U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

SP1 Sp1 transcription factor [ Gallus gallus (chicken) ]

Gene ID: 395303, updated on 3-Apr-2024

Summary

Go to the top of the page Help
Symbol
SP1provided by CGNC
Full Name
Sp1 transcription factorprovided by CGNC
Primary source
CGNC:49253
See related
Ensembl:ENSGALG00010024351
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
chromosome: 34
Exon count:
7
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 34 NC_052565.1 (1056515..1072469, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 34 NC_052606.1 (1000624..1016507, complement)

Chromosome 34 - NC_052565.1Genomic Context describing neighboring genes Neighboring gene poly(rC) binding protein 2 Neighboring gene anti-Mullerian hormone receptor type 2 Neighboring gene formin-like protein 16 Neighboring gene Sp7 transcription factor

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. v-Jun downregulates the alpha 2 (I) collagen target gene indirectly through Sp1/3. Chamboredon S, et al. Oncogene, 2005 Apr 7. PMID 15735704
  2. v-Jun downregulates the SPARC target gene by binding to the proximal promoter indirectly through Sp1/3. Chamboredon S, et al. Oncogene, 2003 Jun 26. PMID 12821939
  3. Sp1 and Sp3 regulate transcription of the chicken GAS41 gene. Hübner K, et al. Biochim Biophys Acta, 2010 May-Jun. PMID 20153453
  4. SP3/SP1 transcription activity regulates specific expression of collagen type X in hypertrophic chondrocytes. Magee C, et al. J Biol Chem, 2005 Jul 8. PMID 15849196
  5. In vivo binding of Orc2 to a region of the chicken lysozyme GAS41 origin containing multiple Sp1-binding sites. Hübner K, et al. DNA Cell Biol, 2012 Feb. PMID 21879882

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Sp1 participates in recruiting Orc2 to the origin of lysozyme GAS41.
    Title: In vivo binding of Orc2 to a region of the chicken lysozyme GAS41 origin containing multiple Sp1-binding sites.
  2. localized the GAS41 promoter close to the 3' end of the lysozyme gene and found that Sp1 and Sp3 bind to this promoter
    Title: Sp1 and Sp3 regulate transcription of the chicken GAS41 gene.
  3. activation and repression of FGFR1 gene transcription is governed by interplay between Sp1, p107, p130, and E2F4 in distinct transcriptional complexes during skeletal muscle development
    Title: Dynamic transcriptional regulatory complexes, including E2F4, p107, p130, and Sp1, control fibroblast growth factor receptor 1 gene expression during myogenesis.
  4. the SP3/SP1 ratio and Dlx5 are important regulators of the proximal Col10a1 promoter in hypertrophic cartilage
    Title: SP3/SP1 transcription activity regulates specific expression of collagen type X in hypertrophic chondrocytes.
Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
transcription factor Sp1
Names
transcription factor

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_204604.2 → NP_989935.1  transcription factor Sp1

    See identical proteins and their annotated locations for NP_989935.1

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000489
    UniProtKB/TrEMBL
    A0A1D5PG84, A0A8V1A4P4, Q90WR9
    Related
    ENSGALP00010036272.1, ENSGALT00010059406.1
    Conserved Domains (4) summary
    sd00017
    Location:601 → 623
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:659 → 681
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:645 → 668
    zf-H2C2_2; Zinc-finger double domain
    cd22539
    Location:32 → 600
    SP1_N; N-terminal domain of transcription factor Specificity Protein (SP) 1

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052565.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    1056515..1072469 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015300324.4 → XP_015155810.1  transcription factor Sp1 isoform X1

    UniProtKB/TrEMBL
    A0A8V1A4P4
    Related
    ENSGALP00010036278.1, ENSGALT00010059415.1
    Conserved Domains (3) summary
    sd00017
    Location:592 → 614
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:650 → 672
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:636 → 659
    zf-H2C2_2; Zinc-finger double domain

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052606.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    1000624..1016507 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046934178.1 → XP_046790134.1  transcription factor Sp1 isoform X1

Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.