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Pbgs Porphobilinogen synthase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 39402, updated on 26-Apr-2024

Summary

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Official Symbol
Pbgsprovided by FlyBase
Official Full Name
Porphobilinogen synthaseprovided by FlyBase
Primary source
FLYBASE:FBgn0036271
Locus tag
Dmel_CG10335
See related
AllianceGenome:FB:FBgn0036271
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG10335; delta-ALA-D; Dmdelta-AlaD; Dmel\CG10335; DmPBGS
Summary
Enables porphobilinogen synthase activity. Predicted to be involved in heme biosynthetic process. Predicted to be active in cytosol. Is expressed in several structures, including early extended germ band embryo; embryonic/larval corpus allatum; embryonic/larval oenocyte; foregut primordium; and presumptive embryonic/larval system. Human ortholog(s) of this gene implicated in porphyria cutanea tarda and sickle cell anemia. Orthologous to human ALAD (aminolevulinate dehydratase). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
69A4-69A4; 3-38 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (12269452..12271345, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (12262552..12264445, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene tRNA splicing endonuclease subunit 54 Neighboring gene approximated Neighboring gene long non-coding RNA:CR43991 Neighboring gene uncharacterized protein Neighboring gene Spermine synthase Neighboring gene Inositol polyphosphate 5-phosphatase E

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Se(…)S/N interactions as a possible mechanism of δ-aminolevulinic acid dehydratase enzyme inhibition by organoselenium compounds: A computational study. Nogara PA, et al. Comput Toxicol, 2020 Aug. PMID 32572387, Free PMC Article
  2. A structural basis for half-of-the-sites metal binding revealed in Drosophila melanogaster porphobilinogen synthase. Kundrat L, et al. J Biol Chem, 2003 Aug 15. PMID 12794073
  3. Diphenyl diselenide [(PhSe)2] inhibits Drosophila melanogaster delta-aminolevulinate dehydratase (delta-ALA-D) gene transcription and enzyme activity. Golombieski RM, et al. Comp Biochem Physiol C Toxicol Pharmacol, 2008 Mar. PMID 17936691
  4. An in vivo genetic screen in Drosophila identifies the orthologue of human cancer/testis gene SPO11 among a network of targets to inhibit lethal(3)malignant brain tumour growth. Rossi F, et al. Open Biol, 2017 Aug. PMID 28855394, Free PMC Article
  5. Identification and characterization of a heme exporter from the MRP family in Drosophila melanogaster. Wang Z, et al. BMC Biol, 2022 Jun 2. PMID 35655259, Free PMC Article

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables porphobilinogen synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables porphobilinogen synthase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables porphobilinogen synthase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in heme biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tetrapyrrole biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
porphobilinogen synthase
Names
CG10335-PA
CG10335-PB
Pbgs-PA
Pbgs-PB
delta-aminolevulinate dehydratase
NP_001261752.1
NP_648564.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    12269452..12271345 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001274823.1 → NP_001261752.1  porphobilinogen synthase, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261752.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VTV9
    Conserved Domains (1) summary
    cd04824
    Location:6 → 323
    eu_ALAD_PBGS_cysteine_rich; Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the ...

  2. NM_140307.4 → NP_648564.1  porphobilinogen synthase, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_648564.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VTV9
    Related
    FBpp0075743
    Conserved Domains (1) summary
    cd04824
    Location:6 → 323
    eu_ALAD_PBGS_cysteine_rich; Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VTV9 Q9VTV9

Gene LinkOut

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