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PDGFRA platelet-derived growth factor receptor, alpha polypeptide [ Gallus gallus (chicken) ]

Gene ID: 395509, updated on 3-Apr-2024

Summary

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Symbol
PDGFRAprovided by CGNC
Full Name
platelet-derived growth factor receptor, alpha polypeptideprovided by CGNC
Primary source
CGNC:10416
See related
Ensembl:ENSGALG00010013621
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
PDGFR; PDGFR-A
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 4
Exon count:
23
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 4 NC_052535.1 (64913447..64948001, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 4 NC_052576.1 (64896345..64930840, complement)

Chromosome 4 - NC_052535.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC112532339 Neighboring gene KIT proto-oncogene, receptor tyrosine kinase Neighboring gene uncharacterized LOC124417930 Neighboring gene arginine/serine-rich protein 45-like Neighboring gene GS homeobox 2-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Platelet-derived growth factor A modulates limb chondrogenesis both in vivo and in vitro. Ataliotis P. Mech Dev, 2000 Jun. PMID 10842055
  2. Platelet-derived growth factor is involved in the differentiation of second heart field-derived cardiac structures in chicken embryos. Bax NA, et al. Dev Dyn, 2009 Oct. PMID 19705434
  3. Disruption of PDGFRalpha-initiated PI3K activation and migration of somite derivatives leads to spina bifida. Pickett EA, et al. Development, 2008 Feb. PMID 18192285, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Results describe the expression patterns of PDGF-A, -C, and their receptor PDGFR-alpha during avian heart development.
    Title: Platelet-derived growth factor is involved in the differentiation of second heart field-derived cardiac structures in chicken embryos.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables platelet-derived growth factor alpha-receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables platelet-derived growth factor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in embryonic cranial skeleton morphogenesis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in multicellular organism development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in platelet-derived growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of receptor complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
platelet-derived growth factor receptor alpha
Names
PDGF-R-alpha
PDGFR-alpha
Pre-mRNA 3'-end-processing factor FIP1
alpha platelet-derived growth factor receptor
alpha-type platelet-derived growth factor receptor
tyrosine kinase PDGFR
NP_990080.3
XP_015140900.2
XP_046771434.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_204749.3 → NP_990080.3  platelet-derived growth factor receptor alpha precursor

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000074
    UniProtKB/Swiss-Prot
    Q9PUF6
    UniProtKB/TrEMBL
    A0A8V0YLC3
    Related
    ENSGALP00010019398.1, ENSGALT00010032740.1
    Conserved Domains (4) summary
    cd05105
    Location:555 → 956
    PTKc_PDGFR_alpha; Catalytic domain of the Protein Tyrosine Kinase, Platelet Derived Growth Factor Receptor alpha
    smart00409
    Location:223 → 309
    IG; Immunoglobulin
    cd00096
    Location:333 → 341
    Ig; Ig strand B [structural motif]
    cl11960
    Location:331 → 409
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052535.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    64913447..64948001 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015285414.4 → XP_015140900.2  platelet-derived growth factor receptor alpha isoform X1

    UniProtKB/Swiss-Prot
    Q9PUF6
    UniProtKB/TrEMBL
    A0A8V0YLC3
    Conserved Domains (4) summary
    cd05105
    Location:555 → 956
    PTKc_PDGFR_alpha; Catalytic domain of the Protein Tyrosine Kinase, Platelet Derived Growth Factor Receptor alpha
    smart00409
    Location:223 → 309
    IG; Immunoglobulin
    cd00096
    Location:333 → 341
    Ig; Ig strand B [structural motif]
    cl11960
    Location:331 → 409
    Ig; Immunoglobulin domain

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052576.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    64896345..64930840 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046915478.1 → XP_046771434.1  platelet-derived growth factor receptor alpha isoform X1

    UniProtKB/TrEMBL
    A0A8V0YLC3
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9PUF6.1 GenPept UniProtKB/Swiss-Prot:Q9PUF6

Gene LinkOut

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