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sh3gl2a SH3 domain containing GRB2 like 2a, endophilin A1 [ Danio rerio (zebrafish) ]

Gene ID: 394091, updated on 11-Apr-2024

Summary

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Official Symbol
sh3gl2aprovided by ZNC
Official Full Name
SH3 domain containing GRB2 like 2a, endophilin A1provided by ZNC
Primary source
ZFIN:ZDB-GENE-040121-3
See related
Ensembl:ENSDARG00000023600 AllianceGenome:ZFIN:ZDB-GENE-040121-3
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
sh3gl2; zgc:55616
Summary
Predicted to enable lipid binding activity. Predicted to be involved in synaptic vesicle uncoating. Predicted to be located in membrane. Predicted to be active in cytoplasm; glutamatergic synapse; and presynapse. Is expressed in nervous system; neural plate; neural tube; polster; and trigeminal placode. Orthologous to human SH3GL2 (SH3 domain containing GRB2 like 2, endophilin A1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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Location:
chromosome: 1
Exon count:
9
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 1 NC_007112.7 (26740719..26782513, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 1 NC_007112.6 (26047005..26088799, complement)

Chromosome 1 - NC_007112.7Genomic Context describing neighboring genes Neighboring gene si:dkey-25o16.4 Neighboring gene forkhead box E1 Neighboring gene centlein, centrosomal protein Neighboring gene basonuclin zinc finger protein 2 Neighboring gene uncharacterized LOC101882912

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Essential role of SH3-domain GRB2-like 3 for vascular lumen maintenance in zebrafish. Zhao Y, et al. Arterioscler Thromb Vasc Biol, 2013 Jun. PMID 23539215
  2. Systematic identification of rhythmic genes reveals camk1gb as a new element in the circadian clockwork. Tovin A, et al. PLoS Genet, 2012. PMID 23284293, Free PMC Article
  3. Characterization of Intracellular Peptides from Zebrafish (Danio rerio) Brain. Teixeira CMM, et al. Zebrafish, 2019 Jun. PMID 31017557
  4. On the crucial cerebellar wound healing-related pathways and their cross-talks after traumatic brain injury in Danio rerio. Wu CC, et al. PLoS One, 2014. PMID 24926785, Free PMC Article
  5. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC55616

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables lipid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in synaptic vesicle uncoating IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in glutamatergic synapse IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in presynapse IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
SH3 domain containing GRB2 like 2a, endophilin A1
Names
SH3-domain GRB2-like 2
SH3-domain GRB2-like 2a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_201116.1 → NP_957410.1  SH3 domain containing GRB2 like 2a, endophilin A1

    See identical proteins and their annotated locations for NP_957410.1

    Status: PROVISIONAL

    Source sequence(s)
    BC044199
    UniProtKB/TrEMBL
    B2GPL2, Q803T6
    Related
    ENSDARP00000085044.3, ENSDART00000090611.6
    Conserved Domains (2) summary
    cd07613
    Location:25 → 247
    BAR_Endophilin_A1; The Bin/Amphiphysin/Rvs (BAR) domain of Endophilin-A1
    cd11803
    Location:288 → 342
    SH3_Endophilin_A; Src homology 3 domain of Endophilin-A

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007112.7 Reference GRCz11 Primary Assembly

    Range
    26740719..26782513 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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