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pafah1b1b platelet-activating factor acetylhydrolase 1b, regulatory subunit 1b [ Danio rerio (zebrafish) ]

Gene ID: 394247, updated on 11-Apr-2024

Summary

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Official Symbol
pafah1b1bprovided by ZNC
Official Full Name
platelet-activating factor acetylhydrolase 1b, regulatory subunit 1bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040116-3
See related
Ensembl:ENSDARG00000026595 AllianceGenome:ZFIN:ZDB-GENE-040116-3
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
Lis1a
Summary
Predicted to enable dynein complex binding activity; microtubule plus-end binding activity; and protein heterodimerization activity. Acts upstream of or within several processes, including apical protein localization; brain morphogenesis; and photoreceptor cell maintenance. Located in cytoplasm. Is expressed in several structures, including gill; heart; liver; nervous system; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in lissencephaly and lissencephaly 1. Orthologous to human PAFAH1B1 (platelet activating factor acetylhydrolase 1b regulatory subunit 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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Location:
chromosome: 21
Exon count:
12
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 21 NC_007132.7 (39424058..39454196)
105 previous assembly GRCz10 (GCF_000002035.5) 21 NC_007132.6 (39379000..39407738)

Chromosome 21 - NC_007132.7Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 92Bb Neighboring gene clustered mitochondria protein homolog Neighboring gene MAX network transcriptional repressor b Neighboring gene septin 4a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Characterization of the overlapping expression patterns of the zebrafish LIS1 orthologs. Drerup CM, et al. Gene Expr Patterns, 2010 Jan. PMID 19822223
  2. Expression and function on embryonic development of lissencephaly-1 genes in zebrafish. Sun C, et al. Acta Biochim Biophys Sin (Shanghai), 2009 Aug. PMID 19657569
  3. Analysis of nicastrin gene phylogeny and expression in zebrafish. Lim A, et al. Dev Genes Evol, 2015 Jun. PMID 25940938
  4. Mechanism of positioning the cell nucleus in vertebrate photoreceptors. Tsujikawa M, et al. Proc Natl Acad Sci U S A, 2007 Sep 11. PMID 17785424, Free PMC Article
  5. Phenotypic analysis of catastrophic childhood epilepsy genes. Griffin A, et al. Commun Biol, 2021 Jun 3. PMID 34083748, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables dynein complex binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables dynein complex binding IEA
Inferred from Electronic Annotation
more info
  
enables microtubule plus-end binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein heterodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within apical protein localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in brain morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within brain morphogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within brain morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in establishment of mitotic spindle orientation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in establishment of mitotic spindle orientation IEA
Inferred from Electronic Annotation
more info
  
involved_in germ cell development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in microtubule organizing center organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in microtubule sliding IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within nervous system development IEA
Inferred from Electronic Annotation
more info
  
involved_in nuclear migration IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within nuclear migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within photoreceptor cell maintenance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in reelin-mediated signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in retrograde axonal transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in vesicle transport along microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of 1-alkyl-2-acetylglycerophosphocholine esterase complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in centrosome IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasmic microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
is_active_in kinetochore IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
part_of microtubule associated complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of microtubule associated complex IEA
Inferred from Electronic Annotation
more info
  
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in neuronal cell body IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nuclear envelope IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
lissencephaly-1 homolog B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_201346.1 → NP_958503.1  lissencephaly-1 homolog B

    See identical proteins and their annotated locations for NP_958503.1

    Status: PROVISIONAL

    Source sequence(s)
    BC044530
    UniProtKB/Swiss-Prot
    Q07DR2, Q803D2
    Related
    ENSDARP00000039257.5, ENSDART00000031470.6
    Conserved Domains (4) summary
    COG2319
    Location:100 → 410
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:104 → 408
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam08513
    Location:9 → 35
    LisH; LisH
    sd00039
    Location:111 → 148
    7WD40; WD40 repeat [structural motif]

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007132.7 Reference GRCz11 Primary Assembly

    Range
    39424058..39454196
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021468786.1 → XP_021324461.1  lissencephaly-1 homolog B isoform X1

    UniProtKB/TrEMBL
    A0A8M9PQB6
    Conserved Domains (3) summary
    cd00200
    Location:104 → 408
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:111 → 148
    7WD40; WD40 repeat [structural motif]
    pfam08513
    Location:9 → 35
    LisH; LisH
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q803D2.3 GenPept UniProtKB/Swiss-Prot:Q803D2

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