MMP9 matrix metallopeptidase 9 [Gallus gallus (chicken)] - Gene

Summary

Symbol: MMP9provided by CGNC
Full Name: matrix metallopeptidase 9provided by CGNC
Primary source: CGNC:49293
See related: Ensembl:ENSGALG00010015061
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 20

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	20	NC_052551.1 (10914732..10918856)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	20	NC_052592.1 (10702176..10706300)

Chromosome 20 - NC_052551.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Enhanced MMP-2, MMP-9 and TNF-alpha production in progressive phase correlated with sciatic nerve pathology in C. jejuni-induced Guillain-Barre syndrome in chicken model.
Title: Matrix metalloproteinases-2 and -9 in Campylobacter jejuni-induced paralytic neuropathy resembling Guillain-Barré syndrome in chickens.
metalloproteinase-9 increased as a result of glucocorticoid-stimulation in vitro. Findings indicate that excess prenatal glucocorticoid stimulation disturbs normal development of the cerebellum through mechanisms associated with reduced proliferation and accelerated maturation where PAX6 and metalloproteinase-9 play important roles.
Title: Glucocorticoid Effects on Cerebellar Development in a Chicken Embryo Model: Exploring Changes in PAX6 and Metalloproteinase-9 After Exposure to Dexamethasone.
Real-time polymerase chain reaction and western blot revealed different expression of MMP-2, -7, -9 and TIMP-2 and -3 on mRNA and protein levels, respectively, as well as activity of MMP-2 and -9 by activity assay in the oviduct parts.
Title: Involvement of matrix metalloproteinases (MMP-2, -7, -9) and their tissue inhibitors (TIMP-2, -3) in the chicken oviduct regression and recrudescence.
Protein level of MMP-9 was diminished, while MMP-7 and TIMP-3 were elevated in the oviduct of growing birds. MMP-2 and TIMP-2 protein levels remained constant, with a slight increase in MMP-2 concentration just before reaching maturity.
Title: Expression and localization of matrix metalloproteinases (MMP-2, -7, -9) and their tissue inhibitors (TIMP-2, -3) in the chicken oviduct during maturation.
Type I collagen promotes the expression and activation of MMPs in a lens epithelial cell-specific manner.
Title: Type I collagen accelerates the spreading of lens epithelial cells through the expression and activation of matrix metalloproteinases.
MMP9 is a novel effector which is required for neural crest cells delamination and migration.
Title: Matrix metalloproteinase 9/gelatinase B is required for neural crest cell migration.
results suggest that elevated levels of sPLA2 secreted by wing bud mesenchymal cells promote type I collagen degradation by MMP-9 in a manner typical of receptor-mediated signalling and that these events lead to cell death.
Title: Secretory phospholipase A2 promotes MMP-9-mediated cell death by degrading type I collagen via the ERK pathway at an early stage of chondrogenesis.
plays a role in the vascularization and ossification processes
Title: Expression of matrix metalloproteinases during vascularization and ossification of normal and impaired avian growth plate.
upregulation of the avian 75-kDa gelatinase B-like enzyme by vitamins A and D, coupled with its perivascular expression pattern in the growth plate, implies a similar role for the mammalian and avian genes in bone formation
Title: Expression of chicken 75-kDa gelatinase B-like enzyme in perivascular chondrocytes suggests its role in vascularization of the growth plate.
It is suggested that MMP-2 and MMP-9 enzymes might play a role in the permeability increase of vessel walls by the destruction of the basement membranes in the salt-induced experimental ascites syndrome in broiler chickens
Title: The identification of matrix metalloproteinases and their tissue inhibitors in broiler chickens by immunohistochemistry.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables metalloendopeptidase activity	IEA Inferred from Electronic Annotation more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in collagen catabolic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in extracellular matrix organization	IEA Inferred from Electronic Annotation more info	PubMed
involved_in proteolysis	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular matrix	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: matrix metalloproteinase-9

Names: 75 kDa gelatinase; matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase); matrix metalloproteinase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)

NP_989998.2

EC 3.4.24.35

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_204667.2 → NP_989998.2 matrix metalloproteinase-9 precursor

Status: VALIDATED

Source sequence(s)

JAENSK010000328

UniProtKB/TrEMBL

A0A8V0YXL9, Q9DE15

Related

ENSGALP00010021072.1, ENSGALT00010036247.1

Conserved Domains (3) summary

smart00059
Location:341 → 389

FN2; Fibronectin type 2 domain

cd00094
Location:497 → 685

HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...

cd04278
Location:117 → 445

ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...