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CLTC clathrin heavy chain [ Gallus gallus (chicken) ]

Gene ID: 395272, updated on 3-Apr-2024

Summary

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Symbol
CLTCprovided by CGNC
Full Name
clathrin heavy chainprovided by CGNC
Primary source
CGNC:49238
See related
Ensembl:ENSGALG00010029262
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
CHC
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 19
Exon count:
33
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 19 NC_052550.1 (7761739..7791235)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 19 NC_052591.1 (7498566..7528062)

Chromosome 19 - NC_052550.1Genomic Context describing neighboring genes Neighboring gene yippee like 2 Neighboring gene microRNA 1697 Neighboring gene DEAH-box helicase 40 Neighboring gene peptidyl-tRNA hydrolase 2 Neighboring gene vacuole membrane protein 1 Neighboring gene uncharacterized LOC107054808

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cellular uptake of avian leukosis virus subgroup B is mediated by clathrin. Diaz-Griffero F, et al. Virology, 2005 Jun 20. PMID 15914219
  2. Controlled elimination of clathrin heavy-chain expression in DT40 lymphocytes. Wettey FR, et al. Science, 2002 Aug 30. PMID 12202821
  3. SDF-1 chemokine signalling modulates the apoptotic responses to iron deprivation of clathrin-depleted DT40 cells. Pance A, et al. PLoS One, 2014. PMID 25162584, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SDF-1 chemokine signaling modulates the apoptotic responses to iron deprivation of clathrin-depleted Precursor B-Cells.
    Title: SDF-1 chemokine signalling modulates the apoptotic responses to iron deprivation of clathrin-depleted DT40 cells.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables clathrin light chain binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables structural molecule activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in clathrin coat assembly IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in mitotic cell cycle IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in receptor-mediated endocytosis IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of clathrin coat of coated pit IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of clathrin coat of trans-Golgi network vesicle IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of clathrin complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in clathrin-coated endocytic vesicle IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in extracellular exosome IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in spindle IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
clathrin heavy chain 1
Names
clathrin, heavy chain (Hc)
clathrin, heavy polypeptide (Hc)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001080117.2 → NP_001073586.1  clathrin heavy chain 1

    See identical proteins and their annotated locations for NP_001073586.1

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000323
    UniProtKB/TrEMBL
    A0A8V1AJ48
    Related
    ENSGALP00010043442.1, ENSGALT00010070751.1
    Conserved Domains (6) summary
    smart00299
    Location:1274 → 1416
    CLH; Clathrin heavy chain repeat homology
    sd00006
    Location:1105 → 1131
    TPR; TPR repeat [structural motif]
    pfam00637
    Location:979 → 1119
    Clathrin; Region in Clathrin and VPS
    pfam01394
    Location:198 → 234
    Clathrin_propel; Clathrin propeller repeat
    pfam09268
    Location:331 → 354
    Clathrin-link; Clathrin, heavy-chain linker
    pfam13838
    Location:356 → 421
    Clathrin_H_link; Clathrin-H-link

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052550.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    7761739..7791235
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015295663.4 → XP_015151149.1  clathrin heavy chain 1 isoform X1

    UniProtKB/TrEMBL
    A0A8V1ABS2, A0A8V1AL87
    Related
    ENSGALP00010043443.1, ENSGALT00010070752.1
    Conserved Domains (6) summary
    smart00299
    Location:1274 → 1416
    CLH; Clathrin heavy chain repeat homology
    sd00006
    Location:1105 → 1131
    TPR; TPR repeat [structural motif]
    pfam01394
    Location:198 → 234
    Clathrin_propel; Clathrin propeller repeat
    pfam00637
    Location:1427 → 1564
    Clathrin; Region in Clathrin and VPS
    pfam09268
    Location:331 → 354
    Clathrin-link; Clathrin, heavy-chain linker
    pfam13838
    Location:356 → 421
    Clathrin_H_link; Clathrin-H-link

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052591.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    7498566..7528062
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046929896.1 → XP_046785852.1  clathrin heavy chain 1 isoform X1

    UniProtKB/TrEMBL
    A0A8V1ABS2
    Conserved Domains (6) summary
    smart00299
    Location:1274 → 1416
    CLH; Clathrin heavy chain repeat homology
    sd00006
    Location:1105 → 1131
    TPR; TPR repeat [structural motif]
    pfam01394
    Location:198 → 234
    Clathrin_propel; Clathrin propeller repeat
    pfam00637
    Location:1427 → 1564
    Clathrin; Region in Clathrin and VPS
    pfam09268
    Location:331 → 354
    Clathrin-link; Clathrin, heavy-chain linker
    pfam13838
    Location:356 → 421
    Clathrin_H_link; Clathrin-H-link
Nucleotide Protein Strain
Heading Accession and Version

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