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SPRY2 sprouty RTK signaling antagonist 2 [ Gallus gallus (chicken) ]

Gene ID: 395584, updated on 5-Mar-2024

Summary

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Symbol
SPRY2provided by CGNC
Full Name
sprouty RTK signaling antagonist 2provided by CGNC
Primary source
CGNC:49386
See related
Ensembl:ENSGALG00010000711
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 1
Exon count:
5
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 1 NC_052532.1 (152630538..152636591)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 1 NC_052573.1 (152525473..152531544)

Chromosome 1 - NC_052532.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107051569 Neighboring gene uncharacterized LOC121108088 Neighboring gene uncharacterized LOC101750454 Neighboring gene uncharacterized LOC107051901 Neighboring gene Nedd4 family interacting protein 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Sprouty2 mediated tuning of signalling is essential for somite myogenesis. Abu-Elmagd M, et al. BMC Med Genomics, 2015. PMID 25783674, Free PMC Article
  2. Stage-dependent craniofacial defects resulting from Sprouty2 overexpression. Goodnough LH, et al. Dev Dyn, 2007 Jul. PMID 17576140
  3. Activation of Ras-ERK pathway by Fgf8 and its downregulation by Sprouty2 for the isthmus organizing activity. Suzuki-Hirano A, et al. Dev Biol, 2010 Jan 15. PMID 19896936
  4. Regulation of isthmic Fgf8 signal by sprouty2. Suzuki-Hirano A, et al. Development, 2005 Jan. PMID 15590739
  5. Differential display of genes expressed at the midbrain - hindbrain junction identifies sprouty2: an FGF8-inducible member of a family of intracellular FGF antagonists. Chambers D, et al. Mol Cell Neurosci, 2000 Jan. PMID 10662503

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Spry2 function during chick somite myogenesis
    Title: Sprouty2 mediated tuning of signalling is essential for somite myogenesis.
  2. 'Prolonged' activation of ERK by misexpression of Fgf8b and dominant-negative Sprouty2 (dnSprouty2) did not change the fate of the mesencephalic alar plate.
    Title: Activation of Ras-ERK pathway by Fgf8 and its downregulation by Sprouty2 for the isthmus organizing activity.
  3. Sprouty2 plays a role in the outgrowth of facial prominences independent of canonical fibroblast growth factor signaling.
    Title: Stage-dependent craniofacial defects resulting from Sprouty2 overexpression.
  4. Sprouty2 may regulate the Fgf8-Ras-ERK signaling pathway for the proper regionalization of the metencephalon and mesencephalon
    Title: Regulation of isthmic Fgf8 signal by sprouty2.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Process Evidence Code Pubs
involved_in animal organ development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in multicellular organism development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of MAP kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of Ras protein signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of fibroblast growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
protein sprouty homolog 2
Names
sprouty 2
sprouty homolog 2
spry-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001397684.1 → NP_001384613.1  protein sprouty homolog 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has the short intron.
    Source sequence(s)
    AF176904, BM487657
    UniProtKB/TrEMBL
    A0A8V0X3L8
    Related
    ENSGALP00010000823.1, ENSGALT00010001518.1

  2. NM_204800.2 → NP_990131.2  protein sprouty homolog 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) has the long intron.
    Source sequence(s)
    AF176904, BM487657, JAENSK010000026
    UniProtKB/TrEMBL
    A0A8V0X3L8
    Related
    ENSGALP00010000822.1, ENSGALT00010001516.1

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052532.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    152630538..152636591
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015275123.4 → XP_015130609.2  protein sprouty homolog 2 isoform X1

    UniProtKB/TrEMBL
    A0A8V0X3L8
    Related
    ENSGALP00010000821.1, ENSGALT00010001515.1

  2. XM_015275119.4 → XP_015130605.2  protein sprouty homolog 2 isoform X1

    UniProtKB/TrEMBL
    A0A8V0X3L8

  3. XM_046905019.1 → XP_046760975.1  protein sprouty homolog 2 isoform X1

    UniProtKB/TrEMBL
    A0A8V0X3L8
    Related
    ENSGALP00010000820.1, ENSGALT00010001514.1

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052573.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    152525473..152531544
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046906646.1 → XP_046762602.1  protein sprouty homolog 2 isoform X1

    UniProtKB/Swiss-Prot
    Q9PTL2

  2. XM_046906647.1 → XP_046762603.1  protein sprouty homolog 2 isoform X1

    UniProtKB/Swiss-Prot
    Q9PTL2

  3. XM_046906648.1 → XP_046762604.1  protein sprouty homolog 2 isoform X1

    UniProtKB/Swiss-Prot
    Q9PTL2
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9PTL2.1 GenPept UniProtKB/Swiss-Prot:Q9PTL2

Gene LinkOut

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