U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) [ Gallus gallus (chicken) ]

Gene ID: 395508, updated on 3-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
TCF7L2provided by CGNC
Official Full Name
transcription factor 7-like 2 (T-cell specific, HMG-box)provided by CGNC
Primary source
CGNC:49355
See related
Ensembl:ENSGALG00010018901
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
TCF4
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
chromosome: 6
Exon count:
18
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 6 NC_052537.1 (27843304..28015715)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 6 NC_052578.1 (27734046..27906377)

Chromosome 6 - NC_052537.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107053735 Neighboring gene zinc finger DHHC-type containing 6 Neighboring gene vesicle transport through interaction with t-SNAREs 1A Neighboring gene uncharacterized LOC112532720 Neighboring gene uncharacterized LOC124418093

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Pax6 defines the di-mesencephalic boundary by repressing En1 and Pax2. Matsunaga E, et al. Development, 2000 Jun. PMID 10804178
  2. BMPs restrict the position of premuscle masses in the limb buds by influencing Tcf4 expression. Bonafede A, et al. Dev Biol, 2006 Nov 15. PMID 17005177

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. BMP2 and 4 can act as patterning factors by inhibiting the expression of Tcf4, a downstream element of the canonical Wnt pathway.
    Title: BMPs restrict the position of premuscle masses in the limb buds by influencing Tcf4 expression.
Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in canonical Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of beta-catenin-TCF complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of catenin-TCF7L2 complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
transcription factor 7-like 2
Names
transcription factor Tcf4

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001206510.5 → NP_001193439.1  transcription factor 7-like 2

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000232
    UniProtKB/TrEMBL
    E1BYU0
    Conserved Domains (2) summary
    cd01388
    Location:330 → 397
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:17 → 236
    CTNNB1_binding; N-terminal CTNNB1 binding

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052537.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    27843304..28015715
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015288546.4 → XP_015144032.1  transcription factor 7-like 2 isoform X1

    Conserved Domains (2) summary
    cd01388
    Location:335 → 402
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:17 → 236
    CTNNB1_binding; N-terminal CTNNB1 binding

  2. XM_015288547.4 → XP_015144033.1  transcription factor 7-like 2 isoform X2

    Conserved Domains (2) summary
    cd01388
    Location:335 → 402
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:17 → 236
    CTNNB1_binding; N-terminal CTNNB1 binding

  3. XM_015288561.4 → XP_015144047.1  transcription factor 7-like 2 isoform X17

    UniProtKB/TrEMBL
    A0A8V0Z7W8, A0A8V0ZFC1
    Related
    ENSGALP00010027271.1, ENSGALT00010045748.1
    Conserved Domains (2) summary
    cd01388
    Location:335 → 402
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam08347
    Location:17 → 236
    CTNNB1_binding; N-terminal CTNNB1 binding

  4. XM_015288551.4 → XP_015144037.1  transcription factor 7-like 2 isoform X7

    Conserved Domains (2) summary
    cd01388
    Location:335 → 402
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:17 → 236
    CTNNB1_binding; N-terminal CTNNB1 binding

  5. XM_015288550.4 → XP_015144036.1  transcription factor 7-like 2 isoform X6

    Conserved Domains (2) summary
    cd01388
    Location:335 → 402
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:17 → 236
    CTNNB1_binding; N-terminal CTNNB1 binding

  6. XM_015288567.4 → XP_015144053.1  transcription factor 7-like 2 isoform X23

    UniProtKB/TrEMBL
    A0A8V0Z7W8
    Conserved Domains (2) summary
    cd01388
    Location:335 → 402
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam08347
    Location:17 → 236
    CTNNB1_binding; N-terminal CTNNB1 binding

  7. XM_046942722.1 → XP_046798678.1  transcription factor 7-like 2 isoform X4

    UniProtKB/TrEMBL
    A0A8V0Z7Y0
    Related
    ENSGALP00010027267.1, ENSGALT00010045743.1

  8. XM_015288563.4 → XP_015144049.1  transcription factor 7-like 2 isoform X19

    UniProtKB/TrEMBL
    A0A8V0Z7W8
    Conserved Domains (2) summary
    cd01388
    Location:330 → 397
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam08347
    Location:17 → 236
    CTNNB1_binding; N-terminal CTNNB1 binding

  9. XM_015288553.4 → XP_015144039.1  transcription factor 7-like 2 isoform X9

    UniProtKB/TrEMBL
    A0A8V0Z222
    Related
    ENSGALP00010027275.1, ENSGALT00010045754.1
    Conserved Domains (2) summary
    cd01388
    Location:330 → 397
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:17 → 236
    CTNNB1_binding; N-terminal CTNNB1 binding

