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HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase [ Gallus gallus (chicken) ]

Gene ID: 395145, updated on 3-Apr-2024

Summary

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Symbol
HMGCRprovided by CGNC
Full Name
3-hydroxy-3-methylglutaryl-CoA reductaseprovided by CGNC
Primary source
CGNC:11100
See related
Ensembl:ENSGALG00010011029
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
HMGR
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: Z
Exon count:
22
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) Z NC_052572.1 (24562779..24580460, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) Z NC_059536.1 (24562779..24580460, complement)

Chromosome Z - NC_052572.1Genomic Context describing neighboring genes Neighboring gene ceramide transporter 1 Neighboring gene mediator complex subunit 18 Neighboring gene ankyrin repeat domain 31 Neighboring gene uncharacterized LOC121108366 Neighboring gene glucosaminyl (N-acetyl) transferase 4, core 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Three novel single nucleotide polymorphisms of the 3-hydroxy-3-methylglutaryl coenzyme A reductase gene associated with egg-production in chicken. Han C, et al. Folia Biol (Krakow), 2014. PMID 25403074
  2. Telomeric DNA quantity, DNA damage, and heat shock protein gene expression as physiological stress markers in chickens. Sohn SH, et al. Poult Sci, 2012 Apr. PMID 22399721
  3. The effect of a mutation in the 3-UTR region of the HMGCR gene on cholesterol in Beijing-you chickens. Cui HX, et al. Anim Biotechnol, 2010 Oct. PMID 20967643
  4. Albusin B modulates lipid metabolism and increases antioxidant defense in broiler chickens by a proteomic approach. Wang HT, et al. J Sci Food Agric, 2013 Jan. PMID 22729694
  5. Changes in mRNA expression of 3-hydroxy-3-methylglutaryl coenzyme A reductase and cholesterol 7 alpha-hydroxylase in chickens. Sato K, et al. Biochim Biophys Acta, 2003 Nov 30. PMID 14654239

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Dietary CLA supplementation decreased the accumulation of lipids including abdominal fat and cholesterol in the liver and egg of laying hens, probably by upregulating hepatic LDLR expression and downregulating hepatic HMGR and CYP7A1 expression.
    Title: Conjugated linoleic acid regulates lipid metabolism through the expression of selected hepatic genes in laying hens.
  2. It was concluded that specific variants of the HMGCR gene are associated with chicken egg production, and haplotypes with higher and lower plasma VLDL concentrations showed lower egg production than other haplotypes.
    Title: Three novel single nucleotide polymorphisms of the 3-hydroxy-3-methylglutaryl coenzyme A reductase gene associated with egg-production in chicken.
  3. HMGCR polymorphisms in chickens have significant effects on growth, carcass, meat quality, and lipid concentration.
    Title: Two novel SNPs of the 3-hydroxy-3-methylglutaryl coenzyme A reductase gene associated with growth and meat quality traits in the chicken.
  4. Data suggest that liver HMGCR can be induced by dietary factors (here, supplementation with bacteriocin albusin B from Ruminococcus albus).
    Title: Albusin B modulates lipid metabolism and increases antioxidant defense in broiler chickens by a proteomic approach.
  5. Stress conditions had a significant effect on the expression of HMGCR and HSP90alpha in lymphocytes. Telomere length, especially telomere-shortening rates, and expression levels of these two genes can be used as sensitive physiological stress markers.
    Title: Telomeric DNA quantity, DNA damage, and heat shock protein gene expression as physiological stress markers in chickens.
  6. The 3-hydroxyl-3-methylglutaryl Coenzyme A reductase (HMGCR) gene was examined for polymorphisms in Beijing-you chickens.
    Title: The effect of a mutation in the 3-UTR region of the HMGCR gene on cholesterol in Beijing-you chickens.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables NADP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables hydroxymethylglutaryl-CoA reductase (NADPH) activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in coenzyme A metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in isoprenoid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in sterol biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in peroxisomal membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
3-hydroxy-3-methylglutaryl-Coenzyme A reductase
NP_989816.3
XP_015132713.2
XP_040511269.2
XP_046761143.1
XP_046790625.1
XP_046790626.1
XP_046790627.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_204485.3 → NP_989816.3  3-hydroxy-3-methylglutaryl-Coenzyme A reductase

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000089
    UniProtKB/TrEMBL
    A0A8V0Y361, A0A8V0Y7V5
    Related
    ENSGALP00010015044.1, ENSGALT00010026432.1
    Conserved Domains (1) summary
    TIGR00920
    Location:1 → 882
    2A060605; 3-hydroxy-3-methylglutaryl-coenzyme A reductase

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052572.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    24562779..24580460 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_040655335.2 → XP_040511269.2  3-hydroxy-3-methylglutaryl-Coenzyme A reductase isoform X1

    UniProtKB/TrEMBL
    A0A8V0Y361
    Related
    ENSGALP00010015034.1, ENSGALT00010026421.1

  2. XM_015277227.4 → XP_015132713.2  3-hydroxy-3-methylglutaryl-Coenzyme A reductase isoform X1

    UniProtKB/TrEMBL
    A0A8V0Y361, A0A8V0Y7V5
    Conserved Domains (1) summary
    TIGR00920
    Location:1 → 882
    2A060605; 3-hydroxy-3-methylglutaryl-coenzyme A reductase

  3. XM_046905187.1 → XP_046761143.1  3-hydroxy-3-methylglutaryl-Coenzyme A reductase isoform X1

    UniProtKB/TrEMBL
    A0A8V0Y361

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_059536.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    24562779..24580460 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046934669.1 → XP_046790625.1  3-hydroxy-3-methylglutaryl-Coenzyme A reductase isoform X1

    UniProtKB/TrEMBL
    A0A8V0Y361

  2. XM_046934670.1 → XP_046790626.1  3-hydroxy-3-methylglutaryl-Coenzyme A reductase isoform X1

    UniProtKB/TrEMBL
    A0A8V0Y361

  3. XM_046934671.1 → XP_046790627.1  3-hydroxy-3-methylglutaryl-Coenzyme A reductase isoform X1

    UniProtKB/TrEMBL
    A0A8V0Y361
Nucleotide Protein Strain
Heading Accession and Version

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