RHOA ras homolog family member A [Gallus gallus (chicken)] - Gene

Summary

Symbol: RHOAprovided by CGNC
Full Name: ras homolog family member Aprovided by CGNC
Primary source: CGNC:49322
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Annotation information: Annotation category: suggests misassembly; Annotation category: partial on reference assembly
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 12

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	12	NC_052543.1 (3032030..3035006, complement)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	12	NC_052584.1 (3070957..3089353, complement)

Chromosome 12 - NC_052543.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SOX9/SOX10-NEDD9/DLC1-RHOA regulatory axis governs neural crest cell migratory polarization
Title: Asymmetric localization of DLC1 defines avian trunk neural crest polarity for directional delamination and migration.
Melanosome transfer to keratinocyte in the chicken embryonic skin is mediated by vesicle release associated with RhoA-regulated membrane blebbing.
Title: Melanosome transfer to keratinocyte in the chicken embryonic skin is mediated by vesicle release associated with Rho-regulated membrane blebbing.
RHOA-ROCK signalling is involved in establishing the right-sided sinoatrial node as the definitive pacemaker of the heart and restricts typical pacemaker gene expression to the right side of the sinus venosus myocardium.
Title: RHOA-ROCK signalling is necessary for lateralization and differentiation of the developing sinoatrial node.
Statins regulate the activation of RhoA through its isoprenylation, which is crucial for the regulation of extracellular matrix synthesis in smooth muscle cells.
Title: Effect of HMG-CoA Reductase Inhibition on Vascular Smooth Muscle Cells Extracellular Matrix Production: Role of RhoA.
Data indicate that RhoA is upregulated and activated in 7 day flow cultures.
Title: Fluid flow forces and rhoA regulate fibrous development of the atrioventricular valves.
RhoA uses other pathway than ROCK/MLC in the modulation of actin stress fibers and chondrogenesis.
Title: Inhibition of RhoA but not ROCK induces chondrogenesis of chick limb mesenchymal cells.
Data show that Rho GTPases expression at the apical portion of the lens placode occurs with the same dynamics as that of the cytoskeleton.
Title: Rho signaling pathway and apical constriction in the early lens placode.
Dia1 mRNA localizes to the perinuclear endoplasmic reticulum through interactions between Dia1 nascent peptide and Rho-GTP.
Title: An RNA-zipcode-independent mechanism that localizes Dia1 mRNA to the perinuclear ER through interactions between Dia1 nascent peptide and Rho-GTP.
Results demonstrate that RhoA-mediated modulation of actin polymerization regulates the ability of Sox9 to both activate chondrocyte-specific markers and maintain its own expression in chondrocytes via a positive feedback loop.
Title: The transcriptional activity of Sox9 in chondrocytes is regulated by RhoA signaling and actin polymerization.
Data suggest that RhoA and microtubule dynamics control cell-basement membrane interaction in epithelial-mesenchymal transition during gastrulation.
Title: RhoA and microtubule dynamics control cell-basement membrane interaction in EMT during gastrulation.

Submit: New GeneRIF Correction See all GeneRIFs (16)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables GTP binding	IEA Inferred from Electronic Annotation more info	PubMed
enables GTPase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in cell migration	IEA Inferred from Electronic Annotation more info	PubMed
involved_in small GTPase-mediated signal transduction	IEA Inferred from Electronic Annotation more info	PubMed
involved_in stress fiber assembly	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cleavage furrow	IEA Inferred from Electronic Annotation more info	PubMed
located_in dendritic spine	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: transforming protein RhoA

Names: RhoA GTPase; ras homolog gene family, member A

NP_990035.1

EC 3.6.5.2

XP_046781954.1

EC 3.6.5.2

XP_046781955.1

EC 3.6.5.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_204704.2 → NP_990035.1 transforming protein RhoA

See identical proteins and their annotated locations for NP_990035.1

Status: VALIDATED

Source sequence(s)

JAENSL010000148

UniProtKB/TrEMBL

A0A8V1AC43, F1NLM4, O93467

Conserved Domains (1) summary

cd01870
Location:5 → 179

RhoA_like; Ras homology family A (RhoA)-like includes RhoA, RhoB and RhoC

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

NC_052543.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Range

3032030..3035006 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

NC_052584.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Range

3070957..3089353 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_046925998.1 → XP_046781954.1 transforming protein RhoA isoform X1
XM_046925999.1 → XP_046781955.1 transforming protein RhoA isoform X2

UniProtKB/TrEMBL

F1NLM4, O93467