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MDM2 MDM2 proto-oncogene [ Gallus gallus (chicken) ]

Gene ID: 395609, updated on 3-Apr-2024

Summary

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Symbol
MDM2provided by CGNC
Full Name
MDM2 proto-oncogeneprovided by CGNC
Primary source
CGNC:7552
See related
Ensembl:ENSGALG00010012683
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 1
Exon count:
11
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 1 NC_052532.1 (35421927..35438703)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 1 NC_052573.1 (35769252..35786059)

Chromosome 1 - NC_052532.1Genomic Context describing neighboring genes Neighboring gene nucleoporin 107 Neighboring gene solute carrier family 35 member E3 Neighboring gene uncharacterized LOC101752108 Neighboring gene carboxypeptidase M Neighboring gene uncharacterized LOC121109492 Neighboring gene cleavage and polyadenylation specific factor 6 Neighboring gene uncharacterized LOC107052751

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Gene pathways and cell cycle-related genes in cultured avian primordial germ cells. Rengaraj D, et al. Poult Sci, 2012 Dec. PMID 23155027

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables ubiquitin protein ligase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of cell cycle IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
E3 ubiquitin-protein ligase Mdm2
Names
MDM2 oncogene, E3 ubiquitin protein ligase
MDM2 proto-oncogene, E3 ubiquitin protein ligase
Mdm2, p53 E3 ubiquitin protein ligase homolog
NP_001186313.1
XP_015133124.1
XP_024998096.1
XP_040506981.1
XP_040507063.1
XP_046761061.1
XP_046762605.1
XP_046762606.1
XP_046762607.1
XP_046762608.1
XP_046762609.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001199384.2 → NP_001186313.1  E3 ubiquitin-protein ligase Mdm2

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000012
    UniProtKB/TrEMBL
    A0A8V0YA47, F1NGX6
    Conserved Domains (4) summary
    cd16783
    Location:427 → 483
    mRING-HC-C2H2C4_MDM2; Modified RING finger, HC subclass (C2H2C4-type), found in E3 ubiquitin-protein ligase MDM2 and similar proteins
    cd17672
    Location:21 → 103
    MDM2; p53-binding domain found in E3 ubiquitin-protein ligase MDM2 and similar proteins
    pfam00641
    Location:293 → 322
    zf-RanBP; Zn-finger in Ran binding protein and others
    NF033845
    Location:105 → 295
    MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052532.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    35421927..35438703
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_040651047.2 → XP_040506981.1  E3 ubiquitin-protein ligase Mdm2 isoform X1

    UniProtKB/TrEMBL
    A0A8V0YA47, F1NGX6
    Related
    ENSGALP00010017604.1, ENSGALT00010030350.1
    Conserved Domains (4) summary
    cd16783
    Location:427 → 483
    mRING-HC-C2H2C4_MDM2; Modified RING finger, HC subclass (C2H2C4-type), found in E3 ubiquitin-protein ligase MDM2 and similar proteins
    cd17672
    Location:21 → 103
    MDM2; p53-binding domain found in E3 ubiquitin-protein ligase MDM2 and similar proteins
    pfam00641
    Location:293 → 322
    zf-RanBP; Zn-finger in Ran binding protein and others
    NF033845
    Location:105 → 295
    MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB

  2. XM_025142328.3 → XP_024998096.1  E3 ubiquitin-protein ligase Mdm2 isoform X2

    UniProtKB/TrEMBL
    A0A8V0YA47
    Conserved Domains (3) summary
    pfam00641
    Location:292 → 321
    zf-RanBP; Zn-finger in Ran binding protein and others
    pfam02201
    Location:41 → 92
    SWIB; SWIB/MDM2 domain
    cd16783
    Location:426 → 482
    mRING-HC-C2H2C4_MDM2; Modified RING finger, HC subclass (C2H2C4-type), found in E3 ubiquitin-protein ligase MDM2 and similar proteins

  3. XM_040651129.2 → XP_040507063.1  E3 ubiquitin-protein ligase Mdm2 isoform X4

    UniProtKB/TrEMBL
    A0A8V0YA47
    Conserved Domains (2) summary
    cd16783
    Location:330 → 386
    mRING-HC-C2H2C4_MDM2; Modified RING finger, HC subclass (C2H2C4-type), found in E3 ubiquitin-protein ligase MDM2 and similar proteins
    NF000535
    Location:43 → 198
    MSCRAMM_SdrC; MSCRAMM family adhesin SdrC

  4. XM_015277638.4 → XP_015133124.1  E3 ubiquitin-protein ligase Mdm2 isoform X3

    UniProtKB/TrEMBL
    A0A8V0YA47
    Related
    ENSGALP00010017598.1, ENSGALT00010030339.1
    Conserved Domains (3) summary
    pfam00641
    Location:248 → 277
    zf-RanBP; Zn-finger in Ran binding protein and others
    pfam02201
    Location:1 → 43
    SWIB; SWIB/MDM2 domain
    pfam13920
    Location:381 → 430
    zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)

  5. XM_046905105.1 → XP_046761061.1  E3 ubiquitin-protein ligase Mdm2 isoform X4

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052573.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    35769252..35786059
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046906649.1 → XP_046762605.1  E3 ubiquitin-protein ligase Mdm2 isoform X1

    UniProtKB/TrEMBL
    F1NGX6

  2. XM_046906650.1 → XP_046762606.1  E3 ubiquitin-protein ligase Mdm2 isoform X2

  3. XM_046906652.1 → XP_046762608.1  E3 ubiquitin-protein ligase Mdm2 isoform X4

  4. XM_046906651.1 → XP_046762607.1  E3 ubiquitin-protein ligase Mdm2 isoform X3

  5. XM_046906653.1 → XP_046762609.1  E3 ubiquitin-protein ligase Mdm2 isoform X4

Nucleotide Protein Strain
Heading Accession and Version

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