qki2 QKI, KH domain containing, RNA binding 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: qki2provided by ZNC
Official Full Name: QKI, KH domain containing, RNA binding 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-1462
See related: Ensembl:ENSDARG00000010018 AllianceGenome:ZFIN:ZDB-GENE-040426-1462
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: qkr; qkib; qkic; zgc:65890; zgc:77340
Summary: Predicted to enable mRNA binding activity. Acts upstream of or within skeletal myofibril assembly. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Is expressed in several structures, including cardiovascular system; central nervous system; lateral line system; myotome; and segmental plate. Orthologous to human QKI (QKI, KH domain containing RNA binding). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 12

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	12	NC_007123.7 (34953072..35023266)
105	previous assembly	GRCz10 (GCF_000002035.5)	12	NC_007123.6 (34852025..34918582)

Chromosome 12 - NC_007123.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

qki2 is an ortholog, emerging at the root of the vertebrate and teleost lineage, respectively. qki2 was expressed in the progenitor domains of the central nervous system.
Title: Characterization and Expression of the Zebrafish qki Paralogs.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables SH3 domain binding	IEA Inferred from Electronic Annotation more info
enables mRNA 3'-UTR binding	IDA Inferred from Direct Assay more info	PubMed
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within RNA splicing	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mRNA processing	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mRNA transport	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of macrophage differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of astrocyte differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of mRNA splicing, via spliceosome	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of translation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within skeletal myofibril assembly	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: protein quaking-B

Names: quaking; quaking c; quaking-related protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_200842.2 → NP_957136.2 protein quaking-B

See identical proteins and their annotated locations for NP_957136.2

Status: PROVISIONAL

Source sequence(s)

BC065344

UniProtKB/Swiss-Prot

Q6P104, Q6P7D9

Related

ENSDARP00000020217.8, ENSDART00000027034.10

Conserved Domains (3) summary

PRK04654
Location:139 → 299

PRK04654; sec-independent translocase; Provisional

cd02395
Location:83 → 205

SF1_like-KH; Splicing factor 1 (SF1) K homology RNA-binding domain (KH). Splicing factor 1 (SF1) specifically recognizes the intron branch point sequence (BPS) UACUAAC in the pre-mRNA transcripts during spliceosome assembly. We show that the KH-QUA2 region of SF1 ...

pfam16544
Location:10 → 68

STAR_dimer; Homodimerization region of STAR domain protein

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007123.7 Reference GRCz11 Primary Assembly

Range

34953072..35023266

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021480039.1 → XP_021335714.1 protein quaking-B isoform X2

UniProtKB/TrEMBL

A0A8M9QE52

Conserved Domains (4) summary

cd02395
Location:83 → 205

SF1_like-KH; Splicing factor 1 (SF1) K homology RNA-binding domain (KH). Splicing factor 1 (SF1) specifically recognizes the intron branch point sequence (BPS) UACUAAC in the pre-mRNA transcripts during spliceosome assembly. We show that the KH-QUA2 region of SF1 ...

pfam16551
Location:313 → 340

Quaking_NLS; Putative nuclear localization signal of quaking

pfam16544
Location:10 → 68

STAR_dimer; Homodimerisation region of STAR domain protein

cl26677
Location:139 → 298

PRK00708; sec-independent translocase; Provisional
XM_021480038.1 → XP_021335713.1 protein quaking-B isoform X1

UniProtKB/TrEMBL

A0A8M9Q889

Conserved Domains (4) summary

cd02395
Location:83 → 205

SF1_like-KH; Splicing factor 1 (SF1) K homology RNA-binding domain (KH). Splicing factor 1 (SF1) specifically recognizes the intron branch point sequence (BPS) UACUAAC in the pre-mRNA transcripts during spliceosome assembly. We show that the KH-QUA2 region of SF1 ...

pfam16551
Location:314 → 341

Quaking_NLS; Putative nuclear localization signal of quaking

pfam16544
Location:10 → 68

STAR_dimer; Homodimerisation region of STAR domain protein

cl26677
Location:139 → 299

PRK00708; sec-independent translocase; Provisional
XM_005156355.4 → XP_005156412.1 protein quaking-B isoform X3

See identical proteins and their annotated locations for XP_005156412.1

UniProtKB/Swiss-Prot

Q6P104

Related

ENSDARP00000110005.1, ENSDART00000123988.4

Conserved Domains (3) summary

PRK04654
Location:139 → 298

PRK04654; sec-independent translocase; Provisional

cd02395
Location:83 → 205

SF1_like-KH; Splicing factor 1 (SF1) K homology RNA-binding domain (KH). Splicing factor 1 (SF1) specifically recognizes the intron branch point sequence (BPS) UACUAAC in the pre-mRNA transcripts during spliceosome assembly. We show that the KH-QUA2 region of SF1 ...

pfam16544
Location:10 → 68

STAR_dimer; Homodimerization region of STAR domain protein