pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: pik3cdprovided by ZNC
Official Full Name: phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit deltaprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-1128
See related: Ensembl:ENSDARG00000003250 AllianceGenome:ZFIN:ZDB-GENE-040426-1128
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:63473
Summary: Predicted to enable 1-phosphatidylinositol-3-kinase activity and 1-phosphatidylinositol-4-phosphate 3-kinase activity. Acts upstream of or within regulation of collateral sprouting in absence of injury. Predicted to be part of phosphatidylinositol 3-kinase complex. Predicted to be active in cytoplasm and plasma membrane. Is expressed in central nervous system; cranial ganglion; and ventral wall of dorsal aorta. Human ortholog(s) of this gene implicated in colorectal cancer; endometrial cancer; and immunodeficiency 14. Orthologous to human PIK3CD (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 23

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	23	NC_007134.7 (29756600..29812667, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	23	NC_007134.6 (29830059..29886126, complement)

Chromosome 23 - NC_007134.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Activated PI3K delta syndrome 1 mutations cause neutrophilia in zebrafish larvae.
Title: Activated PI3K delta syndrome 1 mutations cause neutrophilia in zebrafish larvae.
PI3 kinase has a role in retinal angiogenesis
Title: Selective inhibition of retinal angiogenesis by targeting PI3 kinase.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables 1-phosphatidylinositol-3-kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 1-phosphatidylinositol-3-kinase activity	IEA Inferred from Electronic Annotation more info
enables 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity	IEA Inferred from Electronic Annotation more info
enables 1-phosphatidylinositol-4-phosphate 3-kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within phosphatidylinositol 3-kinase/protein kinase B signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within phosphatidylinositol phosphate biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in phosphatidylinositol-3-phosphate biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphatidylinositol-mediated signaling	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of collateral sprouting in absence of injury	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of collateral sprouting in absence of injury	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
part_of phosphatidylinositol 3-kinase complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform

Names: phosphoinositide-3-kinase, catalytic, delta polypeptide

NP_957493.1

EC 2.7.1.153

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_201199.1 → NP_957493.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform

See identical proteins and their annotated locations for NP_957493.1

Status: PROVISIONAL

Source sequence(s)

BC054896

UniProtKB/TrEMBL

Q7SYE7

Related

ENSDARP00000017757.7, ENSDART00000006120.10

Conserved Domains (5) summary

cd08693
Location:315 → 481

C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)

cd00872
Location:505 → 676

PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...

cd05174
Location:676 → 1038

PI3Kc_IA_delta; Catalytic domain of Class IA Phosphoinositide 3-kinase delta

pfam02192
Location:32 → 107

PI3K_p85B; PI3-kinase family, p85-binding domain

cl02484
Location:188 → 280

PI3K_rbd; PI3-kinase family, ras-binding domain