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FURIN furin, paired basic amino acid cleaving enzyme [ Gallus gallus (chicken) ]

Gene ID: 395457, updated on 5-Mar-2024

Summary

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Official Symbol
FURINprovided by CGNC
Official Full Name
furin, paired basic amino acid cleaving enzymeprovided by CGNC
Primary source
CGNC:49330
See related
Ensembl:ENSGALG00010000058
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 10
Exon count:
19
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 10 NC_052541.1 (20130038..20142558, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 10 NC_052582.1 (19994352..20006883, complement)

Chromosome 10 - NC_052541.1Genomic Context describing neighboring genes Neighboring gene mannosidase alpha class 2A member 2 Neighboring gene FES proto-oncogene, tyrosine kinase Neighboring gene microRNA mir-12218 Neighboring gene microfibrillar associated protein 1 Neighboring gene huntingtin interacting protein K

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A novel activation mechanism of avian influenza virus H9N2 by furin. Tse LV, et al. J Virol, 2014 Feb. PMID 24257604, Free PMC Article
  2. Targeted infection of endothelial cells by avian influenza virus A/FPV/Rostock/34 (H7N1) in chicken embryos. Feldmann A, et al. J Virol, 2000 Sep. PMID 10933711, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. H9N2 HA can be cleaved in cells with high levels of furin expression.
    Title: A novel activation mechanism of avian influenza virus H9N2 by furin.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in peptide hormone processing IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in trans-Golgi network IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
furin
Names
trans Golgi network protease furin
NP_001383040.1
NP_001383041.1
NP_001383042.1
NP_990046.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001396111.1 → NP_001383040.1  furin precursor

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000246
    UniProtKB/TrEMBL
    A0A8V0X4D8, F1NXT1, Q91000
    Related
    ENSGALP00010000069.1, ENSGALT00010000093.1
    Conserved Domains (5) summary
    cd04059
    Location:114 → 403
    Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
    smart00261
    Location:644 → 681
    FU; Furin-like repeats
    pfam01483
    Location:485 → 571
    P_proprotein; Proprotein convertase P-domain
    pfam14843
    Location:587 → 671
    GF_recep_IV; Growth factor receptor domain IV
    pfam16470
    Location:34 → 108
    S8_pro-domain; Peptidase S8 pro-domain

  2. NM_001396112.1 → NP_001383041.1  furin precursor

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000246
    UniProtKB/TrEMBL
    A0A8V0X4D8, F1NXT1, Q91000
    Conserved Domains (5) summary
    cd04059
    Location:114 → 403
    Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
    smart00261
    Location:644 → 681
    FU; Furin-like repeats
    pfam01483
    Location:485 → 571
    P_proprotein; Proprotein convertase P-domain
    pfam14843
    Location:587 → 671
    GF_recep_IV; Growth factor receptor domain IV
    pfam16470
    Location:34 → 108
    S8_pro-domain; Peptidase S8 pro-domain

  3. NM_001396113.1 → NP_001383042.1  furin precursor

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000246
    UniProtKB/TrEMBL
    A0A8V0X4D8, F1NXT1, Q91000
    Conserved Domains (5) summary
    cd04059
    Location:114 → 403
    Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
    smart00261
    Location:644 → 681
    FU; Furin-like repeats
    pfam01483
    Location:485 → 571
    P_proprotein; Proprotein convertase P-domain
    pfam14843
    Location:587 → 671
    GF_recep_IV; Growth factor receptor domain IV
    pfam16470
    Location:34 → 108
    S8_pro-domain; Peptidase S8 pro-domain

  4. NM_204715.2 → NP_990046.1  furin precursor

    See identical proteins and their annotated locations for NP_990046.1

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000246
    UniProtKB/TrEMBL
    A0A8V0X4D8, F1NXT1, Q91000
    Conserved Domains (5) summary
    cd04059
    Location:114 → 403
    Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
    smart00261
    Location:644 → 681
    FU; Furin-like repeats
    pfam01483
    Location:485 → 571
    P_proprotein; Proprotein convertase P-domain
    pfam14843
    Location:587 → 671
    GF_recep_IV; Growth factor receptor domain IV
    pfam16470
    Location:34 → 108
    S8_pro-domain; Peptidase S8 pro-domain

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052541.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    20130038..20142558 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052582.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    19994352..20006883 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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