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tra2b transformer 2 beta homolog [ Danio rerio (zebrafish) ]

Gene ID: 394172, updated on 27-Mar-2024

Summary

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Official Symbol
tra2bprovided by ZNC
Official Full Name
transformer 2 beta homologprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-1094
See related
Ensembl:ENSDARG00000002168 AllianceGenome:ZFIN:ZDB-GENE-040426-1094
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
sfrs10; zgc:56612
Summary
Predicted to enable RNA binding activity. Predicted to be involved in positive regulation of mRNA splicing, via spliceosome. Predicted to be part of spliceosomal complex. Is expressed in brain. Orthologous to human TRA2B (transformer 2 beta homolog). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 9
Exon count:
8
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 9 NC_007120.7 (12579077..12594777, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 9 NC_007120.6 (12607874..12623574, complement)

Chromosome 9 - NC_007120.7Genomic Context describing neighboring genes Neighboring gene transmembrane protein 41aa Neighboring gene insulin-like growth factor 2 mRNA binding protein 2a Neighboring gene uncharacterized LOC110440041 Neighboring gene thrombospondin-type laminin G domain and EAR repeats b Neighboring gene small ubiquitin like modifier 3b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Hypoxia alters expression of zebrafish microtubule-associated protein tau (mapta, maptb) gene transcripts. Moussavi Nik SH, et al. BMC Res Notes, 2014 Oct 31. PMID 25359609, Free PMC Article
  2. Functional characterization of a FUS mutant zebrafish line as a novel genetic model for ALS. Bourefis AR, et al. Neurobiol Dis, 2020 Aug. PMID 32380281
  3. Ribosomal Proteins Rpl22 and Rpl22l1 Control Morphogenesis by Regulating Pre-mRNA Splicing. Zhang Y, et al. Cell Rep, 2017 Jan 10. PMID 28076796, Free PMC Article
  4. An evolutionary approach to recover genes predominantly expressed in the testes of the zebrafish, chicken and mouse. Fouchécourt S, et al. BMC Evol Biol, 2019 Jul 3. PMID 31269894, Free PMC Article
  5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC56612

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in positive regulation of mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of spliceosomal complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
transformer-2 protein homolog beta
Names
splicing factor, arginine/serine-rich, 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_201197.1 → NP_957491.1  transformer-2 protein homolog beta

    See identical proteins and their annotated locations for NP_957491.1

    Status: PROVISIONAL

    Source sequence(s)
    BC049051
    UniProtKB/TrEMBL
    Q7ZUG9
    Related
    ENSDARP00000016139.6, ENSDART00000021266.7
    Conserved Domains (2) summary
    COG0724
    Location:118 → 199
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12641
    Location:114 → 202
    RRM_TRA2B; RNA recognition motif in Transformer-2 protein homolog beta (TRA-2 beta) and similar proteins

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007120.7 Reference GRCz11 Primary Assembly

    Range
    12579077..12594777 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005167473.2 → XP_005167530.1  transformer-2 protein homolog beta isoform X1

    See identical proteins and their annotated locations for XP_005167530.1

    UniProtKB/TrEMBL
    A0A8M2BEY8
    Conserved Domains (2) summary
    COG0724
    Location:13 → 94
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12641
    Location:9 → 97
    RRM_TRA2B; RNA recognition motif in Transformer-2 protein homolog beta (TRA-2 beta) and similar proteins

  2. XM_005167474.4 → XP_005167531.1  transformer-2 protein homolog beta isoform X1

    See identical proteins and their annotated locations for XP_005167531.1

    UniProtKB/TrEMBL
    A0A8M2BEY8
    Conserved Domains (2) summary
    COG0724
    Location:13 → 94
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12641
    Location:9 → 97
    RRM_TRA2B; RNA recognition motif in Transformer-2 protein homolog beta (TRA-2 beta) and similar proteins
Nucleotide Protein Strain
Heading Accession and Version

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