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PAX2 paired box 2 [ Gallus gallus (chicken) ]

Gene ID: 395574, updated on 3-Apr-2024

Summary

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Symbol
PAX2provided by CGNC
Full Name
paired box 2provided by CGNC
Primary source
CGNC:4240
See related
Ensembl:ENSGALG00010021060
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
PAX-2
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 6
Exon count:
14
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 6 NC_052537.1 (17860442..17953147, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 6 NC_052578.1 (17846484..17939064, complement)

Chromosome 6 - NC_052537.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101749795 Neighboring gene F-box and leucine rich repeat protein 15 Neighboring gene CUE domain containing 2 Neighboring gene transfer RNA glutamic acid (anticodon UUC) Neighboring gene uncharacterized LOC121111212 Neighboring gene microRNA 6577

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Expression of the Pax2 transcription factor is associated with vestibular phenotype in the avian inner ear. Warchol ME, et al. Dev Neurobiol, 2009 Feb 1-15. PMID 19130600, Free PMC Article
  2. Ectopic Pax2 expression in chick ventral optic cup phenocopies loss of Pax2 expression. Sehgal R, et al. Dev Biol, 2008 Jul 1. PMID 18485342, Free PMC Article
  3. Pax2 expression patterns in the developing chick inner ear. Sánchez-Calderón H, et al. Gene Expr Patterns, 2005 Aug. PMID 15979948
  4. Correlation of Pax-2 expression with cell proliferation in the developing chicken inner ear. Li H, et al. J Neurobiol, 2004 Jul. PMID 15188273
  5. Potential role of Pax-2 in retinal axon navigation through the chick optic nerve stalk and optic chiasm. Thanos S, et al. J Neurobiol, 2004 Apr. PMID 15007823

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data show that one of the oviduct-related genes, paired box 2, was identified and may serve as a marker of the disease.
    Title: Gene expression profiling reveals differentially expressed genes in ovarian cancer of the hen: support for oviductal origin?
  2. PAX2 and PEA3 synergize to activate a novel regulatory enhancer for spalt4 in the developing ear.
    Title: Pax2 and Pea3 synergize to activate a novel regulatory enhancer for spalt4 in the developing ear.
  3. The results of this study indicate that Pax2 continues to be expressed in the mature avian ear, and that its expression pattern is correlated with a vestibular phenotype.
    Title: Expression of the Pax2 transcription factor is associated with vestibular phenotype in the avian inner ear.
  4. In ovo electroporation of Pax2 into the chick ventral optic cup results in the formation of colobomas, a condition typically associated with a loss of Pax2 expression.
    Title: Ectopic Pax2 expression in chick ventral optic cup phenocopies loss of Pax2 expression.
  5. a signaling cascade that involves successively Sonic hedgehog and FGF is required to maintain Pax2 expression in optic nerve precursors
    Title: Pax2 regulates neuronal-glial cell fate choice in the embryonic optic nerve.
  6. The data of this study suggest that balanced expression of Pax-2 results in the correct formation of the chick chiasm at early stages by imposing accurate pathfinding within the optic stalk and the midline.
    Title: Potential role of Pax-2 in retinal axon navigation through the chick optic nerve stalk and optic chiasm.
  7. Chick embryo parvicellular isthmic nucleus cells rapidly down-regulated an early transient Pax2 signal; this pattern is consistent with its reported isthmic origin and forward tangential translocation.
    Title: A distinct preisthmic histogenetic domain is defined by overlap of Otx2 and Pax2 gene expression in the avian caudal midbrain.
  8. a marker for proliferating hair and supporting cell progenitors
    Title: Correlation of Pax-2 expression with cell proliferation in the developing chicken inner ear.
  9. Pax2 expression patterns during the development of the chick inner ear.
    Title: Pax2 expression patterns in the developing chick inner ear.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in anatomical structure development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
paired box protein Pax-2
Names
paired box gene 2
paired-box containing protein Pax-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_204793.3 → NP_990124.1  paired box protein Pax-2

