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ahcyl2b adenosylhomocysteinase like 2b [ Danio rerio (zebrafish) ]

Gene ID: 394240, updated on 27-Mar-2024

Summary

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Official Symbol
ahcyl2bprovided by ZNC
Official Full Name
adenosylhomocysteinase like 2bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040115-5
See related
Ensembl:ENSDARG00000039343 AllianceGenome:ZFIN:ZDB-GENE-040115-5
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
ahcyl2
Summary
Predicted to enable adenosylhomocysteinase activity. Predicted to be involved in S-adenosylmethionine cycle. Predicted to act upstream of or within one-carbon metabolic process. Predicted to be active in cytosol. Is expressed in several structures, including notochord; otic placode; otic vesicle; pronephric duct; and segmental plate. Orthologous to human AHCYL2 (adenosylhomocysteinase like 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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Location:
chromosome: 4
Exon count:
17
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 4 NC_007115.7 (5026012..5092191, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 4 NC_007115.6 (5016537..5083621, complement)

Chromosome 4 - NC_007115.7Genomic Context describing neighboring genes Neighboring gene si:dkey-14d8.24 Neighboring gene uncharacterized LOC101884589 Neighboring gene striatin interacting protein 2 Neighboring gene transmembrane protein 209 Neighboring gene cyclin D2, b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Suppression and overexpression of adenosylhomocysteine hydrolase-like protein 1 (AHCYL1) influences zebrafish embryo development: a possible role for AHCYL1 in inositol phospholipid signaling. Cooper BJ, et al. J Biol Chem, 2006 Aug 11. PMID 16754674
  2. Comprehensive profiling of zebrafish hepatic proximal promoter CpG island methylation and its modification during chemical carcinogenesis. Mirbahai L, et al. BMC Genomics, 2011 Jan 4. PMID 21205313, Free PMC Article
  3. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
  4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
NOT enables adenosylhomocysteinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables adenosylhomocysteinase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in S-adenosylmethionine cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within one-carbon metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
adenosylhomocysteinase like 2b
Names
S-adenosylhomocysteine hydrolase-like 2
adenosylhomocysteinase-like 2
NP_958497.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_201340.1 → NP_958497.1  adenosylhomocysteinase like 2b

    See identical proteins and their annotated locations for NP_958497.1

    Status: PROVISIONAL

    Source sequence(s)
    BC059517
    UniProtKB/TrEMBL
    A0A8M1PCF8, F1QFK1, Q6PC06
    Related
    ENSDARP00000111142.2, ENSDART00000130453.4
    Conserved Domains (2) summary
    PRK05476
    Location:165 → 585
    PRK05476; S-adenosyl-L-homocysteine hydrolase; Provisional
    pfam05221
    Location:165 → 590
    AdoHcyase; S-adenosyl-L-homocysteine hydrolase

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007115.7 Reference GRCz11 Primary Assembly

    Range
    5026012..5092191 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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