cyp7a1 cytochrome P450, family 7, subfamily A, polypeptide 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: cyp7a1provided by ZNC
Official Full Name: cytochrome P450, family 7, subfamily A, polypeptide 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-1296
See related: Ensembl:ENSDARG00000069018 AllianceGenome:ZFIN:ZDB-GENE-040426-1296
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cyp7a1a; zgc:63920
Summary: Predicted to enable steroid hydroxylase activity. Predicted to be involved in bile acid biosynthetic process and cholesterol homeostasis. Predicted to act upstream of or within cellular response to glucose stimulus and cholesterol catabolic process. Predicted to be located in endoplasmic reticulum membrane. Predicted to be integral component of membrane. Is expressed in basal plate midbrain region; central nervous system; otic vesicle; and retinal ganglion cell layer. Orthologous to human CYP7A1 (cytochrome P450 family 7 subfamily A member 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 2

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	2	NC_007113.7 (22150134..22152791, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	2	NC_007113.6 (22492072..22494729, complement)

Chromosome 2 - NC_007113.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

a previously unknown role of cyp7a1 as the host gene that links the intestinal tumor, hepatic cholesterol-bile alcohol metabolism and liver inflammation in tumor-bearing zebrafish larvae, is reported.
Title: A novel zebrafish intestinal tumor model reveals a role for cyp7a1-dependent tumor-liver crosstalk in causing adverse effects on the host.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables cholesterol 7-alpha-monooxygenase activity	IEA Inferred from Electronic Annotation more info
enables heme binding	IEA Inferred from Electronic Annotation more info
enables iron ion binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables monooxygenase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	IEA Inferred from Electronic Annotation more info
enables steroid hydroxylase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in bile acid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within bile acid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in bile acid biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to glucose stimulus	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cholesterol catabolic process	IEA Inferred from Electronic Annotation more info
involved_in cholesterol homeostasis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cholesterol homeostasis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cholesterol metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within steroid metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: cytochrome P450 7A1

Names: cytochrome P450, family 7, subfamily A, polypeptide 1a

NP_957467.2

EC 1.14.14.23

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_201173.2 → NP_957467.2 cytochrome P450 7A1

Status: VALIDATED

Source sequence(s)

CR450692

UniProtKB/TrEMBL

A0A8N7V041, F1QU76

Related

ENSDARP00000113850.1, ENSDART00000145188.2

Conserved Domains (1) summary

cl12078
Location:33 → 505

p450; Cytochrome P450