U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

WNT3A Wnt family member 3A [ Gallus gallus (chicken) ]

Gene ID: 395396, updated on 3-Apr-2024

Summary

Go to the top of the page Help
Symbol
WNT3Aprovided by CGNC
Full Name
Wnt family member 3Aprovided by CGNC
Primary source
CGNC:49296
See related
Ensembl:ENSGALG00010026141
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
WNT-3A
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
chromosome: 2
Exon count:
6
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 2 NC_052533.1 (2481342..2572222, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 2 NC_052574.1 (2485428..2576246, complement)

Chromosome 2 - NC_052533.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC121109710 Neighboring gene uncharacterized LOC121109711 Neighboring gene microRNA 6713 Neighboring gene uncharacterized LOC107052482 Neighboring gene Wnt family member 9A Neighboring gene uncharacterized LOC121109942 Neighboring gene uncharacterized LOC121109943

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. A soluble and active form of Wnt-3a protein is involved in myogenic differentiation after cholesterol depletion. Portilho DM, et al. FEBS Lett, 2007 Dec 22. PMID 18037380
  2. A Wnt3a variant participates in chick apical ectodermal ridge formation: distinct biological activities of Wnt3a splice variants in chick limb development. Narita T, et al. Dev Growth Differ, 2007 Aug. PMID 17488271
  3. Early temporal-specific responses and differential sensitivity to lithium and Wnt-3A exposure during heart development. Manisastry SM, et al. Dev Dyn, 2006 Aug. PMID 16804895
  4. A proliferative role for Wnt-3a in chick somites. Galli LM, et al. Dev Biol, 2004 May 15. PMID 15110715
  5. Forced activation of Wnt signaling alters morphogenesis and sensory organ identity in the chicken inner ear. Stevens CB, et al. Dev Biol, 2003 Sep 1. PMID 12941626

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. results identify FZD10 as a receptor for WNT1 and WNT3A in the developing chick spinal cord.
    Title: Frizzled10 mediates WNT1 and WNT3A signaling in the dorsal spinal cord of the developing chick embryo.
  2. SMAD1 has a role in migration of cardiac progenitor cells by integrating BMP2 and Wnt3a signals
    Title: Smad1 transcription factor integrates BMP2 and Wnt3a signals in migrating cardiac progenitor cells.
  3. also enhances FGF8 activity while inhibiting BMP5 and WNT3a signaling
    Title: Extracellular matrix protein anosmin promotes neural crest formation and regulates FGF, BMP, and WNT activities.
  4. Data show that Wnt-3 and Wnt-3a play different roles in neural crest lineages derived from different axial level of neural tube.
    Title: Wnt-3 and Wnt-3a play different region-specific roles in neural crest development in avians.
  5. These results identify Wif-1 as a novel extracellular Wnt modulator in cartilage biology.
    Title: Wif-1 is expressed at cartilage-mesenchyme interfaces and impedes Wnt3a-mediated inhibition of chondrogenesis.
  6. WNT3A up-regulates WNT/CTNNB1 signaling and regulates FGF signaling during embryonic limb development
    Title: WNT signals control FGF-dependent limb initiation and AER induction in the chick embryo.
  7. Studied Wnt3a expression patterns in chick embryo nervous system
    Title: Wnt expression patterns in chick embryo nervous system.
  8. Cardiac progenitors migrate in highly directed trajectories, which can be controlled by Wnt3a. Ectopic Wnt3a altered movement trajectories and caused cardia bifida. This was rescued by electroporation of DN-Wnt3a into prospective cardiac cells.
    Title: Wnt3a-mediated chemorepulsion controls movement patterns of cardiac progenitors and requires RhoA function.
  9. Wnt-3a is involved in the myogenic induction observed after cholesterol depletion.
    Title: A soluble and active form of Wnt-3a protein is involved in myogenic differentiation after cholesterol depletion.
  10. Alternatively spliced Wnt3a variant 2 transcript is an active form of chick Wnt3a that regulates formation of the apical ectodermal ridge.
    Title: A Wnt3a variant participates in chick apical ectodermal ridge formation: distinct biological activities of Wnt3a splice variants in chick limb development.
Submit: New GeneRIF Correction See all GeneRIFs (12)

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables cytokine activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables frizzled binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in canonical Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell fate commitment IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in multicellular organism development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in neuron differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
protein Wnt-3a
Names
Protein Wnt
Wnt-3a homolog
wingless-type MMTV integration site family member 3a
wingless-type MMTV integration site family, member 3A

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001171601.3 → NP_001165072.1  protein Wnt-3a isoform 1 precursor

    See identical proteins and their annotated locations for NP_001165072.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the shorter protein (isoform 1).
    Source sequence(s)
    JAENSK010000035
    UniProtKB/Swiss-Prot
    Q2LMP1, Q9PWH1
    UniProtKB/TrEMBL
    A0A8V1A7U9
    Related
    ENSGALP00010039302.1, ENSGALT00010063681.1
    Conserved Domains (1) summary
    cd19335
    Location:39 → 352
    Wnt_Wnt3_Wnt3a; Wnt domain found in proto-oncogene Wnt-3 and similar proteins

  2. NM_001398207.1 → NP_001385136.1  protein Wnt-3a isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000035
    Related
    ENSGALP00010039305.1, ENSGALT00010063687.1

  3. NM_001398208.1 → NP_001385137.1  protein Wnt-3a isoform 4

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000035
    Conserved Domains (1) summary
    cd19335
    Location:1 → 290
    Wnt_Wnt3_Wnt3a; Wnt domain found in proto-oncogene Wnt-3 and similar proteins

  4. NM_204675.4 → NP_990006.3  protein Wnt-3a isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding region compared to variant 1. This difference causes translation initiation at an upstream AUG and results in a protein (isoform 2) with a longer and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    JAENSK010000035
    UniProtKB/TrEMBL
    A0A8V1A7V3
    Related
    ENSGALP00010039304.1, ENSGALT00010063685.1

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052533.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    2481342..2572222 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052574.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    2485428..2576246 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q2LMP1.1 GenPept UniProtKB/Swiss-Prot:Q2LMP1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Miscellaneous