IGF2 insulin like growth factor 2 [Gallus gallus (chicken)] - Gene

Summary

Symbol: IGF2provided by CGNC
Full Name: insulin like growth factor 2provided by CGNC
Primary source: CGNC:4942
See related: Ensembl:ENSGALG00010024580
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as: IGF-II
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 5

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	5	NC_052536.1 (13375612..13394087)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	5	NC_052577.1 (13344055..13362540)

Chromosome 5 - NC_052536.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

we found that MYOD transcription factor can upregulate miR-223 expression by binding to an E-box region of the gga-miR-223 gene promoter during avian myoblast differentiation. IGF2 and ZEB1 are two target genes of miR-223
Title: miRNA-223 upregulated by MYOD inhibits myoblast proliferation by repressing IGF2 and facilitates myoblast differentiation by inhibiting ZEB1.
IGF1 and IGF2 might separately be more important for muscle and liver growth in chick embryonic development. Variation of IGFs expression during the incubation might be concerned with the methylation of gene promoter.
Title: Developmental changes of Insulin-like growth factors in the liver and muscle of chick embryos.
These findings implied that polymorphisms within IGF1 and IGF2 genes could be in linkage disequilibrium with the actual causative mutations that affect growth and carcass traits.
Title: Evaluation of the IGFs (IGF1 and IGF2) genes as candidates for growth, body measurement, carcass, and reproduction traits in Beijing You and Silkie chickens.
Blood levels of IGF-II may be a more important functionary for chick embryonic development than IGF-I.
Title: Developmental changes of plasma insulin, glucagon, insulin-like growth factors, thyroid hormones, and glucose concentrations in chick embryos and hatched chicks.
IGF2 is a candidate gene influencing growth and carcass traits, and has biallelic expression.
Title: Insulin-like growth factor 2 as a candidate gene influencing growth and carcass traits and its bialleleic expression in chicken.
These findings provide the first evidence for a potential role of the insulin-like growth factor II-vitronectin complex during the endothelial-to-mesenchymal transition process.
Title: Potential role for insulin-like growth factor II and vitronectin in the endothelial-mesenchymal transition process.
These results suggest that the mechanism of action whereby IGFBP2 excess impairs long bone development is to inhibit IGF-I and IGF-II-mediated proliferation and matrix synthesis.
Title: Role of IGFBP2, IGF-I and IGF-II in regulating long bone growth.

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General gene information

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Markers

MPR1sts1 (e-PCR), detects polymorphism
- UniSTS:280212

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables growth factor activity	IEA Inferred from Electronic Annotation more info	PubMed
enables hormone activity	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: insulin-like growth factor II

Names: insulin-like growth factor 2 (somatomedin A); insulin-like growth factor 2 (somatomedin A)prepro-IGF-IIprepro-insulin-like growth factor-II; prepro-IGF-II; prepro-insulin-like growth factor-II

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001030342.5 → NP_001025513.1 insulin-like growth factor II precursor

See identical proteins and their annotated locations for NP_001025513.1

Status: VALIDATED

Source sequence(s)

JAENSK010000214

UniProtKB/Swiss-Prot

P33717, P79890, Q7ZZT6

UniProtKB/TrEMBL

A0A8V0ZYE3

Related

ENSGALP00010036718.1, ENSGALT00010059958.1

Conserved Domains (2) summary

cd04368
Location:28 → 91

IlGF; IlGF, insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On ...

pfam08365
Location:117 → 173

IGF2_C; Insulin-like growth factor II E-peptide