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GJA1 gap junction protein alpha 1 [ Gallus gallus (chicken) ]

Gene ID: 395278, updated on 3-Apr-2024

Summary

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Symbol
GJA1provided by CGNC
Full Name
gap junction protein alpha 1provided by CGNC
Primary source
CGNC:11038
See related
Ensembl:ENSGALG00010012939
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
CX43; connexin-43
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 3
Exon count:
3
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 3 NC_052534.1 (61409929..61419060, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 3 NC_052575.1 (61320528..61329663, complement)

Chromosome 3 - NC_052534.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107053071 Neighboring gene uncharacterized LOC107053072 Neighboring gene uncharacterized LOC107053073 Neighboring gene TBC1 domain family member 32

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Calcium oscillations coordinate feather mesenchymal cell movement by SHH dependent modulation of gap junction networks. Li A, et al. Nat Commun, 2018 Dec 18. PMID 30560870, Free PMC Article
  2. Polymorphisms in GJA1 and their association with growth traits in chicken. Shahjahan M, et al. Genet Mol Res, 2015 Dec 29. PMID 26782534
  3. Hormonal, pH, and calcium regulation of connexin 43-mediated dye transfer in osteocytes in chick calvaria. Ishihara Y, et al. J Bone Miner Res, 2008 Mar. PMID 17997713
  4. Differential expression of connexin 43 in the chick tangential vestibular nucleus. Popratiloff A, et al. J Neurosci Res, 2003 Mar 1. PMID 12584721
  5. The highly conserved Gln49 and Ser50 of mammalian connexin43 are present in chick connexin43 and essential for functional gap junction channels. Sokolova IV, et al. Cell Commun Adhes, 2002 Mar-Apr. PMID 12487409

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Functional disruption experiments in chicken embryos and promoter analysis implicate synergistic Hedgehog and WNT/beta-Catenin signaling in activating Connexin-43 expression, establishing gap junction networks synchronizing the Ca2+ profile among cells, thereby coordinating cell movement patterns during feather bud elongation.
    Title: Calcium oscillations coordinate feather mesenchymal cell movement by SHH dependent modulation of gap junction networks.
  2. The present study describes four previously unknown SNPs, four haplotypes from two variants having high linkage disequilibrium, and seven diplotypes of the chicken GJA1 gene, and reports their significant association with growth traits.
    Title: Polymorphisms in GJA1 and their association with growth traits in chicken.
  3. that Cx43-hemichannel activity associated with PGE(2) release is adaptively regulated by mechanical loading to provide an effective means of regulating levels of extracellular signaling molecules responsible for initiation of bone (re)modeling.
    Title: Adaptation of connexin 43-hemichannel prostaglandin release to mechanical loading.
  4. Cell-cell communication among osteocytes in chick calvaria was mediated by Cx43 and was regulated by extracellular pH, extracellular calcium ion concentration, and PTH.
    Title: Hormonal, pH, and calcium regulation of connexin 43-mediated dye transfer in osteocytes in chick calvaria.
  5. Four percent of tenocytes had colocalization of actin filaments and Cx43, which was significantly increased with 5% cyclic strain
    Title: Connexin 43 is localized with actin in tenocytes.
  6. mechanotransduction occurs in individual cells but integration of signals markedly enhances it and (ii) communication via connexin 43 is inhibitory.
    Title: Connexin 32 and 43 gap junctions differentially modulate tenocyte response to cyclic mechanical load.
  7. fluid flow shear stress induces the translocation of Cx43 to the membrane surface and unapposed hemichannels formed by Cx43 serve as a novel portal for the release of PGE2 in response to mechanical strain
    Title: Mechanical strain opens connexin 43 hemichannels in osteocytes: a novel mechanism for the release of prostaglandin.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell-cell signaling IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in heart development IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of connexin complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
gap junction alpha-1 protein
Names
connexin 43

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_204586.3 → NP_989917.2  gap junction alpha-1 protein

    Status: PROVISIONAL

    Source sequence(s)
    JAENSK010000063
    UniProtKB/Swiss-Prot
    P14154, Q90ZE0
    UniProtKB/TrEMBL
    F1N9K3
    Related
    ENSGALP00010018062.1, ENSGALT00010031065.1
    Conserved Domains (2) summary
    smart00037
    Location:43 → 76
    CNX; Connexin homologues
    smart01089
    Location:165 → 231
    Connexin_CCC; Gap junction channel protein cysteine-rich domain

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052534.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    61409929..61419060 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046938411.1 → XP_046794367.1  gap junction alpha-1 protein isoform X1

    UniProtKB/TrEMBL
    F1N9K3
    Related
    ENSGALP00010018071.1, ENSGALT00010031076.1

  2. XM_046938410.1 → XP_046794366.1  gap junction alpha-1 protein isoform X1

    UniProtKB/TrEMBL
    F1N9K3
    Related
    ENSGALP00010018053.1, ENSGALT00010031054.1

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052575.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    61320528..61329663 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046912937.1 → XP_046768893.1  gap junction alpha-1 protein isoform X1

    UniProtKB/TrEMBL
    F1N9K3

  2. XM_046912935.1 → XP_046768891.1  gap junction alpha-1 protein isoform X1

    UniProtKB/TrEMBL
    F1N9K3

  3. XM_046912936.1 → XP_046768892.1  gap junction alpha-1 protein isoform X1

    UniProtKB/TrEMBL
    F1N9K3
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P14154.3 GenPept UniProtKB/Swiss-Prot:P14154

Gene LinkOut

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