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WNT6 Wnt family member 6 [ Gallus gallus (chicken) ]

Gene ID: 395235, updated on 3-Apr-2024

Summary

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Symbol
WNT6provided by CGNC
Full Name
Wnt family member 6provided by CGNC
Primary source
CGNC:8636
See related
Ensembl:ENSGALG00010021142
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 7
Exon count:
4
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 7 NC_052538.1 (22026370..22035132, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 7 NC_052579.1 (21946158..21954922, complement)

Chromosome 7 - NC_052538.1Genomic Context describing neighboring genes Neighboring gene cyclin dependent kinase 5 regulatory subunit 2 Neighboring gene transfer RNA valine (anticodon GAC) Neighboring gene Wnt family member 10A Neighboring gene cytochrome P450 family 27 subfamily A member 1 Neighboring gene protein kinase AMP-activated non-catalytic subunit gamma 3 Neighboring gene tubulin tyrosine ligase like 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Ectodermal Wnt6 is an early negative regulator of limb chondrogenesis in the chicken embryo. Geetha-Loganathan P, et al. BMC Dev Biol, 2010 Mar 25. PMID 20334703, Free PMC Article
  2. Wnt6 controls amniote neural crest induction through the non-canonical signaling pathway. Schmidt C, et al. Dev Dyn, 2007 Sep. PMID 17685490
  3. Role of Wnt-6 in limb myogenesis. Geetha-Loganathan P, et al. Anat Embryol (Berl), 2006 Jun. PMID 16369823
  4. Ectodermal Wnt-6 promotes Myf5-dependent avian limb myogenesis. Geetha-Loganathan P, et al. Dev Biol, 2005 Dec 1. PMID 16271265
  5. Wnt6 marks sites of epithelial transformations in the chick embryo. Schubert FR, et al. Mech Dev, 2002 Jun. PMID 12175501

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Study identifies Wnt6 as a candidate mediator of ectodermal chondrogenic inhibition in vivo.
    Title: Ectodermal Wnt6 is an early negative regulator of limb chondrogenesis in the chicken embryo.
  2. Wnt6 has a role in controlling amniote neural crest induction through the non-canonical signaling pathway
    Title: Wnt6 controls amniote neural crest induction through the non-canonical signaling pathway.
  3. Wnt11 and Wnt6 act as factors maintaining the epithelial nature of the dorsomedial and ventrolateral lips of the dermomyotome.
    Title: Regulation of ectodermal Wnt6 expression by the neural tube is transduced by dermomyotomal Wnt11: a mechanism of dermomyotomal lip sustainment.
  4. plays a unique role in promoting limb myogenesis via Pax3, Paraxis, and myogenic regulatory factor 5 in chick embryo
    Title: Ectodermal Wnt-6 promotes Myf5-dependent avian limb myogenesis.
  5. In a study of quail somites transplanted to chick limb buds Wnt-6 is found to be an ectodermal signal that induces somite-derived progenitor cells to form muscle cells during limb development.
    Title: Role of Wnt-6 in limb myogenesis.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables cytokine activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables frizzled binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in canonical Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell fate commitment IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in multicellular organism development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in neuron differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
protein Wnt-6
Names
wingless-related MMTV integration site 6 homolog
wingless-type MMTV integration site family member 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001007594.3 → NP_001007595.1  protein Wnt-6

    See identical proteins and their annotated locations for NP_001007595.1

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000236
    UniProtKB/TrEMBL
    A0A8V0ZHX2
    Conserved Domains (1) summary
    cd19338
    Location:1 → 319
    Wnt_Wnt6; Wnt domain found in protein Wnt-6 and similar proteins

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052538.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    22026370..22035132 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015289781.4 → XP_015145267.1  protein Wnt-6 isoform X2

    UniProtKB/TrEMBL
    A0A8V0ZHX2
    Conserved Domains (1) summary
    cd19338
    Location:1 → 319
    Wnt_Wnt6; Wnt domain found in protein Wnt-6 and similar proteins

  2. XM_015289779.4 → XP_015145265.1  protein Wnt-6 isoform X1

    UniProtKB/TrEMBL
    A0A8V0ZNV6, F1NZU6, Q3C2H6
    Related
    ENSGALP00010030389.1, ENSGALT00010051199.1
    Conserved Domains (1) summary
    cd19338
    Location:34 → 352
    Wnt_Wnt6; Wnt domain found in protein Wnt-6 and similar proteins

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052579.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    21946158..21954922 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046920934.1 → XP_046776890.1  protein Wnt-6 isoform X4

  2. XM_046920933.1 → XP_046776889.1  protein Wnt-6 isoform X3

  3. XM_046920935.1 → XP_046776891.1  protein Wnt-6 isoform X1

    UniProtKB/TrEMBL
    F1NZU6, Q3C2H6
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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