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BCO1 beta-carotene oxygenase 1 [ Gallus gallus (chicken) ]

Gene ID: 395346, updated on 5-Mar-2024

Summary

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Symbol
BCO1provided by CGNC
Full Name
beta-carotene oxygenase 1provided by CGNC
Primary source
CGNC:4027
See related
Ensembl:ENSGALG00010007880
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
BCDO; BCMO1
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 11
Exon count:
12
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 11 NC_052542.1 (15103292..15117240)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 11 NC_052583.1 (15450598..15464558)

Chromosome 11 - NC_052542.1Genomic Context describing neighboring genes Neighboring gene glycine cleavage system protein H Neighboring gene polycystin 1 like 2 Neighboring gene gigaxonin Neighboring gene uncharacterized LOC121111713 Neighboring gene c-Maf inducing protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Beta-carotene preferentially regulates chicken myoblast proliferation withdrawal and differentiation commitment via BCO1 activity and retinoic acid production. Praud C, et al. Exp Cell Res, 2017 Sep 15. PMID 28625776
  2. Nutrigenetics of carotenoid metabolism in the chicken: a polymorphism at the β,β-carotene 15,15'-mono-oxygenase 1 (BCMO1) locus affects the response to dietary β-carotene. Jlali M, et al. Br J Nutr, 2014 Jun 28. PMID 24642187
  3. A mutation in the promoter of the chicken β,β-carotene 15,15'-monooxygenase 1 gene alters xanthophyll metabolism through a selective effect on its mRNA abundance in the breast muscle. Jlali M, et al. J Anim Sci, 2012 Dec. PMID 23125440
  4. Developmental changes in gene expressions of beta-carotene cleavage enzyme and retinoic acid synthesizing enzymes in the chick duodenum. Yamaguchi N, et al. Comp Biochem Physiol A Mol Integr Physiol, 2007 Nov. PMID 17890117
  5. Feedback regulation of beta,beta-carotene 15,15'-monooxygenase by retinoic acid in rats and chickens. Bachmann H, et al. J Nutr, 2002 Dec. PMID 12468597

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. observed that in myoblast showing decreased BCO1 expression consecutive to a natural mutation or to a siRNA treatment
    Title: Beta-carotene preferentially regulates chicken myoblast proliferation withdrawal and differentiation commitment via BCO1 activity and retinoic acid production.
  2. genetic association study in domestic chickens in France: Data suggest that two SNPs in BCMO1 promoter are associated with higher absorption of dietary beta-carotene in duodenum and reduced absorption of xanthophylls/liposoluble vitamins/cholesterol.
    Title: Nutrigenetics of carotenoid metabolism in the chicken: a polymorphism at the β,β-carotene 15,15'-mono-oxygenase 1 (BCMO1) locus affects the response to dietary β-carotene.
  3. These results indicated that a genetic variant of BCMO1 specifically changes lutein and zeaxanthin content in the chicken plasma and breast muscle without impairing vitamin A and E metabolism.
    Title: A mutation in the promoter of the chicken β,β-carotene 15,15'-monooxygenase 1 gene alters xanthophyll metabolism through a selective effect on its mRNA abundance in the breast muscle.
  4. Data indicate taht two fully-linked single nucleotide polymorphisms (SNP) located within the proximal promoter of BCMO1 gene were identified.
    Title: Detection of a Cis [corrected] eQTL controlling BCMO1 gene expression leads to the identification of a QTG for chicken breast meat color.
  5. Postnatal induction of BCMO1 gene expression in the chick duodenum may be caused by the elevation of serum hydrocortisone levels and may contribute to the RALDH1-mediated retinoic acid synthetic pathway.
    Title: Developmental changes in gene expressions of beta-carotene cleavage enzyme and retinoic acid synthesizing enzymes in the chick duodenum.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables beta-carotene 15,15'-dioxygenase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables carotenoid dioxygenase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in carotene catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in retinal metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
beta,beta-carotene 15,15'-dioxygenase
Names
beta,beta-carotene 15,15'-monooxygenase
beta-carotene 15,15'-dioxygenase
beta-carotene 15,15'-monooxygenase 1
beta-carotene dioxygenase 1
NP_001351831.1
NP_001384065.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001364902.2 → NP_001351831.1  beta,beta-carotene 15,15'-dioxygenase

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000248
    UniProtKB/Swiss-Prot
    Q9I993
    Related
    ENSGALP00010010301.1, ENSGALT00010018751.1
    Conserved Domains (1) summary
    pfam03055
    Location:10 → 517
    RPE65; Retinal pigment epithelial membrane protein

  2. NM_001397136.1 → NP_001384065.1  beta,beta-carotene 15,15'-dioxygenase

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000248
    UniProtKB/Swiss-Prot
    Q9I993
    Conserved Domains (1) summary
    pfam03055
    Location:10 → 517
    RPE65; Retinal pigment epithelial membrane protein

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052542.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    15103292..15117240
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052583.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    15450598..15464558
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_204635.1: Suppressed sequence

    Description
    NM_204635.1: This RefSeq was removed because currently there is insufficient support for the 5'' end of the transcript.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9I993.1 GenPept UniProtKB/Swiss-Prot:Q9I993

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.