SMAD2 SMAD family member 2 [Gallus gallus (chicken)] - Gene

Summary

Official Symbol: SMAD2provided by CGNC
Official Full Name: SMAD family member 2provided by CGNC
Primary source: CGNC:49229
See related: Ensembl:ENSGALG00010010623
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as: MADH2; SMAD2Z
Orthologs: human mouse all
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Genomic context

Location:: chromosome: Z

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	Z	NC_052572.1 (1844055..1885830)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	Z	NC_059536.1 (1844055..1885830)

Chromosome Z - NC_052572.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Smad2 target proteins are activated solely by the Smad2-Smad2-Smad4 complex, whereas Smad3 targets are activated both by Smad2-Smad3-Smad4 and Smad3-Smad3-Smad4 trimers.
Title: Smad2 and Smad3 cooperate and antagonize simultaneously in vertebrate neurogenesis.
different levels of BMP signaling regulate Nodal expression by a balance between BMP-pSMAD1/4 signaling and NODAL-pSMAD2/4 signaling
Title: Multi-modal effects of BMP signaling on Nodal expression in the lateral plate mesoderm during left-right axis formation in the chick embryo.
MDV1-miR-M3 suppressed cisplatin-induced apoptosis by directly downregulating expression at the protein but not the mRNA level of Smad2, a critical component in the transforming growth factor beta signal pathway.
Title: Marek's disease virus type 1 microRNA miR-M3 suppresses cisplatin-induced apoptosis by targeting Smad2 of the transforming growth factor beta signal pathway.
concerted activation of both Smad2 and p38MAPK, appears to be a key aspect of regenerative corneal wound healing in the chick.
Title: Temporal and spatial distribution of TGF-beta isoforms and signaling intermediates in corneal regenerative wound repair.
TGF-beta3-induced Smad2 signaling, in conjunction with beta-catenin, is involved in the reorganization of the actin cytoskeleton into a cortical pattern with a concomitant rounding of cells
Title: Transforming growth factor-beta3-induced Smad signaling regulates actin reorganization during chondrogenesis of chick leg bud mesenchymal cells.
Smad2 is highly expressed in chicken granulosa cells (cGC) and localizes to the nucleus. Immunostaining of cGC with anti-Smad2 antibodies revealed efficient translocation of Smad2 into the nucleus.
Title: Activin a signaling induces Smad2, but not Smad3, requiring protein kinase a activity in granulosa cells from the avian ovary.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info	PubMed
enables I-SMAD binding	IEA Inferred from Electronic Annotation more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in BMP signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in SMAD protein signal transduction	IEA Inferred from Electronic Annotation more info	PubMed
involved_in anatomical structure morphogenesis	IEA Inferred from Electronic Annotation more info	PubMed
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info	PubMed
involved_in transforming growth factor beta receptor signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
part_of heteromeric SMAD protein complex	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: mothers against decapentaplegic homolog 2

Names: SMAD family member 2-Z; SMAD, mothers against DPP homolog 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001396710.1 → NP_001383639.1 mothers against decapentaplegic homolog 2 isoform 1

Status: VALIDATED

Source sequence(s)

JAENSK010000086

UniProtKB/TrEMBL

A0A182C5W6, A0A1D5PR93, A0A8V0Y5U0, E1C394, F1NFG1, Q8UWF3

Related

ENSGALP00010014319.1, ENSGALT00010025287.1

Conserved Domains (2) summary

cd10491
Location:8 → 172

MH1_SMAD_2_3; N-terminal Mad Homology 1 (MH1) domain in SMAD2 and SMAD3

cd10985
Location:266 → 456

MH2_SMAD_2_3; C-terminal Mad Homology 2 (MH2) domain in SMAD2 and SMAD3
NM_001396711.1 → NP_001383640.1 mothers against decapentaplegic homolog 2 isoform 2

Status: VALIDATED

Source sequence(s)

