FAS Fas cell surface death receptor [Gallus gallus (chicken)] - Gene

Summary

Symbol: FASprovided by CGNC
Full Name: Fas cell surface death receptorprovided by CGNC
Primary source: CGNC:4779
See related: Ensembl:ENSGALG00010022081
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 6

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	6	NC_052537.1 (20018484..20030805)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	6	NC_052578.1 (20005428..20017749)

Chromosome 6 - NC_052537.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

FAS from the extrinsic apoptosis pathway and BAK1 from the intrinsic apoptosis pathway shows higher fold downregulation in EGK.X blastoderms and primordial germ cells compared to chicken embryonic fibroblasts.
Title: Chicken blastoderms and primordial germ cells possess a higher expression of DNA repair genes and lower expression of apoptosis genes to preserve their genome stability.
The results showed that there were significant (P < 0.05) genotypic differences between dead and normally developing embryos for the FAS gene polymorphism, a SNP in exon 3 (NC_006093.2:g.6514A>C, rs15793179).
Title: The effects of the polymorphism in exon 3 of the FAS gene on the death of chicken embryos during the incubation period.
Blocking the Fas-FasL signaling pathway could be considered as a method for preventing secondary degeneration of SGNs.
Title: Secondary apoptosis of spiral ganglion cells induced by aminoglycoside: Fas-Fas ligand signaling pathway.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables protein binding	IEA Inferred from Electronic Annotation more info	PubMed
enables tumor necrosis factor receptor activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in activation-induced cell death of T cells	IEA Inferred from Electronic Annotation more info	PubMed
involved_in extrinsic apoptotic signaling pathway in absence of ligand	IEA Inferred from Electronic Annotation more info	PubMed
involved_in immune response	IEA Inferred from Electronic Annotation more info	PubMed
involved_in motor neuron apoptotic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in necroptotic signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in negative regulation of apoptotic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of stress-activated MAPK cascade	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
part_of CD95 death-inducing signaling complex	IEA Inferred from Electronic Annotation more info	PubMed
located_in external side of plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed
located_in membrane raft	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: tumor necrosis factor receptor superfamily member 6

Names: Fas (TNF receptor superfamily, member 6); fas antigen; fas ligand receptor soluble form

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001199487.2 → NP_001186416.2 tumor necrosis factor receptor superfamily member 6 precursor

Status: VALIDATED

Source sequence(s)

JAENSK010000231

UniProtKB/TrEMBL

A0A8V0ZU18, Q9DGH7

Related

ENSGALP00010032343.1, ENSGALT00010053693.1

Conserved Domains (3) summary

cd08316
Location:202 → 295

Death_FAS_TNFRSF6; Death domain of FAS or TNF receptor superfamily member 6

cd00185
Location:84 → 126

TNFRSF; CRD2 [structural motif]

cl22855
Location:40 → 167

TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

NC_052537.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Range

20018484..20030805

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_015288355.4 → XP_015143841.2 tumor necrosis factor receptor superfamily member 6 isoform X4

Conserved Domains (3) summary

cd08316
Location:239 → 332

Death_FAS_TNFRSF6; Death domain of FAS or TNF receptor superfamily member 6

cd00185
Location:34 → 66

TNFRSF; CRD1 [structural motif]

cl22855
Location:25 → 177

TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)
XM_015288351.4 → XP_015143837.4 tumor necrosis factor receptor superfamily member 6 isoform X1
XM_015288354.4 → XP_015143840.4 tumor necrosis factor receptor superfamily member 6 isoform X3
XM_015288353.4 → XP_015143839.4 tumor necrosis factor receptor superfamily member 6 isoform X2

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

NC_052578.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Range

20005428..20017749

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_046919846.1 → XP_046775802.1 tumor necrosis factor receptor superfamily member 6 isoform X4
XM_046919842.1 → XP_046775798.1 tumor necrosis factor receptor superfamily member 6 isoform X1
XM_046919845.1 → XP_046775801.1 tumor necrosis factor receptor superfamily member 6 isoform X3
XM_046919844.1 → XP_046775800.1 tumor necrosis factor receptor superfamily member 6 isoform X2