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F2 coagulation factor II, thrombin [ Gallus gallus (chicken) ]

Gene ID: 395306, updated on 5-Mar-2024

Summary

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Official Symbol
F2provided by CGNC
Official Full Name
coagulation factor II, thrombinprovided by CGNC
Primary source
CGNC:6314
See related
Ensembl:ENSGALG00010022987
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
prothrombin
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 5
Exon count:
14
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 5 NC_052536.1 (22969085..22978711, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 5 NC_052577.1 (22936622..22946548, complement)

Chromosome 5 - NC_052536.1Genomic Context describing neighboring genes Neighboring gene LDL receptor related protein 4 Neighboring gene cytoskeleton associated protein 5 Neighboring gene small nucleolar RNA SNORD67 Neighboring gene Rho GTPase activating protein 1 Neighboring gene autophagy related 13 Neighboring gene harbinger transposase derived 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Atypical erythrocytes and platelets in a patient with a pro-thrombin mutation. Pretorius E, et al. Platelets, 2014. PMID 24175578, Free PMC Article
  2. Thrombin induces neoangiogenesis in the chick chorioallantoic membrane. Caunt M, et al. J Thromb Haemost, 2003 Oct. PMID 14521590
  3. Evolution of prothrombin: isolation and characterization of the cDNAs encoding chicken and hagfish prothrombin. Banfield DK, et al. J Mol Evol, 1994 Feb. PMID 7513365
  4. Thrombin and its protease-activated receptor-1 (PAR1) participate in the endothelial-mesenchymal transdifferentiation process. Archiniegas E, et al. DNA Cell Biol, 2004 Dec. PMID 15684708
  5. Thrombin generates previously unidentified C5 products that support the terminal complement activation pathway. Krisinger MJ, et al. Blood, 2012 Aug 23. PMID 22802338

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Atypical erythrocytes and platelets in a patient with a pro-thrombin mutation.
    Title: Atypical erythrocytes and platelets in a patient with a pro-thrombin mutation.
  2. Thrombin mediates hemolytic activity as modulated by C5 convertase.
    Title: Thrombin generates previously unidentified C5 products that support the terminal complement activation pathway.
  3. Thrombin induces neoangiogenesis in the chick chorioallantoic membrane
    Title: Thrombin induces neoangiogenesis in the chick chorioallantoic membrane.
  4. thrombin and PAR1 are involved in the remodeling of the aortic wall and intimal thickening formation, and in the endothelial-mesenchymal transdifferentiation process
    Title: Thrombin and its protease-activated receptor-1 (PAR1) participate in the endothelial-mesenchymal transdifferentiation process.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in blood coagulation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in platelet activation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of blood coagulation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in collagen-containing extracellular matrix IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
prothrombin
Names
thrombin
NP_989936.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_204605.2 → NP_989936.2  prothrombin precursor

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000214
    UniProtKB/TrEMBL
    Q91001
    Related
    ENSGALP00010033864.1, ENSGALT00010055957.1
    Conserved Domains (3) summary
    smart00069
    Location:25 → 89
    GLA; Domain containing Gla (gamma-carboxyglutamate) residues
    smart00130
    Location:107 → 187
    KR; Kringle domain
    cd00190
    Location:351 → 602
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052536.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    22969085..22978711 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052577.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    22936622..22946548 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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