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hnrnpl heterogeneous nuclear ribonucleoprotein L [ Danio rerio (zebrafish) ]

Gene ID: 394074, updated on 27-Mar-2024

Summary

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Official Symbol
hnrnplprovided by ZNC
Official Full Name
heterogeneous nuclear ribonucleoprotein Lprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-710
See related
Ensembl:ENSDARG00000035324 AllianceGenome:ZFIN:ZDB-GENE-040426-710
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
hnrpl; zgc:55429
Summary
Predicted to enable mRNA binding activity. Predicted to be involved in regulation of RNA splicing. Predicted to act upstream of or within mRNA processing. Predicted to be active in nucleus. Is expressed in central nervous system and neural keel. Human ortholog(s) of this gene implicated in hepatocellular carcinoma; lung cancer; and systemic scleroderma. Orthologous to human HNRNPL (heterogeneous nuclear ribonucleoprotein L). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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Location:
chromosome: 5
Exon count:
14
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (36900135..36911908)
105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (36300004..36311750)

Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 8 member 2a Neighboring gene serine and arginine rich splicing factor 7a Neighboring gene kaptin (actin binding protein) Neighboring gene cone-rod homeobox

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. hnRNP L is essential for myogenic differentiation and modulates myotonic dystrophy pathologies. Alexander MS, et al. Muscle Nerve, 2021 Jun. PMID 33651408, Free PMC Article
  2. On the tubulin polymerization promoting proteins of zebrafish. Orosz F. Biochem Biophys Res Commun, 2015 Feb 13. PMID 25576359
  3. Ribosomal Proteins Rpl22 and Rpl22l1 Control Morphogenesis by Regulating Pre-mRNA Splicing. Zhang Y, et al. Cell Rep, 2017 Jan 10. PMID 28076796, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC55429

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of RNA splicing IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
heterogeneous nuclear ribonucleoprotein L

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_201099.1 → NP_957393.1  heterogeneous nuclear ribonucleoprotein L

    See identical proteins and their annotated locations for NP_957393.1

    Status: PROVISIONAL

    Source sequence(s)
    BC045336
    UniProtKB/TrEMBL
    A0A2R8QMT5, F6PE75, Q7ZW09
    Related
    ENSDARP00000051183.4, ENSDART00000051184.5
    Conserved Domains (6) summary
    cd12704
    Location:446 → 529
    RRM4_hnRNPL; RNA recognition motif 4 in vertebrate heterogeneous nuclear ribonucleoprotein L (hnRNP-L)
    cd12780
    Location:39 → 118
    RRM1_hnRNPL; RNA recognition motif 1 in vertebrate heterogeneous nuclear ribonucleoprotein L (hnRNP-L)
    cd12785
    Location:128 → 227
    RRM2_hnRNPL; RNA recognition motif 2 in vertebrate heterogeneous nuclear ribonucleoprotein L (hnRNP-L)
    pfam02084
    Location:265 → 322
    Bindin; Bindin
    TIGR01649
    Location:39 → 534
    hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family
    cl17169
    Location:330 → 403
    RRM_SF; RNA recognition motif (RRM) superfamily

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007116.7 Reference GRCz11 Primary Assembly

    Range
    36900135..36911908
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021476043.1 → XP_021331718.1  heterogeneous nuclear ribonucleoprotein L isoform X1

    UniProtKB/TrEMBL
    A0A8M9PX80
    Conserved Domains (1) summary
    TIGR01649
    Location:39 → 522
    hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394595.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    141172..156962
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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