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bru3 bruno 3 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 39527, updated on 10-May-2024

Summary

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Official Symbol
bru3provided by FlyBase
Official Full Name
bruno 3provided by FlyBase
Primary source
FLYBASE:FBgn0264001
Locus tag
Dmel_CG43744
See related
AllianceGenome:FB:FBgn0264001
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
bru-3; Bru-3; BRU-3; bruno-3; cg10046; CG10046; cg12478; CG12478; CG34243; CG43744; Dm Bru-3; Dmel\CG43744; l(3)05871
Old locus tag
Dmel_CG12478; Dmel_CG34243
Summary
Enables RNA binding activity and protein homodimerization activity. Predicted to be involved in mRNA splice site selection; negative regulation of translation; and regulation of alternative mRNA splicing, via spliceosome. Part of protein-containing complex. Is expressed in several structures, including dorsal sensory complex proper primordium; embryonic/larval nervous system; extended germ band embryo; head segment; and presumptive embryonic/larval system. Used to study myotonic dystrophy type 1. Orthologous to several human genes including CELF5 (CUGBP Elav-like family member 5). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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Location:
70B4-70C4; 3-41 cM
Exon count:
20
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (13521907..13803400, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (13515007..13796500, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Liprin-beta Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45825 Neighboring gene Vacuolar protein sorting 36 Neighboring gene long non-coding RNA:CR45178 Neighboring gene long non-coding RNA:CR45120 Neighboring gene mir-289 stem loop Neighboring gene antisense RNA:CR46266 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Bruno-3 regulates sarcomere component expression and contributes to muscle phenotypes of myotonic dystrophy type 1. Picchio L, et al. Dis Model Mech, 2018 May 21. PMID 29716962, Free PMC Article
  2. The Drosophila Bruno paralogue Bru-3 specifically binds the EDEN translational repression element. Delaunay J, et al. Nucleic Acids Res, 2004. PMID 15181172, Free PMC Article
  3. CELFish ways to modulate mRNA decay. Vlasova-St Louis I, et al. Biochim Biophys Acta, 2013 Jun-Jul. PMID 23328451, Free PMC Article
  4. The genetics of speciation by reinforcement. Ortiz-Barrientos D, et al. PLoS Biol, 2004 Dec. PMID 15550988, Free PMC Article
  5. BrunoL1 regulates endoderm proliferation through translational enhancement of cyclin A2 mRNA. Horb LD, et al. Dev Biol, 2010 Sep 15. PMID 20633547, Free PMC Article

See all (79) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. cytoplasmic Bru-3 contributes to myotonic dystrophy type 1 pathogenesis in a Drosophila model by regulating sarcomeric transcripts and protein levels.
    Title: Bruno-3 regulates sarcomere component expression and contributes to muscle phenotypes of myotonic dystrophy type 1.
  2. Drosophila Bruno paralogue, the 45 kDa Bru-3 protein (p45), binds specifically to the EDEN element and acts as a homodimer
    Title: The Drosophila Bruno paralogue Bru-3 specifically binds the EDEN translational repression element.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables RNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in mRNA splice site recognition IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of translation ISA
Inferred from Sequence Alignment
more info
 PubMed 
involved_in regulation of alternative mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of ribonucleoprotein complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
bruno 3
Names
CG43744-PA
CG43744-PB
CG43744-PC
CG43744-PD
CG43744-PE
CG43744-PF
CG43744-PG
CG43744-PH
CG43744-PI
CG43744-PJ
CG43744-PK
CG43744-PL
CG43744-PM
CG43744-PN
CG43744-PO
CG43744-PP
CG43744-PQ
CG43744-PR
bru3-PA
bru3-PB
bru3-PC
bru3-PD
bru3-PE
bru3-PF
bru3-PG
bru3-PH
bru3-PI
bru3-PJ
bru3-PK
bru3-PL
bru3-PM
bru3-PN
bru3-PO
bru3-PP
bru3-PQ
bru3-PR
bruno-3
bruno3
lethal (3) 05871

