LDLR low density lipoprotein receptor [Gallus gallus (chicken)] - Gene

Summary

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Gene symbol: LDLR
Gene description: low density lipoprotein receptor
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Annotation information: not in current annotation release
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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Dietary CLA supplementation decreased the accumulation of lipids including abdominal fat and cholesterol in the liver and egg of laying hens, probably by upregulating hepatic LDLR expression and downregulating hepatic HMGR and CYP7A1 expression.
Title: Conjugated linoleic acid regulates lipid metabolism through the expression of selected hepatic genes in laying hens.
LDL receptor and LDL receptor related protein 1 mRNA tended to increase with follicular development.
Title: Modulation of sterol regulatory element binding protein-2 in response to rapid follicle development in chickens.

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General protein information

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Preferred Names: low density lipoprotein receptor

Names: LDL receptor; low density lipoprotein receptor (familial hypercholesterolemia)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_204452.1 → NP_989783.1 low density lipoprotein receptor precursor

See identical proteins and their annotated locations for NP_989783.1

Status: PROVISIONAL

Source sequence(s)

AJ515243

UniProtKB/TrEMBL

Q7T2X3

Conserved Domains (4) summary

smart00135
Location:574 → 616

LY; Low-density lipoprotein-receptor YWTD domain

cd00112
Location:210 → 244

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

pfam14670
Location:332 → 367

FXa_inhibition; Coagulation Factor Xa inhibitory site

cl00057
Location:364 → 406

vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...