    See identical proteins and their annotated locations for NP_990124.1

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000231
    UniProtKB/TrEMBL
    A0A8V0ZN87, Q9PTX1
    Related
    ENSGALP00010030151.1, ENSGALT00010050960.1
    Conserved Domains (3) summary
    smart00351
    Location:16 → 140
    PAX; Paired Box domain
    pfam12403
    Location:282 → 392
    Pax2_C; Paired-box protein 2 C terminal
    cl00084
    Location:232 → 255
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052537.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    17860442..17953147 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_025151472.3 → XP_025007240.1  paired box protein Pax-2 isoform X2

    UniProtKB/TrEMBL
    A0A8V0ZH56
    Conserved Domains (3) summary
    smart00351
    Location:88 → 212
    PAX; Paired Box domain
    pfam12403
    Location:454 → 563
    Pax2_C; Paired-box protein 2 C terminal
    cl00084
    Location:304 → 327
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

  2. XM_025151477.3 → XP_025007245.1  paired box protein Pax-2 isoform X8

    UniProtKB/TrEMBL
    A0A8V0ZH56
    Related
    ENSGALP00010030154.1, ENSGALT00010050963.1
    Conserved Domains (3) summary
    smart00351
    Location:89 → 213
    PAX; Paired Box domain
    pfam12403
    Location:355 → 465
    Pax2_C; Paired-box protein 2 C terminal
    cl00084
    Location:305 → 328
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

  3. XM_025151471.3 → XP_025007239.1  paired box protein Pax-2 isoform X1

    UniProtKB/TrEMBL
    A0A8V0ZH56
    Conserved Domains (3) summary
    smart00351
    Location:89 → 213
    PAX; Paired Box domain
    pfam12403
    Location:455 → 564
    Pax2_C; Paired-box protein 2 C terminal
    cl00084
    Location:305 → 328
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

  4. XM_040702268.2 → XP_040558202.1  paired box protein Pax-2 isoform X7

    UniProtKB/TrEMBL
    A0A8V0ZH94
    Conserved Domains (1) summary
    smart00351
    Location:15 → 139
    PAX; Paired Box domain

  5. XM_040702269.2 → XP_040558203.1  paired box protein Pax-2 isoform X11

    UniProtKB/TrEMBL
    A0A8V0ZNA0
    Conserved Domains (1) summary
    smart00351
    Location:15 → 139
    PAX; Paired Box domain

  6. XM_015288366.4 → XP_015143852.1  paired box protein Pax-2 isoform X12

    UniProtKB/TrEMBL
    A0A8V0ZN87
    Conserved Domains (3) summary
    smart00351
    Location:15 → 139
    PAX; Paired Box domain
    pfam12403
    Location:281 → 391
    Pax2_C; Paired-box protein 2 C terminal
    cl00084
    Location:231 → 254
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

  7. XM_040702267.2 → XP_040558201.1  paired box protein Pax-2 isoform X6

    UniProtKB/TrEMBL
    A0A8V0ZH94
    Conserved Domains (3) summary
    smart00351
    Location:15 → 139
    PAX; Paired Box domain
    pfam12403
    Location:350 → 441
    Pax2_C; Paired-box protein 2 C terminal
    cl00084
    Location:231 → 254
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

  8. XM_040702270.2 → XP_040558204.1  paired box protein Pax-2 isoform X14

    UniProtKB/TrEMBL
    A0A8V0ZA57, A0A8V0ZH94
    Related
    ENSGALP00010030170.1, ENSGALT00010050979.1
    Conserved Domains (3) summary
    smart00351
    Location:15 → 139
    PAX; Paired Box domain
    pfam12403
    Location:350 → 461
    Pax2_C; Paired-box protein 2 C terminal
    cl00084
    Location:231 → 254
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

  9. XM_015288358.4 → XP_015143844.1  paired box protein Pax-2 isoform X4

    UniProtKB/TrEMBL
    A0A8V0ZH94
    Conserved Domains (3) summary
    smart00351
    Location:15 → 139
    PAX; Paired Box domain
    pfam12403
    Location:381 → 490
    Pax2_C; Paired-box protein 2 C terminal
    cl00084
    Location:231 → 254
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

