KDR kinase insert domain receptor [Gallus gallus (chicken)] - Gene

Summary

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Symbol: KDRprovided by CGNC
Full Name: kinase insert domain receptorprovided by CGNC
Primary source: CGNC:10404
See related: Ensembl:ENSGALG00010013498
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as: FLK1; VEGFR2
Orthologs: human mouse all
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Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	4	NC_052535.1 (64703991..64731765)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	4	NC_052576.1 (64687092..64714942)

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The VEGF and VEGFR-2 genes play critical roles in feather maturity. In addition, VEGFR-2 exon10-A69G and genotype EF in the Princess chicken could potentially be utilised as genetic markers to improve efficiency in breeding.
Title: Genetic effects of vascular endothelial growth factor and its receptor 2 on feather maturity in three chicken breeds.
VEGF-A and VEGF-R2 mRNA was decreased in cadmium treated extraembryonic membranes.
Title: Exposure of chick embryos to cadmium changes the extra-embryonic vascular branching pattern and alters expression of VEGF-A and VEGF-R2.
Vascular endothelial growth factor receptor 2 (VEGFR2) interacted with peptide Lv.
Title: Peptide Lv augments L-type voltage-gated calcium channels through vascular endothelial growth factor receptor 2 (VEGFR2) signaling.
The impact of embryonic hypoxia on hypoxia inducible factor 2alpha(HIF-2alpha), VEGF, and its type 2 receptor in 6- and 7-day-old chick embryos are reprorted.
Title: Vascular density, hypoxia inducible factor, vascular endothelial growth factor, and its receptor expression in the chorioallantois of relatively normoxic and hypoxic chicken embryos, at 6 and 7 days of incubation, and corresponding weight values.

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General gene information

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Markers

Kdr (e-PCR), detects polymorphism
- UniSTS:498724

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info	PubMed
enables growth factor binding	IEA Inferred from Electronic Annotation more info	PubMed
enables vascular endothelial growth factor receptor activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in angiogenesis	IEA Inferred from Electronic Annotation more info	PubMed
involved_in cell migration	IEA Inferred from Electronic Annotation more info	PubMed
involved_in endothelial cell differentiation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in multicellular organism development	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of angiogenesis	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of kinase activity	IEA Inferred from Electronic Annotation more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in vascular endothelial growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info	PubMed
part_of receptor complex	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: vascular endothelial growth factor receptor 2

Names: flk-1 receptor; kinase insert domain receptor (a type III receptor tyrosine kinase); protein-tyrosine kinase

NP_001004368.2

EC 2.7.1.112

EC 2.7.10.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001004368.2 → NP_001004368.2 vascular endothelial growth factor receptor 2 precursor

Status: PROVISIONAL

Source sequence(s)

JAENSK010000074

UniProtKB/TrEMBL

F1NW21, Q677M1

Related

ENSGALP00010019244.1, ENSGALT00010032502.1

Conserved Domains (4) summary

smart00409
Location:665 → 745

IG; Immunoglobulin

smart00410
Location:547 → 652

IG_like; Immunoglobulin like

cd05103
Location:817 → 1160

PTKc_VEGFR2; Catalytic domain of the Protein Tyrosine Kinase, Vascular Endothelial Growth Factor Receptor 2

pfam17988
Location:750 → 784

VEGFR-2_TMD; VEGFR-2 Transmembrane domain