  10. XM_015288552.4 → XP_015144038.1  transcription factor 7-like 2 isoform X8

    UniProtKB/TrEMBL
    A0A1D5P979
    Related
    ENSGALP00010027246.1, ENSGALT00010045706.1
    Conserved Domains (2) summary
    cd01388
    Location:330 → 397
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:17 → 236
    CTNNB1_binding; N-terminal CTNNB1 binding

  11. XM_015288568.4 → XP_015144054.1  transcription factor 7-like 2 isoform X26

    UniProtKB/TrEMBL
    A0A8V0Z7W8, A0A8V0Z8F7
    Related
    ENSGALP00010027254.1, ENSGALT00010045720.1
    Conserved Domains (2) summary
    cd01388
    Location:330 → 397
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam08347
    Location:17 → 236
    CTNNB1_binding; N-terminal CTNNB1 binding

  12. XM_046942721.1 → XP_046798677.1  transcription factor 7-like 2 isoform X3

  13. XM_040702250.2 → XP_040558184.1  transcription factor 7-like 2 isoform X25

    UniProtKB/TrEMBL
    A0A8V0Z7W8
    Conserved Domains (1) summary
    cd01388
    Location:331 → 398
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

  14. XM_015288549.4 → XP_015144035.1  transcription factor 7-like 2 isoform X5

    Conserved Domains (2) summary
    cd01388
    Location:326 → 393
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:17 → 236
    CTNNB1_binding; N-terminal CTNNB1 binding

  15. XM_015288565.4 → XP_015144051.1  transcription factor 7-like 2 isoform X21

    UniProtKB/TrEMBL
    A0A8V0Z7W8
    Conserved Domains (2) summary
    cd01388
    Location:326 → 393
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam08347
    Location:17 → 236
    CTNNB1_binding; N-terminal CTNNB1 binding

  16. XM_040702245.2 → XP_040558179.1  transcription factor 7-like 2 isoform X10

    Conserved Domains (1) summary
    cd01388
    Location:326 → 393
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

  17. XM_015288569.4 → XP_015144055.1  transcription factor 7-like 2 isoform X27

    UniProtKB/TrEMBL
    A0A8V0Z7W8
    Conserved Domains (2) summary
    cd01388
    Location:326 → 393
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam08347
    Location:17 → 236
    CTNNB1_binding; N-terminal CTNNB1 binding

  18. XM_046942723.1 → XP_046798679.1  transcription factor 7-like 2 isoform X11

  19. XM_040702247.2 → XP_040558181.1  transcription factor 7-like 2 isoform X12

    Conserved Domains (1) summary
    cd01388
    Location:296 → 363
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

  20. XM_015288570.4 → XP_015144056.1  transcription factor 7-like 2 isoform X31

    UniProtKB/TrEMBL
    A0A8V0Z7W8
    Related
    ENSGALP00010027257.1, ENSGALT00010045726.1
    Conserved Domains (2) summary
    cd01388
    Location:296 → 363
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam08347
    Location:17 → 202
    CTNNB1_binding; N-terminal CTNNB1 binding

  21. XM_046942724.1 → XP_046798680.1  transcription factor 7-like 2 isoform X13

  22. XM_015288559.4 → XP_015144045.1  transcription factor 7-like 2 isoform X18

    UniProtKB/TrEMBL
    A0A8V0Z7W8
    Related
    ENSGALP00010027251.1, ENSGALT00010045717.1
    Conserved Domains (2) summary
    cd01388
    Location:335 → 402
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam08347
    Location:17 → 236
    CTNNB1_binding; N-terminal CTNNB1 binding

  23. XM_015288566.4 → XP_015144052.1  transcription factor 7-like 2 isoform X24

    UniProtKB/TrEMBL
    A0A8V0Z7W8
    Conserved Domains (2) summary
    cd01388
    Location:335 → 402
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam08347
    Location:17 → 236
    CTNNB1_binding; N-terminal CTNNB1 binding

  24. XM_015288560.4 → XP_015144046.1  transcription factor 7-like 2 isoform X18

    UniProtKB/TrEMBL
    A0A8V0Z7W8
    Conserved Domains (2) summary
    cd01388
    Location:335 → 402
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam08347
    Location:17 → 236
    CTNNB1_binding; N-terminal CTNNB1 binding

  25. XM_015288557.4 → XP_015144043.1  transcription factor 7-like 2 isoform X14

    UniProtKB/TrEMBL
    A0A8V0Z7W8
    Conserved Domains (2) summary
    cd01388
    Location:335 → 402
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam08347
    Location:17 → 236
    CTNNB1_binding; N-terminal CTNNB1 binding

  26. XM_015288564.4 → XP_015144050.1  transcription factor 7-like 2 isoform X20

    UniProtKB/TrEMBL
    A0A8V0Z7W8
    Conserved Domains (2) summary
    cd01388
    Location:335 → 402
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam08347
    Location:17 → 236
    CTNNB1_binding; N-terminal CTNNB1 binding

