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Srrm1 Serine-arginine repetitive matrix 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 39483, updated on 10-May-2024

Summary

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Official Symbol
Srrm1provided by FlyBase
Official Full Name
Serine-arginine repetitive matrix 1provided by FlyBase
Primary source
FLYBASE:FBgn0036340
Locus tag
Dmel_CG11274
See related
AllianceGenome:FB:FBgn0036340
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG11274; Dmel\CG11274; SRm160; SRM160
Summary
Involved in several processes, including genitalia development; regulation of alternative mRNA splicing, via spliceosome; and somatic sex determination. Located in nucleus. Part of catalytic step 2 spliceosome and precatalytic spliceosome. Is expressed in several structures, including central nervous system; dorsal closure embryo; embryonic/larval gut; and imaginal disc. Orthologous to human SRRM1 (serine and arginine repetitive matrix 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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Location:
69F6-69F6; 3-39 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (13036821..13040976)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (13029921..13034076)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45172 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45157 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Ribosomal protein S4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Rhythmic Behavior Is Controlled by the SRm160 Splicing Factor in Drosophila melanogaster. Beckwith EJ, et al. Genetics, 2017 Oct. PMID 28801530, Free PMC Article
  2. Exonic splicing enhancers: mechanism of action, diversity and role in human genetic diseases. Blencowe BJ. Trends Biochem Sci, 2000 Mar. PMID 10694877
  3. Multifunctional RNA processing protein SRm160 induces apoptosis and regulates eye and genital development in Drosophila. Fan YJ, et al. Genetics, 2014 Aug. PMID 24907259, Free PMC Article
  4. REF1/Aly and the additional exon junction complex proteins are dispensable for nuclear mRNA export. Gatfield D, et al. J Cell Biol, 2002 Nov 25. PMID 12438415, Free PMC Article
  5. The exon junction complex: a splicing factor for long intron containing transcripts? Ashton-Beaucage D, et al. Fly (Austin), 2011 Jul-Sep. PMID 21478676

See all (51) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Analyses of fly mutants demonstrated that the SRm160 level affects AS(alternative splicing) isoforms of transformer protein, thus determining Drosophila sex determination and development.
    Title: HITS-CLIP reveals sex-differential RNA binding and alterative splicing regulation of SRm160 in Drosophila.
  2. SRm160 affects gene expression in pacemaker neurons to ensure proper oscillations of the molecular clock. SRm160 positively regulates per levels in a splicing-dependent manner.
    Title: Rhythmic Behavior Is Controlled by the SRm160 Splicing Factor in Drosophila melanogaster.
  3. Our results demonstrate that correct dosage of SRm160 function is vital to the survival of the animal, since its overexpression or depletion via mutation or RNA interference is lethal.
    Title: Multifunctional RNA processing protein SRm160 induces apoptosis and regulates eye and genital development in Drosophila.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in compound eye development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in genitalia development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA splicing, via spliceosome IC
Inferred by Curator
more info
 PubMed 
involved_in positive regulation of programmed cell death IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of alternative mRNA splicing, via spliceosome IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of circadian rhythm IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in somatic sex determination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of catalytic step 2 spliceosome HDA PubMed 
part_of exon-exon junction complex TAS
Traceable Author Statement
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
part_of precatalytic spliceosome HDA PubMed 
part_of spliceosomal complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Serine-arginine repetitive matrix 1
Names
CG11274-PA
SRm160
Srrm1-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    13036821..13040976
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_140370.3 → NP_648627.1  Serine-arginine repetitive matrix 1 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_648627.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q6AWQ1, Q9VU43
    Related
    FBpp0075617
    Conserved Domains (1) summary
    pfam01480
    Location:43 → 113
    PWI; PWI domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6AWQ1 Q6AWQ1
Q9VU43 Q9VU43

Gene LinkOut

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