  10. XM_015288368.4 → XP_015143854.1  paired box protein Pax-2 isoform X13

    UniProtKB/TrEMBL
    A0A8V0ZN87
    Conserved Domains (3) summary
    smart00351
    Location:16 → 140
    PAX; Paired Box domain
    pfam12403
    Location:242 → 352
    Pax2_C; Paired-box protein 2 C terminal
    cl00084
    Location:192 → 215
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

  11. XM_015288365.4 → XP_015143851.1  paired box protein Pax-2 isoform X10

    UniProtKB/TrEMBL
    A0A8V0ZNA0
    Related
    ENSGALP00010030166.1, ENSGALT00010050975.1
    Conserved Domains (3) summary
    smart00351
    Location:16 → 140
    PAX; Paired Box domain
    pfam12403
    Location:282 → 372
    Pax2_C; Paired-box protein 2 C terminal
    cl00084
    Location:232 → 255
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

  12. XM_015288361.4 → XP_015143847.1  paired box protein Pax-2 isoform X5

    UniProtKB/TrEMBL
    A0A8V0ZH94
    Related
    ENSGALP00010030158.1, ENSGALT00010050967.1
    Conserved Domains (3) summary
    smart00351
    Location:16 → 140
    PAX; Paired Box domain
    pfam12403
    Location:351 → 442
    Pax2_C; Paired-box protein 2 C terminal
    cl00084
    Location:232 → 255
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

  13. XM_015288364.4 → XP_015143850.1  paired box protein Pax-2 isoform X9

    UniProtKB/TrEMBL
    A0A8V0ZH94
    Related
    ENSGALP00010030173.1, ENSGALT00010050982.1
    Conserved Domains (3) summary
    smart00351
    Location:16 → 140
    PAX; Paired Box domain
    pfam12403
    Location:351 → 462
    Pax2_C; Paired-box protein 2 C terminal
    cl00084
    Location:232 → 255
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

  14. XM_015288357.4 → XP_015143843.1  paired box protein Pax-2 isoform X3

    UniProtKB/TrEMBL
    A0A8V0ZH94
    Conserved Domains (3) summary
    smart00351
    Location:16 → 140
    PAX; Paired Box domain
    pfam12403
    Location:382 → 491
    Pax2_C; Paired-box protein 2 C terminal
    cl00084
    Location:232 → 255
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

  15. XM_040702262.2 → XP_040558196.1  paired box protein Pax-2 isoform X23

    UniProtKB/TrEMBL
    A0A8V0ZN96
    Conserved Domains (1) summary
    smart00351
    Location:217 → 341
    PAX; Paired Box domain

  16. XM_040702257.2 → XP_040558191.1  paired box protein Pax-2 isoform X18

    Conserved Domains (1) summary
    smart00351
    Location:217 → 341
    PAX; Paired Box domain

  17. XM_040702266.2 → XP_040558200.1  paired box protein Pax-2 isoform X27

    UniProtKB/TrEMBL
    A0A8V0ZH67
    Related
    ENSGALP00010030164.1, ENSGALT00010050973.1
    Conserved Domains (1) summary
    smart00351
    Location:217 → 341
    PAX; Paired Box domain

  18. XM_040702260.2 → XP_040558194.1  paired box protein Pax-2 isoform X21

    UniProtKB/TrEMBL
    A0A8V0ZN96
    Related
    ENSGALP00010030161.1, ENSGALT00010050970.1
    Conserved Domains (1) summary
    smart00351
    Location:217 → 341
    PAX; Paired Box domain

  19. XM_040702261.2 → XP_040558195.1  paired box protein Pax-2 isoform X22

    UniProtKB/TrEMBL
    A0A8V0ZN96
    Conserved Domains (1) summary
    smart00351
    Location:217 → 341
    PAX; Paired Box domain

  20. XM_040702256.2 → XP_040558190.1  paired box protein Pax-2 isoform X17

    Conserved Domains (1) summary
    smart00351
    Location:217 → 341
    PAX; Paired Box domain