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    13521907..13803400 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001202166.4 → NP_001189095.1  bruno 3, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001189095.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    D1L6K8, M9MS36
    Conserved Domains (3) summary
    cd12639
    Location:327 → 405
    RRM3_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
    TIGR01661
    Location:43 → 412
    ELAV_HUD_SF; ELAV/HuD family splicing factor
    cd12635
    Location:40 → 120
    RRM2_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins

  2. NM_001202171.2 → NP_001189100.1  bruno 3, isoform M [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001189100.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    D1L6L6, M9MS39
    Conserved Domains (3) summary
    TIGR01628
    Location:31 → 165
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd12639
    Location:281 → 359
    RRM3_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
    cl17169
    Location:27 → 75
    RRM_SF; RNA recognition motif (RRM) superfamily

  3. NM_001202163.2 → NP_001189092.1  bruno 3, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001189092.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    D1L6L0, M9MRU5
    Conserved Domains (3) summary
    cd12639
    Location:319 → 397
    RRM3_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
    TIGR01661
    Location:43 → 404
    ELAV_HUD_SF; ELAV/HuD family splicing factor
    cd12635
    Location:40 → 120
    RRM2_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins

  4. NM_001202165.2 → NP_001189094.1  bruno 3, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001189094.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    D1L6L1, M9MRT4
    Conserved Domains (3) summary
    cd12639
    Location:301 → 379
    RRM3_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
    TIGR01661
    Location:40 → 386
    ELAV_HUD_SF; ELAV/HuD family splicing factor
    cd12635
    Location:40 → 120
    RRM2_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins

  5. NM_001202167.2 → NP_001189096.1  bruno 3, isoform I [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001189096.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    D1L6L1, D1L6L3, M9MRZ5
    Conserved Domains (3) summary
    cd12639
    Location:295 → 373
    RRM3_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
    TIGR01661
    Location:17 → 380
    ELAV_HUD_SF; ELAV/HuD family splicing factor
    cd12635
    Location:34 → 114
    RRM2_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins

  6. NM_001274879.1 → NP_001261808.1  bruno 3, isoform O [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261808.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    D1L6L0, M9PI52
    Conserved Domains (3) summary
    cd12635
    Location:35 → 115
    RRM2_CELF3_4_5_6; RNA recognition motif 2 in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
    cd12639
    Location:314 → 392
    RRM3_CELF3_4_5_6; RNA recognition motif 2 in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
    TIGR01661
    Location:38 → 399
    ELAV_HUD_SF; ELAV/HuD family splicing factor

  7. NM_001382117.1 → NP_001369051.1  bruno 3, isoform R [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A6M3Q7V1, D1L6L0
    Conserved Domains (4) summary
    cd12639
    Location:346 → 424
    RRM3_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
    TIGR01661
    Location:70 → 431
    ELAV_HUD_SF; ELAV/HuD family splicing factor
    cd12635
    Location:67 → 147
    RRM2_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
    cl17169
    Location:12 → 58
    RRM_SF; RNA recognition motif (RRM) superfamily

  8. NM_001274878.1 → NP_001261807.1  bruno 3, isoform N [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261807.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    D1L6L0, M9PI52
    Conserved Domains (3) summary
    cd12635
    Location:35 → 115
    RRM2_CELF3_4_5_6; RNA recognition motif 2 in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
    cd12639
    Location:314 → 392
    RRM3_CELF3_4_5_6; RNA recognition motif 2 in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
    TIGR01661
    Location:38 → 399
    ELAV_HUD_SF; ELAV/HuD family splicing factor

  9. NM_001202169.2 → NP_001189098.1  bruno 3, isoform K [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001189098.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    D1L6M0, M9MSL2
    Conserved Domains (3) summary
    cd12639
    Location:242 → 320
    RRM3_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
    TIGR01661
    Location:37 → 327
    ELAV_HUD_SF; ELAV/HuD family splicing factor
    cl17169
    Location:27 → 75
    RRM_SF; RNA recognition motif (RRM) superfamily