JAENSK010000086

UniProtKB/TrEMBL

A0A3Q3AN84, A0A8V0Y5U0

Conserved Domains (2) summary

cd10491
Location:8 → 142

MH1_SMAD_2_3; N-terminal Mad Homology 1 (MH1) domain in SMAD2 and SMAD3

cd10985
Location:236 → 426

MH2_SMAD_2_3; C-terminal Mad Homology 2 (MH2) domain in SMAD2 and SMAD3
NM_001396712.1 → NP_001383641.1 mothers against decapentaplegic homolog 2 isoform 1

Status: VALIDATED

Source sequence(s)

JAENSK010000086

UniProtKB/TrEMBL

A0A182C5W6, A0A1D5PR93, A0A8V0Y5U0, E1C394, F1NFG1, Q8UWF3

Conserved Domains (2) summary

cd10491
Location:8 → 172

MH1_SMAD_2_3; N-terminal Mad Homology 1 (MH1) domain in SMAD2 and SMAD3

cd10985
Location:266 → 456

MH2_SMAD_2_3; C-terminal Mad Homology 2 (MH2) domain in SMAD2 and SMAD3
NM_001396713.1 → NP_001383642.1 mothers against decapentaplegic homolog 2 isoform 2

Status: VALIDATED

Source sequence(s)

JAENSK010000086

UniProtKB/TrEMBL

A0A3Q3AN84, A0A8V0Y5U0

Related

ENSGALP00010014330.1, ENSGALT00010025309.1

Conserved Domains (2) summary

cd10491
Location:8 → 142

MH1_SMAD_2_3; N-terminal Mad Homology 1 (MH1) domain in SMAD2 and SMAD3

cd10985
Location:236 → 426

MH2_SMAD_2_3; C-terminal Mad Homology 2 (MH2) domain in SMAD2 and SMAD3
NM_204561.2 → NP_989892.1 mothers against decapentaplegic homolog 2 isoform 1

See identical proteins and their annotated locations for NP_989892.1

Status: VALIDATED

Source sequence(s)

JAENSK010000086

UniProtKB/TrEMBL

A0A182C5W6, A0A1D5PR93, A0A8V0Y5U0, E1C394, F1NFG1, Q8UWF3

Conserved Domains (2) summary

cd10491
Location:8 → 172

MH1_SMAD_2_3; N-terminal Mad Homology 1 (MH1) domain in SMAD2 and SMAD3

cd10985
Location:266 → 456

MH2_SMAD_2_3; C-terminal Mad Homology 2 (MH2) domain in SMAD2 and SMAD3

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

NC_052572.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Range

1844055..1885830

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_046905190.1 → XP_046761146.1 mothers against decapentaplegic homolog 2 isoform X1

UniProtKB/TrEMBL

A0A182C5W6, A0A1D5PR93, E1C394, F1NFG1, Q8UWF3
XM_046905191.1 → XP_046761147.1 mothers against decapentaplegic homolog 2 isoform X2

Conserved Domains (2) summary

cd10985
Location:170 → 360

MH2_SMAD_2_3; C-terminal Mad Homology 2 (MH2) domain in SMAD2 and SMAD3

cl00055
Location:13 → 76

MH1; N-terminal Mad Homology 1 (MH1) domain

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

NC_059536.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Range

1844055..1885830

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_046934680.1 → XP_046790636.1 mothers against decapentaplegic homolog 2 isoform X1

UniProtKB/TrEMBL

A0A182C5W6, A0A1D5PR93, E1C394, F1NFG1, Q8UWF3
XM_046934681.1 → XP_046790637.1 mothers against decapentaplegic homolog 2 isoform X2

Conserved Domains (2) summary

cd10985
Location:170 → 360

MH2_SMAD_2_3; C-terminal Mad Homology 2 (MH2) domain in SMAD2 and SMAD3

cl00055
Location:13 → 76

MH1; N-terminal Mad Homology 1 (MH1) domain