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sh3glb2b SH3-domain GRB2-like endophilin B2b [ Danio rerio (zebrafish) ]

Gene ID: 394094, updated on 27-Mar-2024

Summary

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Official Symbol
sh3glb2bprovided by ZNC
Official Full Name
SH3-domain GRB2-like endophilin B2bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-833
See related
Ensembl:ENSDARG00000035470 AllianceGenome:ZFIN:ZDB-GENE-040426-833
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
sh3glb2; zgc:55887
Summary
Predicted to be involved in membrane organization. Predicted to be located in cytoplasm. Predicted to be active in membrane. Is expressed in central nervous system; eye; immature eye; lens; and solid lens vesicle. Orthologous to human SH3GLB2 (SH3 domain containing GRB2 like, endophilin B2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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Location:
chromosome: 5
Exon count:
14
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (31644448..31689928, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (31044295..31089799, complement)

Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene si:dkey-220k22.3 Neighboring gene uncharacterized LOC100535208 Neighboring gene uncharacterized LOC101883628 Neighboring gene phosphatidylinositol-4-phosphate 5-kinase-like 1 Neighboring gene dolichyl-phosphate mannosyltransferase subunit 2, regulatory

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. RNA-Seq analysis in mutant zebrafish reveals role of U1C protein in alternative splicing regulation. Rösel TD, et al. EMBO J, 2011 May 18. PMID 21468032, Free PMC Article
  2. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
  3. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC55887

Gene Ontology Provided by ZFIN

Process Evidence Code Pubs
involved_in membrane organization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
endophilin-B2; endophilin-B2b
Names
SH3-domain GRB2-like endophilin B2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_201119.1 → NP_957413.1  endophilin-B2b

    See identical proteins and their annotated locations for NP_957413.1

    Status: PROVISIONAL

    Source sequence(s)
    BC047195
    UniProtKB/TrEMBL
    A0A8N1Z3P9, Q802U5
    Related
    ENSDARP00000088944.4, ENSDART00000098172.6
    Conserved Domains (2) summary
    cd11944
    Location:317 → 371
    SH3_Endophilin_B2; Src homology 3 domain of Endophilin-B2
    cl12013
    Location:21 → 249
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007116.7 Reference GRCz11 Primary Assembly

    Range
    31644448..31689928 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021476045.1 → XP_021331720.1  endophilin-B2 isoform X2

    UniProtKB/TrEMBL
    A0A8M9QDN1
    Conserved Domains (2) summary
    cd11944
    Location:361 → 415
    SH3_Endophilin_B2; Src homology 3 domain of Endophilin-B2
    cl12013
    Location:21 → 293
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  2. XM_021476044.1 → XP_021331719.1  endophilin-B2 isoform X1

    UniProtKB/TrEMBL
    A0A8M9Q303
    Conserved Domains (2) summary
    cd11944
    Location:365 → 419
    SH3_Endophilin_B2; Src homology 3 domain of Endophilin-B2
    cl12013
    Location:21 → 297
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  3. XM_021476047.1 → XP_021331722.1  endophilin-B2 isoform X6

    UniProtKB/TrEMBL
    A0A2R8QMQ9, A0A8M9PJT5
    Related
    ENSDARP00000155783.1, ENSDART00000190229.1
    Conserved Domains (2) summary
    cd07617
    Location:21 → 270
    BAR_Endophilin_B2; The Bin/Amphiphysin/Rvs (BAR) domain of Endophilin-B2
    cd11944
    Location:338 → 392
    SH3_Endophilin_B2; Src homology 3 domain of Endophilin-B2

  4. XM_005171809.4 → XP_005171866.1  endophilin-B2 isoform X4

    UniProtKB/TrEMBL
    A0A8M2BJ56, A2CEP2
    Related
    ENSDARP00000114502.1, ENSDART00000147065.3
    Conserved Domains (2) summary
    cd07617
    Location:21 → 278
    BAR_Endophilin_B2; The Bin/Amphiphysin/Rvs (BAR) domain of Endophilin-B2
    cd11944
    Location:346 → 400
    SH3_Endophilin_B2; Src homology 3 domain of Endophilin-B2

  5. XM_021476046.1 → XP_021331721.1  endophilin-B2 isoform X5

    UniProtKB/TrEMBL
    A0A8M9Q8B5
    Conserved Domains (2) summary
    cd11944
    Location:342 → 396
    SH3_Endophilin_B2; Src homology 3 domain of Endophilin-B2
    cl12013
    Location:21 → 274
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  6. XM_021476048.1 → XP_021331723.1  endophilin-B2 isoform X7

    UniProtKB/TrEMBL
    A0A8M9PX86
    Conserved Domains (2) summary
    cd07617
    Location:21 → 261
    BAR_Endophilin_B2; The Bin/Amphiphysin/Rvs (BAR) domain of Endophilin-B2
    cd11944
    Location:329 → 383
    SH3_Endophilin_B2; Src homology 3 domain of Endophilin-B2

  7. XM_005171808.4 → XP_005171865.1  endophilin-B2 isoform X3

    UniProtKB/TrEMBL
    A0A2R8Q0C3, A0A8M2BJ23
    Related
    ENSDARP00000146608.1, ENSDART00000184319.1
    Conserved Domains (2) summary
    cd11944
    Location:350 → 404
    SH3_Endophilin_B2; Src homology 3 domain of Endophilin-B2
    cl12013
    Location:21 → 282
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  8. XM_021476049.1 → XP_021331724.1  endophilin-B2 isoform X8

    UniProtKB/TrEMBL
    A0A8M9Q307
    Conserved Domains (2) summary
    cd11944
    Location:321 → 375
    SH3_Endophilin_B2; Src homology 3 domain of Endophilin-B2
    cl12013
    Location:21 → 253
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394584.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    292507..331080 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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