pdk2b pyruvate dehydrogenase kinase 2b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: pdk2bprovided by ZNC
Official Full Name: pyruvate dehydrogenase kinase 2bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-939
See related: Ensembl:ENSDARG00000059054 AllianceGenome:ZFIN:ZDB-GENE-040426-939
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: Pdk; pdk2; zgc:56209
Summary: Predicted to enable pyruvate dehydrogenase (acetyl-transferring) kinase activity. Predicted to be involved in protein phosphorylation and regulation of glucose metabolic process. Predicted to act upstream of or within phosphorylation. Predicted to be located in mitochondrial matrix. Predicted to be active in mitochondrion. Orthologous to human PDK2 (pyruvate dehydrogenase kinase 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 19

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	19	NC_007130.7 (5674893..5687749)
105	previous assembly	GRCz10 (GCF_000002035.5)	19	NC_007130.6 (5756660..5769491)

Chromosome 19 - NC_007130.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables pyruvate dehydrogenase (acetyl-transferring) kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in protein phosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of glucose metabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in mitochondrial matrix	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: pyruvate dehydrogenase kinase 2b; pyruvate dehydrogenase kinase isozyme 2, mitochondrial

Names: pyruvate dehydrogenase kinase, isoenzyme 2; pyruvate dehydrogenase kinase, isoenzyme 2b; pyruvate dehydrogenase kinase, isozyme 2b

NP_957290.1

EC 2.7.11.2

XP_021323697.1

EC 2.7.11.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_200996.1 → NP_957290.1 pyruvate dehydrogenase kinase 2b

See identical proteins and their annotated locations for NP_957290.1

Status: PROVISIONAL

Source sequence(s)

BC045993

UniProtKB/TrEMBL

Q7ZV57

Related

ENSDARP00000042188.6, ENSDART00000042189.7

Conserved Domains (3) summary

smart00387
Location:242 → 362

HATPase_c; Histidine kinase-like ATPases

COG0642
Location:196 → 370

BaeS; Signal transduction histidine kinase [Signal transduction mechanisms]

pfam10436
Location:30 → 192

BCDHK_Adom3; Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007130.7 Reference GRCz11 Primary Assembly

Range

5674893..5687749

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021468022.1 → XP_021323697.1 pyruvate dehydrogenase kinase isozyme 2, mitochondrial isoform X1

UniProtKB/TrEMBL

A0A8M9P1R7

Conserved Domains (2) summary

smart00387
Location:242 → 362

HATPase_c; Histidine kinase-like ATPases

pfam10436
Location:30 → 192

BCDHK_Adom3; Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase