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ndufb8 NADH:ubiquinone oxidoreductase subunit B8 [ Danio rerio (zebrafish) ]

Gene ID: 393829, updated on 13-Apr-2024

Summary

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Official Symbol
ndufb8provided by ZNC
Official Full Name
NADH:ubiquinone oxidoreductase subunit B8provided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-1858
See related
Ensembl:ENSDARG00000010113 AllianceGenome:ZFIN:ZDB-GENE-040426-1858
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
nduf8; zgc:77718
Summary
Predicted to enable NADH dehydrogenase (ubiquinone) activity. Predicted to be involved in mitochondrial electron transport, NADH to ubiquinone. Predicted to be located in mitochondrial inner membrane and respirasome. Predicted to be integral component of membrane. Predicted to be part of mitochondrial respiratory chain complex I. Human ortholog(s) of this gene implicated in nuclear type mitochondrial complex I deficiency 32. Orthologous to human NDUFB8 (NADH:ubiquinone oxidoreductase subunit B8). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 12
Exon count:
5
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 12 NC_007123.7 (48469755..48477013, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 12 NC_007123.6 (48486433..48493691, complement)

Chromosome 12 - NC_007123.7Genomic Context describing neighboring genes Neighboring gene stearoyl-CoA desaturase (delta-9-desaturase) Neighboring gene SEC31 homolog B, COPII coat complex component Neighboring gene Rho GTPase activating protein 44b Neighboring gene uncharacterized LOC108191761 Neighboring gene testis expressed 47

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Ccn6 Is Required for Mitochondrial Integrity and Skeletal Muscle Function in Zebrafish. Sengupta A, et al. Front Cell Dev Biol, 2021. PMID 33644064, Free PMC Article
  2. BDE-47 induced apoptosis in zebrafish embryos through mitochondrial ROS-mediated JNK signaling. Zhuang J, et al. Chemosphere, 2020 Nov. PMID 32947675
  3. Opa1 is required for proper mitochondrial metabolism in early development. Rahn JJ, et al. PLoS One, 2013. PMID 23516612, Free PMC Article
  4. A metabolic interplay coordinated by HLX regulates myeloid differentiation and AML through partly overlapping pathways. Piragyte I, et al. Nat Commun, 2018 Aug 6. PMID 30082823, Free PMC Article
  5. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC77718

Gene Ontology Provided by ZFIN

Process Evidence Code Pubs
acts_upstream_of_or_within mitochondrial electron transport, NADH to ubiquinone IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrial electron transport, NADH to ubiquinone IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrial respiratory chain complex I assembly IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
part_of mitochondrial respiratory chain complex I IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of mitochondrial respiratory chain complex I IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in respirasome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial
Names
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8
NP_957149.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_200855.1 → NP_957149.1  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial

    See identical proteins and their annotated locations for NP_957149.1

    Status: PROVISIONAL

    Source sequence(s)
    BC062842
    UniProtKB/TrEMBL
    A0A8M1PBV6, Q6P5L5
    Related
    ENSDARP00000095947.3, ENSDART00000105176.4
    Conserved Domains (1) summary
    pfam05821
    Location:22 → 188
    NDUF_B8; NADH-ubiquinone oxidoreductase ASHI subunit (CI-ASHI or NDUFB8)

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007123.7 Reference GRCz11 Primary Assembly

    Range
    48469755..48477013 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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