during the development of chicken embryo.
Title: Sonic hedgehog overexpression regulates the neuroepithelial cells proliferation in the spinal cord of dorsal regions during chicken embryo development.
An intrinsic cell cycle clock in polarizing region cells of the chick limb bud times the duration of Sonic hedgehog (Shh) expression, which encodes the morphogen specifying digit pattern across the antero-posterior axis (thumb to little finger).
Title: Sonic hedgehog-expressing cells in the developing limb measure time by an intrinsic cell cycle clock.
These data identify Notch signalling as a novel modulator of Shh signalling that acts mechanistically via regulation of ciliary localisation of key components of its transduction machinery.
Title: A conserved role for Notch signaling in priming the cellular response to Shh through ciliary localisation of the key Shh transducer Smo.

Submit: New GeneRIF Correction See all GeneRIFs (72)

General gene information

Go to the top of the page Help

Markers

ST10BE621 (e-PCR)
- UniSTS:469930

ROS0101 (e-PCR), detects polymorphism
- UniSTS:280280

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info	PubMed
enables patched binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in cell fate specification	IEA Inferred from Electronic Annotation more info	PubMed
involved_in cell-cell signaling	IEA Inferred from Electronic Annotation more info	PubMed
involved_in intein-mediated protein splicing	IEA Inferred from Electronic Annotation more info	PubMed
involved_in multicellular organism development	IEA Inferred from Electronic Annotation more info	PubMed
involved_in oligodendrocyte differentiation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in protein autoprocessing	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of gene expression	IEA Inferred from Electronic Annotation more info	PubMed
involved_in smoothened signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular space	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: sonic hedgehog protein

Names: shh unprocessed N-terminal signaling and C-terminal autoprocessing domains; sonic hedgehog homolog

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_204821.1 → NP_990152.1 sonic hedgehog protein precursor

See identical proteins and their annotated locations for NP_990152.1

Status: PROVISIONAL

Source sequence(s)

L28099

UniProtKB/Swiss-Prot

Q91035

Conserved Domains (3) summary

cd00081
Location:201 → 352

Hint; Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein, ...

pfam01079
Location:190 → 411

Hint; Hint module

pfam01085
Location:42 → 187

HH_signal; Hedgehog amino-terminal signalling domain

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

NC_052533.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Range

8087761..8097333 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)