  10. NM_001202164.2 → NP_001189093.1  bruno 3, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001189093.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    D1L6L8, M9MSL1
    Conserved Domains (3) summary
    cd12639
    Location:248 → 326
    RRM3_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
    TIGR01661
    Location:140 → 333
    ELAV_HUD_SF; ELAV/HuD family splicing factor
    cl17169
    Location:27 → 75
    RRM_SF; RNA recognition motif (RRM) superfamily

  11. NM_079335.6 → NP_524059.4  bruno 3, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524059.4

    Status: REVIEWED

    UniProtKB/TrEMBL
    D1L6L6, Q9VU90
    Related
    FBpp0303379
    Conserved Domains (3) summary
    cd12639
    Location:274 → 352
    RRM3_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
    TIGR01661
    Location:140 → 359
    ELAV_HUD_SF; ELAV/HuD family splicing factor
    cl17169
    Location:27 → 75
    RRM_SF; RNA recognition motif (RRM) superfamily

  12. NM_001202170.2 → NP_001189099.1  bruno 3, isoform L [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001189099.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    D1L6L7, M9MRT9
    Conserved Domains (4) summary
    TIGR01628
    Location:31 → 173
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd12639
    Location:256 → 334
    RRM3_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
    TIGR01661
    Location:148 → 341
    ELAV_HUD_SF; ELAV/HuD family splicing factor
    cl17169
    Location:27 → 75
    RRM_SF; RNA recognition motif (RRM) superfamily

  13. NM_001202162.2 → NP_001189091.1  bruno 3, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001189091.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    D1L6L5, M9MRZ0
    Conserved Domains (3) summary
    cd12639
    Location:293 → 371
    RRM3_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
    TIGR01661
    Location:40 → 378
    ELAV_HUD_SF; ELAV/HuD family splicing factor
    cd12635
    Location:40 → 120
    RRM2_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins

  14. NM_001382115.1 → NP_001369049.1  bruno 3, isoform P [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    D1L6L0, M9MRU5
    Conserved Domains (3) summary
    cd12639
    Location:319 → 397
    RRM3_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
    TIGR01661
    Location:43 → 404
    ELAV_HUD_SF; ELAV/HuD family splicing factor
    cd12635
    Location:40 → 120
    RRM2_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins

  15. NM_001382116.1 → NP_001369050.1  bruno 3, isoform Q [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A6M3Q6L8
    Conserved Domains (3) summary
    cd12639
    Location:319 → 397
    RRM3_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
    TIGR01661
    Location:43 → 404
    ELAV_HUD_SF; ELAV/HuD family splicing factor
    cd12635
    Location:40 → 120
    RRM2_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins

  16. NM_001202168.2 → NP_001189097.1  bruno 3, isoform J [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001189097.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9MRV0

  17. NM_001202161.2 → NP_001189090.1  bruno 3, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001189090.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    D1L6L5, M9MS33
    Conserved Domains (3) summary
    cd12639
    Location:307 → 385
    RRM3_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
    TIGR01661
    Location:32 → 392
    ELAV_HUD_SF; ELAV/HuD family splicing factor
    cd12635
    Location:54 → 134
    RRM2_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins

  18. NM_168557.3 → NP_729923.1  bruno 3, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_729923.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    D1L6L0, Q95T02, Q9VU91
    Related
    FBpp0303375
    Conserved Domains (3) summary
    cd12639
    Location:333 → 411
    RRM3_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
    TIGR01661
    Location:57 → 418
    ELAV_HUD_SF; ELAV/HuD family splicing factor
    cd12635
    Location:54 → 134
    RRM2_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A6M3Q6L8 A0A6M3Q6L8
A0A6M3Q7V1 A0A6M3Q7V1
M9MRT4 M9MRT4
M9MRT9 M9MRT9
M9MRU5 M9MRU5
M9MRV0 M9MRV0
M9MRZ0 M9MRZ0
M9MRZ5 M9MRZ5
M9MS33 M9MS33
M9MS36 M9MS36
M9MS39 M9MS39
M9MSL1 M9MSL1
M9MSL2 M9MSL2
M9PI52 M9PI52
Q9VU90 Q9VU90
Q9VU91 Q9VU91

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