  21. XM_040702258.2 → XP_040558192.1  paired box protein Pax-2 isoform X19

    Conserved Domains (1) summary
    smart00351
    Location:217 → 341
    PAX; Paired Box domain

  22. XM_040702259.2 → XP_040558193.1  paired box protein Pax-2 isoform X20

    UniProtKB/TrEMBL
    A0A8V0ZN96
    Conserved Domains (1) summary
    smart00351
    Location:217 → 341
    PAX; Paired Box domain

  23. XM_040702254.2 → XP_040558188.1  paired box protein Pax-2 isoform X15

    Conserved Domains (1) summary
    smart00351
    Location:217 → 341
    PAX; Paired Box domain

  24. XM_040702255.2 → XP_040558189.1  paired box protein Pax-2 isoform X16

    Conserved Domains (1) summary
    smart00351
    Location:217 → 341
    PAX; Paired Box domain

  25. XM_040702264.2 → XP_040558198.1  paired box protein Pax-2 isoform X26

    Conserved Domains (1) summary
    smart00351
    Location:217 → 341
    PAX; Paired Box domain

  26. XM_040702265.2 → XP_040558199.1  paired box protein Pax-2 isoform X26

    Conserved Domains (1) summary
    smart00351
    Location:217 → 341
    PAX; Paired Box domain

  27. XM_025151483.3 → XP_025007251.2  paired box protein Pax-2 isoform X29

    UniProtKB/TrEMBL
    A0A8V0ZN96
    Conserved Domains (1) summary
    smart00351
    Location:217 → 341
    PAX; Paired Box domain

  28. XM_025151482.3 → XP_025007250.2  paired box protein Pax-2 isoform X28

    UniProtKB/TrEMBL
    A0A8V0ZN96
    Conserved Domains (1) summary
    smart00351
    Location:217 → 341
    PAX; Paired Box domain

  29. XM_040702263.2 → XP_040558197.1  paired box protein Pax-2 isoform X25

    UniProtKB/TrEMBL
    A0A8V0ZN96
    Conserved Domains (1) summary
    smart00351
    Location:217 → 341
    PAX; Paired Box domain

  30. XM_025151478.3 → XP_025007246.2  paired box protein Pax-2 isoform X24

    UniProtKB/TrEMBL
    A0A8V0ZN96
    Conserved Domains (1) summary
    smart00351
    Location:217 → 341
    PAX; Paired Box domain

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052578.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    17846484..17939064 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046919888.1 → XP_046775844.1  paired box protein Pax-2 isoform X2

  2. XM_046919895.1 → XP_046775851.1  paired box protein Pax-2 isoform X8

  3. XM_046919887.1 → XP_046775843.1  paired box protein Pax-2 isoform X1

  4. XM_046919894.1 → XP_046775850.1  paired box protein Pax-2 isoform X7

  5. XM_046919898.1 → XP_046775854.1  paired box protein Pax-2 isoform X11

  6. XM_046919899.1 → XP_046775855.1  paired box protein Pax-2 isoform X12

  7. XM_046919893.1 → XP_046775849.1  paired box protein Pax-2 isoform X6

  8. XM_046919901.1 → XP_046775857.1  paired box protein Pax-2 isoform X14

    UniProtKB/TrEMBL
    A0A8V0ZA57

  9. XM_046919891.1 → XP_046775847.1  paired box protein Pax-2 isoform X4

  10. XM_046919900.1 → XP_046775856.1  paired box protein Pax-2 isoform X13

  11. XM_046919897.1 → XP_046775853.1  paired box protein Pax-2 isoform X10

  12. XM_046919892.1 → XP_046775848.1  paired box protein Pax-2 isoform X5

  13. XM_046919896.1 → XP_046775852.1  paired box protein Pax-2 isoform X9

  14. XM_046919890.1 → XP_046775846.1  paired box protein Pax-2 isoform X3

  15. XM_046919889.1 → XP_046775845.1  paired box protein Pax-2 isoform X31

  16. XM_046919886.1 → XP_046775842.1  paired box protein Pax-2 isoform X30

Nucleotide Protein Strain
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