  27. XM_040702249.2 → XP_040558183.1  transcription factor 7-like 2 isoform X15

    UniProtKB/TrEMBL
    A0A8V0Z7W8, A0A8V0Z7X4
    Related
    ENSGALP00010027262.1, ENSGALT00010045737.1
    Conserved Domains (2) summary
    cd01388
    Location:330 → 397
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam08347
    Location:17 → 236
    CTNNB1_binding; N-terminal CTNNB1 binding

  28. XM_046942726.1 → XP_046798682.1  transcription factor 7-like 2 isoform X22

  29. XM_046942725.1 → XP_046798681.1  transcription factor 7-like 2 isoform X16

  30. XM_046942727.1 → XP_046798683.1  transcription factor 7-like 2 isoform X30

  31. XM_040702252.2 → XP_040558186.1  transcription factor 7-like 2 isoform X29

    Conserved Domains (1) summary
    cd01388
    Location:170 → 237
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

  32. XM_040702253.2 → XP_040558187.1  transcription factor 7-like 2 isoform X28

    Conserved Domains (1) summary
    cd01388
    Location:170 → 237
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052578.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    27734046..27906377
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046919854.1 → XP_046775810.1  transcription factor 7-like 2 isoform X1

  2. XM_046919855.1 → XP_046775811.1  transcription factor 7-like 2 isoform X2

  3. XM_046919870.1 → XP_046775826.1  transcription factor 7-like 2 isoform X17

    UniProtKB/TrEMBL
    A0A8V0ZFC1

  4. XM_046919860.1 → XP_046775816.1  transcription factor 7-like 2 isoform X7

  5. XM_046919859.1 → XP_046775815.1  transcription factor 7-like 2 isoform X6

  6. XM_046919877.1 → XP_046775833.1  transcription factor 7-like 2 isoform X23

  7. XM_046919857.1 → XP_046775813.1  transcription factor 7-like 2 isoform X4

    UniProtKB/TrEMBL
    A0A8V0Z7Y0

  8. XM_046919873.1 → XP_046775829.1  transcription factor 7-like 2 isoform X19

  9. XM_046919862.1 → XP_046775818.1  transcription factor 7-like 2 isoform X9

    UniProtKB/TrEMBL
    A0A8V0Z222

  10. XM_046919861.1 → XP_046775817.1  transcription factor 7-like 2 isoform X8

    UniProtKB/TrEMBL
    A0A1D5P979

  11. XM_046919880.1 → XP_046775836.1  transcription factor 7-like 2 isoform X26

    UniProtKB/TrEMBL
    A0A8V0Z8F7

  12. XM_046919856.1 → XP_046775812.1  transcription factor 7-like 2 isoform X3

  13. XM_046919879.1 → XP_046775835.1  transcription factor 7-like 2 isoform X25

  14. XM_046919858.1 → XP_046775814.1  transcription factor 7-like 2 isoform X5

  15. XM_046919875.1 → XP_046775831.1  transcription factor 7-like 2 isoform X21

  16. XM_046919863.1 → XP_046775819.1  transcription factor 7-like 2 isoform X10

  17. XM_046919881.1 → XP_046775837.1  transcription factor 7-like 2 isoform X27

  18. XM_046919864.1 → XP_046775820.1  transcription factor 7-like 2 isoform X11

  19. XM_046919865.1 → XP_046775821.1  transcription factor 7-like 2 isoform X12

  20. XM_046919885.1 → XP_046775841.1  transcription factor 7-like 2 isoform X31

  21. XM_046919866.1 → XP_046775822.1  transcription factor 7-like 2 isoform X13

  22. XM_046919871.1 → XP_046775827.1  transcription factor 7-like 2 isoform X18

  23. XM_046919878.1 → XP_046775834.1  transcription factor 7-like 2 isoform X24

  24. XM_046919872.1 → XP_046775828.1  transcription factor 7-like 2 isoform X18

  25. XM_046919867.1 → XP_046775823.1  transcription factor 7-like 2 isoform X14

  26. XM_046919874.1 → XP_046775830.1  transcription factor 7-like 2 isoform X20

  27. XM_046919868.1 → XP_046775824.1  transcription factor 7-like 2 isoform X15

    UniProtKB/TrEMBL
    A0A8V0Z7X4

  28. XM_046919876.1 → XP_046775832.1  transcription factor 7-like 2 isoform X22

  29. XM_046919869.1 → XP_046775825.1  transcription factor 7-like 2 isoform X16

  30. XM_046919884.1 → XP_046775840.1  transcription factor 7-like 2 isoform X30

  31. XM_046919883.1 → XP_046775839.1  transcription factor 7-like 2 isoform X29

  32. XM_046919882.1 → XP_046775838.1  transcription factor 7-like 2 isoform X28

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Miscellaneous