CASP6 caspase 6 [Gallus gallus (chicken)] - Gene

Summary

Symbol: CASP6provided by CGNC
Full Name: caspase 6provided by CGNC
Primary source: CGNC:9250
See related: Ensembl:ENSGALG00010003879
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as: CASP-6; caspase-6
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 4

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	4	NC_052535.1 (57664611..57673424)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	4	NC_052576.1 (57667667..57676482)

Chromosome 4 - NC_052535.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CASP6 is responsible for cleaving lamin A and completion of chromosome condensation during nuclear disassembly of apoptosis
Title: Caspase-6 gene disruption reveals a requirement for lamin A cleavage in apoptotic chromatin condensation.

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables cysteine-type endopeptidase activity involved in execution phase of apoptosis	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in proteolysis	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: caspase-6

Names: caspase 6, apoptosis-related cysteine peptidase; caspase 6, apoptosis-related cysteine protease

NP_001383075.1

EC 3.4.22.59

NP_001383076.1

EC 3.4.22.59

NP_001383077.1

EC 3.4.22.59

NP_990057.2

EC 3.4.22.59

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001396146.1 → NP_001383075.1 caspase-6 isoform 2

Status: VALIDATED

Source sequence(s)

JAENSK010000074

UniProtKB/Swiss-Prot

A0A1D5PPP7, O93415

Conserved Domains (1) summary

cd00032
Location:48 → 298

CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
NM_001396147.1 → NP_001383076.1 caspase-6 isoform 3

Status: VALIDATED

Source sequence(s)

JAENSK010000074

UniProtKB/Swiss-Prot

A0A1D5PPP7, O93415

UniProtKB/TrEMBL

A0A8V0XHU9

Related

ENSGALP00010005310.1, ENSGALT00010008995.1

Conserved Domains (1) summary

cd00032
Location:32 → 250

CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
NM_001396148.1 → NP_001383077.1 caspase-6 isoform 4

Status: VALIDATED

Source sequence(s)

JAENSK010000074

UniProtKB/Swiss-Prot

A0A1D5PPP7, O93415

Conserved Domains (1) summary

cd00032
Location:31 → 249

CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
NM_204726.2 → NP_990057.2 caspase-6 isoform 1

Status: VALIDATED

Source sequence(s)

JAENSK010000074

UniProtKB/Swiss-Prot

A0A1D5PPP7, O93415

Related

ENSGALP00010005306.1, ENSGALT00010008991.1

Conserved Domains (1) summary

cd00032
Location:49 → 299

CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...